Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination

Karen A. van Haaften, Lauren R. Eichstadt Forsythe, Elizabeth A. Stelow, Melissa Bain

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


OBJECTIVE To determine the effects of oral gabapentin administration prior to veteri­nary examination on signs of stress in cats. DESIGN Randomized, blinded, crossover clinical trial. ANIMALS 20 healthy pet cats with a history of fractious behavior or signs of stress during veterinary examination. PROCEDURES Cats were scheduled for 2 veterinary visits 1 week apart and randomly as­signed to receive a capsule containing 100 mg of gabapentin (13.0 to 29.4 mg/kg [5.9 to 13.4 mg/lb]) or placebo (lactose powder) prior to the first visit and the opposite treatment prior to the second visit. Owners were instructed to administer the assigned capsule orally 90 minutes prior to placing the cat into a carrier and transporting it to the veterinary hospi­tal. Standardized physical examinations and blood pressure readings were performed. Owners assigned a cat stress score during transportation and examination, and the veterinarian assigned a compliance score at the visit. Scores were compared between treatments, controlling for various factors. RESULTS Owner-assessed cat stress scores during transportation and veterinary ex­amination and veterinarian-assessed compliance scores were significantly lower when cats received gabapentin than when they received the placebo. Sedation was a common effect of gabapentin administration, and ataxia, hypersalivation, and vomiting were also reported. All effects resolved with­in 8 hours after gabapentin administration. CONCLUSIONS AND CLINICAL RELEVANCE Owners’ perception of stress in their cats is a primary reason for failing to seek veterinary care. Results of this study suggested that gabapentin is a safe and effective treatment for cats to help reduce stress and aggression and increase compliance for transportation and veterinary examination.

Original languageEnglish (US)
Pages (from-to)1175-1181
Number of pages7
JournalJournal of the American Veterinary Medical Association
Issue number10
StatePublished - Nov 15 2017

ASJC Scopus subject areas

  • veterinary(all)


Dive into the research topics of 'Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination'. Together they form a unique fingerprint.

Cite this