Effects of 4-aminopyridine on calcium action potentials and calcium current under voltage clamp in spinal neurons

Michael A Rogawski, Jeffery L. Barker

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

We examined the effects of 4-aminopyridine (4-AP) on calcium conductance mechanisms in cultured mouse spinal cord neurons. At low concentrations (≤ 1 mM), 4-AP enhanced Ca2+-dependent transmitter release and prolonged the duration of Ca2+-dependent action potentials. Voltage clamp studies indicated that 4-AP directly facilitates Ca2+ entry through voltage sensitive channels apart from an effect on K+ currents. These results may help to explain why the drug promotes Ca2+-dependent transmitter release at peripheral and central synapses.

Original languageEnglish (US)
Pages (from-to)180-185
Number of pages6
JournalBrain Research
Volume280
Issue number1
DOIs
StatePublished - Nov 28 1983
Externally publishedYes

Keywords

  • 4-aminopyridine
  • neuronal cell culture
  • voltage clamp
  • voltage-dependent calcium channel

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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