Effects of acute clomipramine administration on Syrian hamster circadian rhythms

Paola C. Yannielli; Martín Cadeiras; Daniel P. Cardinali; Diego Andrés Golombek

doi:10.1076/brhm.29.5.530.4822

Effects of acute clomipramine administration on Syrian hamster circadian rhythms

Paola C. Yannielli, Martín Cadeiras, Daniel P. Cardinali, Diego Andrés Golombek

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Drugs linked to the serotonergic system, like antidepressants, are able to modify the circadian system. The present experiments were designed to test whether clomipramine, a 5-HT reuptake inhibitor, was able to modify: a) the phase of free running activity rhythms; b) the light-induced phase shifts in Syrian hamsters. Clomipramine had a phase-dependent effect on the free running activity rhythm, with phase advances at CT 0-8 being significantly higher than at CT 8-16. Pretreatment with clomipramine inhibited phase advances in response to light pulses when applied at CT 19 while delays remained unaffected. The results suggest that acute clomipramine treatment can affect the expression of the circadian rhythmicity in Syrian hamsters.

Original language	English (US)
Pages (from-to)	530-537
Number of pages	8
Journal	Biological Rhythm Research
Volume	29
Issue number	5
DOIs	https://doi.org/10.1076/brhm.29.5.530.4822
State	Published - Jan 1 1998
Externally published	Yes

Keywords

5-HT reuptake inhibitors
Circadian rhythms
Clomipramine
Hamsters

ASJC Scopus subject areas

Physiology
Ecology, Evolution, Behavior and Systematics
Physiology (medical)

Access to Document

10.1076/brhm.29.5.530.4822

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title = "Effects of acute clomipramine administration on Syrian hamster circadian rhythms",

abstract = "Drugs linked to the serotonergic system, like antidepressants, are able to modify the circadian system. The present experiments were designed to test whether clomipramine, a 5-HT reuptake inhibitor, was able to modify: a) the phase of free running activity rhythms; b) the light-induced phase shifts in Syrian hamsters. Clomipramine had a phase-dependent effect on the free running activity rhythm, with phase advances at CT 0-8 being significantly higher than at CT 8-16. Pretreatment with clomipramine inhibited phase advances in response to light pulses when applied at CT 19 while delays remained unaffected. The results suggest that acute clomipramine treatment can affect the expression of the circadian rhythmicity in Syrian hamsters.",

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