Abstract
Drugs linked to the serotonergic system, like antidepressants, are able to modify the circadian system. The present experiments were designed to test whether clomipramine, a 5-HT reuptake inhibitor, was able to modify: a) the phase of free running activity rhythms; b) the light-induced phase shifts in Syrian hamsters. Clomipramine had a phase-dependent effect on the free running activity rhythm, with phase advances at CT 0-8 being significantly higher than at CT 8-16. Pretreatment with clomipramine inhibited phase advances in response to light pulses when applied at CT 19 while delays remained unaffected. The results suggest that acute clomipramine treatment can affect the expression of the circadian rhythmicity in Syrian hamsters.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 530-537 |
| Number of pages | 8 |
| Journal | Biological Rhythm Research |
| Volume | 29 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 1998 |
| Externally published | Yes |
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Keywords
- 5-HT reuptake inhibitors
- Circadian rhythms
- Clomipramine
- Hamsters
ASJC Scopus subject areas
- Physiology
- Ecology, Evolution, Behavior and Systematics
- Physiology (medical)
Cite this
Effects of acute clomipramine administration on Syrian hamster circadian rhythms. / Yannielli, Paola C.; Cadeiras, Martín; Cardinali, Daniel P.; Golombek, Diego Andrés.
In: Biological Rhythm Research, Vol. 29, No. 5, 01.01.1998, p. 530-537.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of acute clomipramine administration on Syrian hamster circadian rhythms
AU - Yannielli, Paola C.
AU - Cadeiras, Martín
AU - Cardinali, Daniel P.
AU - Golombek, Diego Andrés
PY - 1998/1/1
Y1 - 1998/1/1
N2 - Drugs linked to the serotonergic system, like antidepressants, are able to modify the circadian system. The present experiments were designed to test whether clomipramine, a 5-HT reuptake inhibitor, was able to modify: a) the phase of free running activity rhythms; b) the light-induced phase shifts in Syrian hamsters. Clomipramine had a phase-dependent effect on the free running activity rhythm, with phase advances at CT 0-8 being significantly higher than at CT 8-16. Pretreatment with clomipramine inhibited phase advances in response to light pulses when applied at CT 19 while delays remained unaffected. The results suggest that acute clomipramine treatment can affect the expression of the circadian rhythmicity in Syrian hamsters.
AB - Drugs linked to the serotonergic system, like antidepressants, are able to modify the circadian system. The present experiments were designed to test whether clomipramine, a 5-HT reuptake inhibitor, was able to modify: a) the phase of free running activity rhythms; b) the light-induced phase shifts in Syrian hamsters. Clomipramine had a phase-dependent effect on the free running activity rhythm, with phase advances at CT 0-8 being significantly higher than at CT 8-16. Pretreatment with clomipramine inhibited phase advances in response to light pulses when applied at CT 19 while delays remained unaffected. The results suggest that acute clomipramine treatment can affect the expression of the circadian rhythmicity in Syrian hamsters.
KW - 5-HT reuptake inhibitors
KW - Circadian rhythms
KW - Clomipramine
KW - Hamsters
UR - http://www.scopus.com/inward/record.url?scp=0032407635&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032407635&partnerID=8YFLogxK
U2 - 10.1076/brhm.29.5.530.4822
DO - 10.1076/brhm.29.5.530.4822
M3 - Article
AN - SCOPUS:0032407635
VL - 29
SP - 530
EP - 537
JO - Biological Rhythm Research
JF - Biological Rhythm Research
SN - 0929-1016
IS - 5
ER -