Effects of 13-cis-retinoic acid on hindbrain and craniofacial morphogenesis in long-tailed macaques (Macaca fascicularis)

Norbert Makori, Pamela E. Peterson, Thomas N. Blankenship, Lisa Dillard-Telm, Hans Hummler, Andrew G Hendrickx

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hindbrain and craniofacial development during early organogenesis was studied in normal and retinoic acid-exposed Macaca fascicularis embryos. 13-cis-retinoic acid impaired hindbrain segmentation as evidenced by compression of rhombomeres 1 to 5. Immunolocalization with the Hoxb-1 gene product along with quantitative measurements demonstrated that rhombomere 4 was particularly vulnerable to size reduction. Accompanying malformations of cranial neural crest cell migration patterns involved reduction and/or delay in pre- and post-otic placode crest cell populations that contribute to the pharyngeal arches and provide the developmental framework for the craniofacial region. The first and second pharyngeal arches were partially fused and the second arch was markedly reduced in size. The otocyst was delayed in development and shifted rostrolaterally relative to the hindbrain. These combined changes in the hindbrain, neural crest, and pharyngeal arches contribute to the craniofacial malformations observed in the retinoic acid malformation syndrome manifested in the macaque fetus.

Original languageEnglish (US)
Pages (from-to)210-219
Number of pages10
JournalJournal of Medical Primatology
Volume27
Issue number4
StatePublished - 1998

Fingerprint

Isotretinoin
Rhombencephalon
Macaca fascicularis
retinoic acid
Macaca
Branchial Region
Morphogenesis
morphogenesis
brain
neural crest
Neural Crest
Tretinoin
Ear
ears
Organogenesis
organogenesis
cell movement
Cell Movement
fetus
early development

Keywords

  • Hoxb-1
  • Neural crest
  • Nonhuman primate
  • Otocyst
  • Pharyngeal arches
  • Rhombencephalon
  • Segmentation

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Makori, N., Peterson, P. E., Blankenship, T. N., Dillard-Telm, L., Hummler, H., & Hendrickx, A. G. (1998). Effects of 13-cis-retinoic acid on hindbrain and craniofacial morphogenesis in long-tailed macaques (Macaca fascicularis). Journal of Medical Primatology, 27(4), 210-219.

Effects of 13-cis-retinoic acid on hindbrain and craniofacial morphogenesis in long-tailed macaques (Macaca fascicularis). / Makori, Norbert; Peterson, Pamela E.; Blankenship, Thomas N.; Dillard-Telm, Lisa; Hummler, Hans; Hendrickx, Andrew G.

In: Journal of Medical Primatology, Vol. 27, No. 4, 1998, p. 210-219.

Research output: Contribution to journalArticle

Makori, N, Peterson, PE, Blankenship, TN, Dillard-Telm, L, Hummler, H & Hendrickx, AG 1998, 'Effects of 13-cis-retinoic acid on hindbrain and craniofacial morphogenesis in long-tailed macaques (Macaca fascicularis)', Journal of Medical Primatology, vol. 27, no. 4, pp. 210-219.
Makori N, Peterson PE, Blankenship TN, Dillard-Telm L, Hummler H, Hendrickx AG. Effects of 13-cis-retinoic acid on hindbrain and craniofacial morphogenesis in long-tailed macaques (Macaca fascicularis). Journal of Medical Primatology. 1998;27(4):210-219.
Makori, Norbert ; Peterson, Pamela E. ; Blankenship, Thomas N. ; Dillard-Telm, Lisa ; Hummler, Hans ; Hendrickx, Andrew G. / Effects of 13-cis-retinoic acid on hindbrain and craniofacial morphogenesis in long-tailed macaques (Macaca fascicularis). In: Journal of Medical Primatology. 1998 ; Vol. 27, No. 4. pp. 210-219.
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