Effect of zinc sulfate and acetylcysteine on experimental gastric ulcer: In vitro study

Nirmal S Mann, Surinder K Mann, P. N. Brawn, B. Weaver

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A small ulcer produced in vitro by monopolar electrocoagulation on endoscopically obtained human antral biopsies and incubated in Trowel T-8 medium at 37°C for 8 h has many histologic features of chronic gastric ulcer in man. Zinc sulfate and acetylcysteine in low concentrations had a significant healing effect in this ulcer model. Since the beneficial effect of zinc sulfate and acetylcysteine was counteracted by N-ethylmaleimide, a known blocker of sulfhydryl compounds, the beneficial effect of these two compounds probably was mediated through sulfhydryl compounds. Using special stain, N-(4-aminophenyl)maleimide, the sulfhydryl groups were localized in the epithelial cells of the surface layer and gastric glands.

Original languageEnglish (US)
Pages (from-to)108-113
Number of pages6
JournalDigestion
Volume53
Issue number1-2
StatePublished - 1992
Externally publishedYes

Fingerprint

Zinc Sulfate
Acetylcysteine
Stomach Ulcer
Sulfhydryl Compounds
Ulcer
Electrocoagulation
Ethylmaleimide
Gastric Mucosa
Coloring Agents
Epithelial Cells
Biopsy
In Vitro Techniques
N-(4-aminophenyl)maleimide
Antral

Keywords

  • In vitro chronic ulcer
  • N-(4-aminophenyl)-maleimide stain
  • N-ethylmaleimide
  • Organ culture
  • Sulfhydryl compounds

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effect of zinc sulfate and acetylcysteine on experimental gastric ulcer : In vitro study. / Mann, Nirmal S; Mann, Surinder K; Brawn, P. N.; Weaver, B.

In: Digestion, Vol. 53, No. 1-2, 1992, p. 108-113.

Research output: Contribution to journalArticle

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