Effects of 2 G on adiposity, leptin, lipoprotein lipase, and uncoupling protein-1 in lean and obese Zucker rats

L. Elisabeth Warren, Barbara A Horwitz, Jock S. Hamilton, Charles A. Fuller

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Male Zucker rats were exposed to 2 G for 8 wk to test the hypothesis that the leptin regulatory pathway contributes to recovery from effects of 2 G on feeding, growth, and nutrient partitioning. After initial hypophagia, body massindependent food intake of the lean rats exposed to 2 G surpassed that of the lean rats maintained at 1 G, but food intake of the obese rats exposed to 2 G remained low. After 8 wk at 2 G, body mass and carcass fat were less in both genotypes. Leptin and percent fat were lower in lean rats exposed to 2 G vs. 1 G but did not differ in obese rats exposed to 2 G vs. 1 G. Although exposure to 2 G did not alter uncoupling protein-1 levels, it did elicit white fat pad-specific changes in lipoprotein lipase activity in obese but not lean rats. We conclude that 2 G affects both genotypes but that the lean Zucker rats recover their food intake and growth rate and retain "normal" lipoprotein lipase activity to a greater degree than do the obese rats, emphasizing the importance of a functional leptin regulatory pathway in this acclimation.

Original languageEnglish (US)
Pages (from-to)606-614
Number of pages9
JournalJournal of Applied Physiology
Volume90
Issue number2
StatePublished - 2001

Keywords

  • Body mass
  • Centrifugation
  • Fat metabolism
  • Food intake
  • Gravity

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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    Elisabeth Warren, L., Horwitz, B. A., Hamilton, J. S., & Fuller, C. A. (2001). Effects of 2 G on adiposity, leptin, lipoprotein lipase, and uncoupling protein-1 in lean and obese Zucker rats. Journal of Applied Physiology, 90(2), 606-614.