Effects of a behavioral intervention to reduce risk of transmission among people living with HIV: The Healthy Living Project randomized controlled study

Stephen F. Morin, Margaret A. Chesney, Anke A. Ehrhardt, Jeffrey A. Kelly, Willo Pequegnat, Mary Jane Rotheram-Borus, Abdelmonem A. Afifi, Eric G. Benotsch, Michael J. Brondino, Sheryl L Catz, Edwin D. Charlebois, William G. Cumberland, Don C. DesJarlais, Naihua Duan, Theresa M. Exner, Rise B. Goldstein, Cheryl Gore-Felton, A. Elizabeth Hirky, Mallory O. Johnson, Robert M. KertznerSheri B. Kirshenbaum, Lauren E. Kittel, Robert Klitzman, Martha Lee, Bruce Levin, Marguerita Lightfoot, Steven D. Pinkerton, Robert H. Remien, Fen Rhodes, Juwon Song, Wayne T. Steward, Susan Tross, Lance S. Weinhardt, Robert Weiss, Hannah Wolfe, Rachel Wolfe, F. Lennie Wong, Philip Batterham, W. Scott Comulada, Tyson Rogers, Yu Zhao, Jackie Correale, Kristin Hackl, Daniel Hong, Karen Huchting, Joanne D. Mickalian, Margaret Peterson, Christopher M. Gordon, Dianne Rausch, Ellen Stover

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

CONTEXT: The US Centers for Disease Control and Prevention (CDC) strongly recommend comprehensive risk counceling and services for people living with HIV (PLH); yet, there are no evidence-based counseling protocols. OBJECTIVE: To examine the effect of a 15-session, individually delivered, cognitive behavioral intervention on a diverse sample of PLH at risk of transmitting to others. DESIGN: This was a multisite, 2-group, randomized, controlled trial. PARTICIPANTS: Nine hundred thirty-six HIV-infected participants considered to be at risk of transmitting HIV of 3818 persons screened were randomized into the trial. Participants were recruited in Los Angeles, Milwaukee, New York, and San Francisco. INTERVENTION: Fifteen 90-minute individually delivered intervention sessions were divided into 3 modules: stress, coping, and adjustment; safer behaviors; and health behaviors. The control group received no intervention until the trial was completed. Both groups completed follow-up assessments at 5, 10, 15, 20, and 25 months after randomization. MAIN OUTCOME MEASURE: Transmission risk, as measured by the number of unprotected sexual risk acts with persons of HIV-negative or unknown status, was the main outcome measure. RESULTS: Overall, a significance difference in mean transmission risk acts was shown between the intervention and control arms over 5 to 25 months (χ = 16.0, degrees of freedom = 5; P = 0.007). The greatest reduction occurred at the 20-month follow-up, with a 36% reduction in the intervention group compared with the control group. CONCLUSION: Cognitive behavioral intervention programs can effectively reduce the potential of HIV transmission to others among PLH who report significant transmission risk behavior.

Original languageEnglish (US)
Pages (from-to)213-221
Number of pages9
JournalJournal of Acquired Immune Deficiency Syndromes
Volume44
Issue number2
DOIs
StatePublished - Feb 2007
Externally publishedYes

Fingerprint

HIV
Social Adjustment
Control Groups
San Francisco
Los Angeles
Health Behavior
Centers for Disease Control and Prevention (U.S.)
Random Allocation
Risk-Taking
Counseling
Randomized Controlled Trials
Outcome Assessment (Health Care)

Keywords

  • Behavioral trial
  • Prevention case management
  • Prevention with positives

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Effects of a behavioral intervention to reduce risk of transmission among people living with HIV : The Healthy Living Project randomized controlled study. / Morin, Stephen F.; Chesney, Margaret A.; Ehrhardt, Anke A.; Kelly, Jeffrey A.; Pequegnat, Willo; Rotheram-Borus, Mary Jane; Afifi, Abdelmonem A.; Benotsch, Eric G.; Brondino, Michael J.; Catz, Sheryl L; Charlebois, Edwin D.; Cumberland, William G.; DesJarlais, Don C.; Duan, Naihua; Exner, Theresa M.; Goldstein, Rise B.; Gore-Felton, Cheryl; Hirky, A. Elizabeth; Johnson, Mallory O.; Kertzner, Robert M.; Kirshenbaum, Sheri B.; Kittel, Lauren E.; Klitzman, Robert; Lee, Martha; Levin, Bruce; Lightfoot, Marguerita; Pinkerton, Steven D.; Remien, Robert H.; Rhodes, Fen; Song, Juwon; Steward, Wayne T.; Tross, Susan; Weinhardt, Lance S.; Weiss, Robert; Wolfe, Hannah; Wolfe, Rachel; Wong, F. Lennie; Batterham, Philip; Comulada, W. Scott; Rogers, Tyson; Zhao, Yu; Correale, Jackie; Hackl, Kristin; Hong, Daniel; Huchting, Karen; Mickalian, Joanne D.; Peterson, Margaret; Gordon, Christopher M.; Rausch, Dianne; Stover, Ellen.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 44, No. 2, 02.2007, p. 213-221.

Research output: Contribution to journalArticle

Morin, SF, Chesney, MA, Ehrhardt, AA, Kelly, JA, Pequegnat, W, Rotheram-Borus, MJ, Afifi, AA, Benotsch, EG, Brondino, MJ, Catz, SL, Charlebois, ED, Cumberland, WG, DesJarlais, DC, Duan, N, Exner, TM, Goldstein, RB, Gore-Felton, C, Hirky, AE, Johnson, MO, Kertzner, RM, Kirshenbaum, SB, Kittel, LE, Klitzman, R, Lee, M, Levin, B, Lightfoot, M, Pinkerton, SD, Remien, RH, Rhodes, F, Song, J, Steward, WT, Tross, S, Weinhardt, LS, Weiss, R, Wolfe, H, Wolfe, R, Wong, FL, Batterham, P, Comulada, WS, Rogers, T, Zhao, Y, Correale, J, Hackl, K, Hong, D, Huchting, K, Mickalian, JD, Peterson, M, Gordon, CM, Rausch, D & Stover, E 2007, 'Effects of a behavioral intervention to reduce risk of transmission among people living with HIV: The Healthy Living Project randomized controlled study', Journal of Acquired Immune Deficiency Syndromes, vol. 44, no. 2, pp. 213-221. https://doi.org/10.1097/QAI.0b013e31802c0cae
Morin, Stephen F. ; Chesney, Margaret A. ; Ehrhardt, Anke A. ; Kelly, Jeffrey A. ; Pequegnat, Willo ; Rotheram-Borus, Mary Jane ; Afifi, Abdelmonem A. ; Benotsch, Eric G. ; Brondino, Michael J. ; Catz, Sheryl L ; Charlebois, Edwin D. ; Cumberland, William G. ; DesJarlais, Don C. ; Duan, Naihua ; Exner, Theresa M. ; Goldstein, Rise B. ; Gore-Felton, Cheryl ; Hirky, A. Elizabeth ; Johnson, Mallory O. ; Kertzner, Robert M. ; Kirshenbaum, Sheri B. ; Kittel, Lauren E. ; Klitzman, Robert ; Lee, Martha ; Levin, Bruce ; Lightfoot, Marguerita ; Pinkerton, Steven D. ; Remien, Robert H. ; Rhodes, Fen ; Song, Juwon ; Steward, Wayne T. ; Tross, Susan ; Weinhardt, Lance S. ; Weiss, Robert ; Wolfe, Hannah ; Wolfe, Rachel ; Wong, F. Lennie ; Batterham, Philip ; Comulada, W. Scott ; Rogers, Tyson ; Zhao, Yu ; Correale, Jackie ; Hackl, Kristin ; Hong, Daniel ; Huchting, Karen ; Mickalian, Joanne D. ; Peterson, Margaret ; Gordon, Christopher M. ; Rausch, Dianne ; Stover, Ellen. / Effects of a behavioral intervention to reduce risk of transmission among people living with HIV : The Healthy Living Project randomized controlled study. In: Journal of Acquired Immune Deficiency Syndromes. 2007 ; Vol. 44, No. 2. pp. 213-221.
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T1 - Effects of a behavioral intervention to reduce risk of transmission among people living with HIV

T2 - The Healthy Living Project randomized controlled study

AU - Morin, Stephen F.

AU - Chesney, Margaret A.

AU - Ehrhardt, Anke A.

AU - Kelly, Jeffrey A.

AU - Pequegnat, Willo

AU - Rotheram-Borus, Mary Jane

AU - Afifi, Abdelmonem A.

AU - Benotsch, Eric G.

AU - Brondino, Michael J.

AU - Catz, Sheryl L

AU - Charlebois, Edwin D.

AU - Cumberland, William G.

AU - DesJarlais, Don C.

AU - Duan, Naihua

AU - Exner, Theresa M.

AU - Goldstein, Rise B.

AU - Gore-Felton, Cheryl

AU - Hirky, A. Elizabeth

AU - Johnson, Mallory O.

AU - Kertzner, Robert M.

AU - Kirshenbaum, Sheri B.

AU - Kittel, Lauren E.

AU - Klitzman, Robert

AU - Lee, Martha

AU - Levin, Bruce

AU - Lightfoot, Marguerita

AU - Pinkerton, Steven D.

AU - Remien, Robert H.

AU - Rhodes, Fen

AU - Song, Juwon

AU - Steward, Wayne T.

AU - Tross, Susan

AU - Weinhardt, Lance S.

AU - Weiss, Robert

AU - Wolfe, Hannah

AU - Wolfe, Rachel

AU - Wong, F. Lennie

AU - Batterham, Philip

AU - Comulada, W. Scott

AU - Rogers, Tyson

AU - Zhao, Yu

AU - Correale, Jackie

AU - Hackl, Kristin

AU - Hong, Daniel

AU - Huchting, Karen

AU - Mickalian, Joanne D.

AU - Peterson, Margaret

AU - Gordon, Christopher M.

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AU - Stover, Ellen

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KW - Prevention case management

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