Effects of anaesthesia on regional coronary control mechanisms

D. B F Cottee, A. W. Quail, W. L. Porges, Peter G Moore, S. W. White

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


1. The regional coronary circulation is under the control of local metabolic and myogenic factors, but is also influenced by autonomic systems, including sympathetic and parasympathetic nerves. 2. General anaesthetic agents influence not only local control through changes in metabolic demand, but also neural control through suppression of autonomic influence. 3. Anaesthetic agents have differing effects on reflex control systems, which are dependent on coronary territory and ventricular rate. 4. Effects of anaesthesia should be taken into account when interpreting results in anaesthetized models of coronary control.

Original languageEnglish (US)
Pages (from-to)1034-1038
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Issue number12
StatePublished - 2000


  • Barbiturates
  • Baroreflex
  • Chemoreflex
  • Conscious dog
  • Coronary
  • Enflurane
  • Halothane
  • Isoflurane

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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