Abstract
Hindbrain and craniofacial development during early organogenesis was studied in normal and retinoic acid-exposed Macaca fascicularis embryos. 13-cis-retinoic acid impaired hindbrain segmentation as evidenced by compression of rhombomeres 1 to 5. Immunolocalization with the Hoxb-1 gene product along with quantitative measurements demonstrated that rhombomere 4 was particularly vulnerable to size reduction. Accompanying malformations of cranial neural crest cell migration patterns involved reduction and/or delay in pre- and post-otic placode crest cell populations that contribute to the pharyngeal arches and provide the developmental framework for the craniofacial region. The first and second pharyngeal arches were partially fused and the second arch was markedly reduced in size. The otocyst was delayed in development and shifted rostrolaterally relative to the hindbrain. These combined changes in the hindbrain, neural crest, and pharyngeal arches contribute to the craniofacial malformations observed in the retinoic acid malformation syndrome manifested in the macaque fetus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 210-219 |
| Number of pages | 10 |
| Journal | Journal of Medical Primatology |
| Volume | 27 |
| Issue number | 4 |
| State | Published - 1998 |
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Keywords
- Hoxb-1
- Neural crest
- Nonhuman primate
- Otocyst
- Pharyngeal arches
- Rhombencephalon
- Segmentation
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Effects of 13-cis-retinoic acid on hindbrain and craniofacial morphogenesis in long-tailed macaques (Macaca fascicularis). / Makori, Norbert; Peterson, Pamela E.; Blankenship, Thomas N.; Dillard-Telm, Lisa; Hummler, Hans; Hendrickx, Andrew G.
In: Journal of Medical Primatology, Vol. 27, No. 4, 1998, p. 210-219.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of 13-cis-retinoic acid on hindbrain and craniofacial morphogenesis in long-tailed macaques (Macaca fascicularis)
AU - Makori, Norbert
AU - Peterson, Pamela E.
AU - Blankenship, Thomas N.
AU - Dillard-Telm, Lisa
AU - Hummler, Hans
AU - Hendrickx, Andrew G
PY - 1998
Y1 - 1998
N2 - Hindbrain and craniofacial development during early organogenesis was studied in normal and retinoic acid-exposed Macaca fascicularis embryos. 13-cis-retinoic acid impaired hindbrain segmentation as evidenced by compression of rhombomeres 1 to 5. Immunolocalization with the Hoxb-1 gene product along with quantitative measurements demonstrated that rhombomere 4 was particularly vulnerable to size reduction. Accompanying malformations of cranial neural crest cell migration patterns involved reduction and/or delay in pre- and post-otic placode crest cell populations that contribute to the pharyngeal arches and provide the developmental framework for the craniofacial region. The first and second pharyngeal arches were partially fused and the second arch was markedly reduced in size. The otocyst was delayed in development and shifted rostrolaterally relative to the hindbrain. These combined changes in the hindbrain, neural crest, and pharyngeal arches contribute to the craniofacial malformations observed in the retinoic acid malformation syndrome manifested in the macaque fetus.
AB - Hindbrain and craniofacial development during early organogenesis was studied in normal and retinoic acid-exposed Macaca fascicularis embryos. 13-cis-retinoic acid impaired hindbrain segmentation as evidenced by compression of rhombomeres 1 to 5. Immunolocalization with the Hoxb-1 gene product along with quantitative measurements demonstrated that rhombomere 4 was particularly vulnerable to size reduction. Accompanying malformations of cranial neural crest cell migration patterns involved reduction and/or delay in pre- and post-otic placode crest cell populations that contribute to the pharyngeal arches and provide the developmental framework for the craniofacial region. The first and second pharyngeal arches were partially fused and the second arch was markedly reduced in size. The otocyst was delayed in development and shifted rostrolaterally relative to the hindbrain. These combined changes in the hindbrain, neural crest, and pharyngeal arches contribute to the craniofacial malformations observed in the retinoic acid malformation syndrome manifested in the macaque fetus.
KW - Hoxb-1
KW - Neural crest
KW - Nonhuman primate
KW - Otocyst
KW - Pharyngeal arches
KW - Rhombencephalon
KW - Segmentation
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UR - http://www.scopus.com/inward/citedby.url?scp=0032130725&partnerID=8YFLogxK
M3 - Article
C2 - 9879862
AN - SCOPUS:0032130725
VL - 27
SP - 210
EP - 219
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
SN - 0047-2565
IS - 4
ER -