Abstract
In vivo solute clearances can be estimated from dialyzer blood (Q b) and dialysate (Qd) flow rates and a solute- and dialyzer-specific overall permeability membrane area product (KoA). However, these calculations require knowledge of the flow rate of the effective solute distribution volume in the flowing bloodstream (Qe) in order to calculate in vivo clearances and KoAs. We have determined Qe for urea, creatinine, and inorganic phosphorus from changes in concentrations across the blood compartment and mass balance between the blood and dialysate streams. We made four serial measurements over one dialysis in 23 patients and found that Qeu equals the total blood water flow rate, Q ecr equals the plasma water flow rate plus 61% of red cell Water flow rate, and QeiP is limited to the plasma water flow rate. Equations are derived to calculate Qe for each of these solutes from Qb and hematocrit and in vivo KoAs for each solute were calculated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 474-476 |
| Number of pages | 3 |
| Journal | Seminars in Dialysis |
| Volume | 16 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 2003 |
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ASJC Scopus subject areas
- Nephrology
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Effective Diffusion Volume Flow Rates (Qe) for Urea, Creatinine, and Inorganic Phosphorous (Qeu, Qecr, QeiP) during Hemodialysis. / Gotch, Frank A.; Panlilio, Froilan; Sergeyeva, Olga; Rosales, Laura; Folden, Tom; Kaysen, George; Levin, Nathan.
In: Seminars in Dialysis, Vol. 16, No. 6, 11.2003, p. 474-476.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Effective Diffusion Volume Flow Rates (Qe) for Urea, Creatinine, and Inorganic Phosphorous (Qeu, Qecr, QeiP) during Hemodialysis
AU - Gotch, Frank A.
AU - Panlilio, Froilan
AU - Sergeyeva, Olga
AU - Rosales, Laura
AU - Folden, Tom
AU - Kaysen, George
AU - Levin, Nathan
PY - 2003/11
Y1 - 2003/11
N2 - In vivo solute clearances can be estimated from dialyzer blood (Q b) and dialysate (Qd) flow rates and a solute- and dialyzer-specific overall permeability membrane area product (KoA). However, these calculations require knowledge of the flow rate of the effective solute distribution volume in the flowing bloodstream (Qe) in order to calculate in vivo clearances and KoAs. We have determined Qe for urea, creatinine, and inorganic phosphorus from changes in concentrations across the blood compartment and mass balance between the blood and dialysate streams. We made four serial measurements over one dialysis in 23 patients and found that Qeu equals the total blood water flow rate, Q ecr equals the plasma water flow rate plus 61% of red cell Water flow rate, and QeiP is limited to the plasma water flow rate. Equations are derived to calculate Qe for each of these solutes from Qb and hematocrit and in vivo KoAs for each solute were calculated.
AB - In vivo solute clearances can be estimated from dialyzer blood (Q b) and dialysate (Qd) flow rates and a solute- and dialyzer-specific overall permeability membrane area product (KoA). However, these calculations require knowledge of the flow rate of the effective solute distribution volume in the flowing bloodstream (Qe) in order to calculate in vivo clearances and KoAs. We have determined Qe for urea, creatinine, and inorganic phosphorus from changes in concentrations across the blood compartment and mass balance between the blood and dialysate streams. We made four serial measurements over one dialysis in 23 patients and found that Qeu equals the total blood water flow rate, Q ecr equals the plasma water flow rate plus 61% of red cell Water flow rate, and QeiP is limited to the plasma water flow rate. Equations are derived to calculate Qe for each of these solutes from Qb and hematocrit and in vivo KoAs for each solute were calculated.
UR - http://www.scopus.com/inward/record.url?scp=0348109295&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0348109295&partnerID=8YFLogxK
U2 - 10.1046/j.1525-139X.2003.16102.x
DO - 10.1046/j.1525-139X.2003.16102.x
M3 - Article
C2 - 14629609
AN - SCOPUS:0348109295
VL - 16
SP - 474
EP - 476
JO - Seminars in Dialysis
JF - Seminars in Dialysis
SN - 0894-0959
IS - 6
ER -