Abstract
We measured plasma concentrations of alfentanil in two horses after three different randomly ordered treatments. Each horse received halothane in oxygen by mask followed by a bolus dose of alfentanil 60 μg kg-1 i. v., halothane in oxygen by mask followed by an i.v. alfentanil infusion for 120 min and xylazine and ketamine followed by halothane and a bolus dose of alfentanil 60 μg kg-1 i.v. Halothane was maintained at 1.05-1.07% end-tidal concentration with a Paco2 of 6-7.3 kPa. The plasma concentration-time curves were similar after bolus and infusion doses of alfentanil with halothane and could be fitted to a two-compartment open model. A plateau was noted in the plasma concentration-time curve in the presence of xylazine-ketamine which could not be modelled adequately, but suggested a three-compartment open model with an additional input component. (Br. J. Anaesth. 1994; 72: 345-347)
| Original language | English (US) |
|---|---|
| Pages (from-to) | 345-347 |
| Number of pages | 3 |
| Journal | British Journal of Anaesthesia |
| Volume | 72 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1994 |
Keywords
- Pharmacokinetics alfentanil
ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Mathematics(all)
- Statistics and Probability
- Agricultural and Biological Sciences (miscellaneous)
- Anesthesiology and Pain Medicine