Effects of anaesthesia on regional coronary control mechanisms

D. B F Cottee, A. W. Quail, W. L. Porges, Peter G Moore, S. W. White

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

1. The regional coronary circulation is under the control of local metabolic and myogenic factors, but is also influenced by autonomic systems, including sympathetic and parasympathetic nerves. 2. General anaesthetic agents influence not only local control through changes in metabolic demand, but also neural control through suppression of autonomic influence. 3. Anaesthetic agents have differing effects on reflex control systems, which are dependent on coronary territory and ventricular rate. 4. Effects of anaesthesia should be taken into account when interpreting results in anaesthetized models of coronary control.

Original languageEnglish (US)
Pages (from-to)1034-1038
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume27
Issue number12
DOIs
StatePublished - 2000

Fingerprint

Conduction Anesthesia
Anesthetics
General Anesthetics
Coronary Circulation
Reflex
Anesthesia

Keywords

  • Barbiturates
  • Baroreflex
  • Chemoreflex
  • Conscious dog
  • Coronary
  • Enflurane
  • Halothane
  • Isoflurane

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Effects of anaesthesia on regional coronary control mechanisms. / Cottee, D. B F; Quail, A. W.; Porges, W. L.; Moore, Peter G; White, S. W.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 27, No. 12, 2000, p. 1034-1038.

Research output: Contribution to journalArticle

Cottee, D. B F ; Quail, A. W. ; Porges, W. L. ; Moore, Peter G ; White, S. W. / Effects of anaesthesia on regional coronary control mechanisms. In: Clinical and Experimental Pharmacology and Physiology. 2000 ; Vol. 27, No. 12. pp. 1034-1038.
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