Effects of Air Pollutants on Development of Allergic Immune Responses in the Respiratory Tract

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10 Scopus citations

Abstract

The increased incidence of allergic asthma in the human population worldwide has stimulated many explanatory theories. A concomitant decrease in air quality leads to epidemiological and laboratory-based studies to demonstrate a link between air pollutants and asthma. Specifically, ozone, environmental tobacco smoke, and diesel exhaust are associated with enhancement of respiratory allergy to inhaled allergens. This review summarizes the state of the knowledge, both human epidemiology and laboratory animal experiments, linking air pollution to allergy. Critical issues involve development of the lung and the fetal immune response, and the potential for substances like ozone and ETS in the air to modulate early immune responses with lifelong consequences.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalClinical and Developmental Immunology
Volume10
Issue number2-4
DOIs
StatePublished - Jun 2003

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Keywords

  • Air pollution
  • Asthma
  • Developmental immunology
  • IgE

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Developmental Biology

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