Abstract
We examined the effects of 4-aminopyridine (4-AP) on calcium conductance mechanisms in cultured mouse spinal cord neurons. At low concentrations (≤ 1 mM), 4-AP enhanced Ca2+-dependent transmitter release and prolonged the duration of Ca2+-dependent action potentials. Voltage clamp studies indicated that 4-AP directly facilitates Ca2+ entry through voltage sensitive channels apart from an effect on K+ currents. These results may help to explain why the drug promotes Ca2+-dependent transmitter release at peripheral and central synapses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 180-185 |
| Number of pages | 6 |
| Journal | Brain Research |
| Volume | 280 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 28 1983 |
| Externally published | Yes |
Keywords
- 4-aminopyridine
- neuronal cell culture
- voltage clamp
- voltage-dependent calcium channel
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
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Rogawski, M. A., & Barker, J. L. (1983). Effects of 4-aminopyridine on calcium action potentials and calcium current under voltage clamp in spinal neurons. Brain Research, 280(1), 180-185. https://doi.org/10.1016/0006-8993(83)91190-3