Effect of zinc sulfate and acetylcysteine on experimental gastric ulcer: In vitro study

Nirmal S Mann, Surinder K Mann, P. N. Brawn, B. Weaver

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A small ulcer produced in vitro by monopolar electrocoagulation on endoscopically obtained human antral biopsies and incubated in Trowel T-8 medium at 37°C for 8 h has many histologic features of chronic gastric ulcer in man. Zinc sulfate and acetylcysteine in low concentrations had a significant healing effect in this ulcer model. Since the beneficial effect of zinc sulfate and acetylcysteine was counteracted by N-ethylmaleimide, a known blocker of sulfhydryl compounds, the beneficial effect of these two compounds probably was mediated through sulfhydryl compounds. Using special stain, N-(4-aminophenyl)maleimide, the sulfhydryl groups were localized in the epithelial cells of the surface layer and gastric glands.

Original languageEnglish (US)
Pages (from-to)108-113
Number of pages6
JournalDigestion
Volume53
Issue number1-2
StatePublished - 1992
Externally publishedYes

Keywords

  • In vitro chronic ulcer
  • N-(4-aminophenyl)-maleimide stain
  • N-ethylmaleimide
  • Organ culture
  • Sulfhydryl compounds

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Effect of zinc sulfate and acetylcysteine on experimental gastric ulcer: In vitro study'. Together they form a unique fingerprint.

  • Cite this