Abstract
Objective To determine whether adding mindfulness-based eating and stress management practices to a diet-exercise program improves weight loss and metabolic syndrome components. Methods In this study 194 adults with obesity were randomized to a 5.5-month program with or without mindfulness training and identical diet-exercise guidelines. Intention-to-treat analyses with multiple imputation were used for missing data. The primary outcome was 18-month weight change. Results Estimated effects comparing the mindfulness to control arm favored the mindfulness arm in (a) weight loss at 12 months, -1.9 kg (95% CI: -4.5, 0.8; P = 0.17), and 18 months, -1.7 kg (95% CI: -4.7, 1.2; P = 0.24), though not statistically significant; (b) changes in fasting glucose at 12 months, -3.1 mg/dl (95% CI: -6.3, 0.1; P = 0.06), and 18 months, -4.1 mg/dl (95% CI: -7.3, -0.9; P = 0.01); and (c) changes in triglyceride/HDL ratio at 12 months, -0.57 (95% CI: -0.95, -0.18; P = 0.004), and 18 months, -0.36 (95% CI: -0.74, 0.03; P = 0.07). Estimates for other metabolic risk factors were not statistically significant, including waist circumference, blood pressure, and C-reactive protein. Conclusions Mindfulness enhancements to a diet-exercise program did not show substantial weight loss benefit but may promote long-term improvement in some aspects of metabolic health in obesity that requires further study.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 794-804 |
| Number of pages | 11 |
| Journal | Obesity |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2016 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
Cite this
Effects of a mindfulness-based weight loss intervention in adults with obesity : A randomized clinical trial. / Daubenmier, Jennifer; Moran, Patricia J.; Kristeller, Jean; Acree, Michael; Bacchetti, Peter; Kemeny, Margaret E.; Dallman, Mary; Lustig, Robert H.; Grunfeld, Carl; Nixon, Douglas F.; Milush, Jeffrey M.; Goldman, Veronica; Laraia, Barbara; Laugero, Kevin D.; Woodhouse, Leslie; Epel, Elissa S.; Hecht, Frederick M.
In: Obesity, Vol. 24, No. 4, 01.04.2016, p. 794-804.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of a mindfulness-based weight loss intervention in adults with obesity
T2 - A randomized clinical trial
AU - Daubenmier, Jennifer
AU - Moran, Patricia J.
AU - Kristeller, Jean
AU - Acree, Michael
AU - Bacchetti, Peter
AU - Kemeny, Margaret E.
AU - Dallman, Mary
AU - Lustig, Robert H.
AU - Grunfeld, Carl
AU - Nixon, Douglas F.
AU - Milush, Jeffrey M.
AU - Goldman, Veronica
AU - Laraia, Barbara
AU - Laugero, Kevin D.
AU - Woodhouse, Leslie
AU - Epel, Elissa S.
AU - Hecht, Frederick M.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Objective To determine whether adding mindfulness-based eating and stress management practices to a diet-exercise program improves weight loss and metabolic syndrome components. Methods In this study 194 adults with obesity were randomized to a 5.5-month program with or without mindfulness training and identical diet-exercise guidelines. Intention-to-treat analyses with multiple imputation were used for missing data. The primary outcome was 18-month weight change. Results Estimated effects comparing the mindfulness to control arm favored the mindfulness arm in (a) weight loss at 12 months, -1.9 kg (95% CI: -4.5, 0.8; P = 0.17), and 18 months, -1.7 kg (95% CI: -4.7, 1.2; P = 0.24), though not statistically significant; (b) changes in fasting glucose at 12 months, -3.1 mg/dl (95% CI: -6.3, 0.1; P = 0.06), and 18 months, -4.1 mg/dl (95% CI: -7.3, -0.9; P = 0.01); and (c) changes in triglyceride/HDL ratio at 12 months, -0.57 (95% CI: -0.95, -0.18; P = 0.004), and 18 months, -0.36 (95% CI: -0.74, 0.03; P = 0.07). Estimates for other metabolic risk factors were not statistically significant, including waist circumference, blood pressure, and C-reactive protein. Conclusions Mindfulness enhancements to a diet-exercise program did not show substantial weight loss benefit but may promote long-term improvement in some aspects of metabolic health in obesity that requires further study.
AB - Objective To determine whether adding mindfulness-based eating and stress management practices to a diet-exercise program improves weight loss and metabolic syndrome components. Methods In this study 194 adults with obesity were randomized to a 5.5-month program with or without mindfulness training and identical diet-exercise guidelines. Intention-to-treat analyses with multiple imputation were used for missing data. The primary outcome was 18-month weight change. Results Estimated effects comparing the mindfulness to control arm favored the mindfulness arm in (a) weight loss at 12 months, -1.9 kg (95% CI: -4.5, 0.8; P = 0.17), and 18 months, -1.7 kg (95% CI: -4.7, 1.2; P = 0.24), though not statistically significant; (b) changes in fasting glucose at 12 months, -3.1 mg/dl (95% CI: -6.3, 0.1; P = 0.06), and 18 months, -4.1 mg/dl (95% CI: -7.3, -0.9; P = 0.01); and (c) changes in triglyceride/HDL ratio at 12 months, -0.57 (95% CI: -0.95, -0.18; P = 0.004), and 18 months, -0.36 (95% CI: -0.74, 0.03; P = 0.07). Estimates for other metabolic risk factors were not statistically significant, including waist circumference, blood pressure, and C-reactive protein. Conclusions Mindfulness enhancements to a diet-exercise program did not show substantial weight loss benefit but may promote long-term improvement in some aspects of metabolic health in obesity that requires further study.
UR - http://www.scopus.com/inward/record.url?scp=84960330068&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960330068&partnerID=8YFLogxK
U2 - 10.1002/oby.21396
DO - 10.1002/oby.21396
M3 - Article
AN - SCOPUS:84960330068
VL - 24
SP - 794
EP - 804
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 4
ER -