Abstract
We measured plasma concentrations of alfentanil in two horses after three different randomly ordered treatments. Each horse received halothane in oxygen by mask followed by a bolus dose of alfentanil 60 μg kg-1 i. v., halothane in oxygen by mask followed by an i.v. alfentanil infusion for 120 min and xylazine and ketamine followed by halothane and a bolus dose of alfentanil 60 μg kg-1 i.v. Halothane was maintained at 1.05-1.07% end-tidal concentration with a Paco2 of 6-7.3 kPa. The plasma concentration-time curves were similar after bolus and infusion doses of alfentanil with halothane and could be fitted to a two-compartment open model. A plateau was noted in the plasma concentration-time curve in the presence of xylazine-ketamine which could not be modelled adequately, but suggested a three-compartment open model with an additional input component. (Br. J. Anaesth. 1994; 72: 345-347)
| Original language | English (US) |
|---|---|
| Pages (from-to) | 345-347 |
| Number of pages | 3 |
| Journal | British Journal of Anaesthesia |
| Volume | 72 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1994 |
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Keywords
- Pharmacokinetics alfentanil
ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Mathematics(all)
- Statistics and Probability
- Agricultural and Biological Sciences (miscellaneous)
- Anesthesiology and Pain Medicine
Cite this
Effect of xylazine and ketamine on the pharmacokinetics of alfentanil during halothane anaesthesia. / Pascoe, Peter J; Black, W. D.; Steffey, Eugene.
In: British Journal of Anaesthesia, Vol. 72, No. 3, 03.1994, p. 345-347.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of xylazine and ketamine on the pharmacokinetics of alfentanil during halothane anaesthesia
AU - Pascoe, Peter J
AU - Black, W. D.
AU - Steffey, Eugene
PY - 1994/3
Y1 - 1994/3
N2 - We measured plasma concentrations of alfentanil in two horses after three different randomly ordered treatments. Each horse received halothane in oxygen by mask followed by a bolus dose of alfentanil 60 μg kg-1 i. v., halothane in oxygen by mask followed by an i.v. alfentanil infusion for 120 min and xylazine and ketamine followed by halothane and a bolus dose of alfentanil 60 μg kg-1 i.v. Halothane was maintained at 1.05-1.07% end-tidal concentration with a Paco2 of 6-7.3 kPa. The plasma concentration-time curves were similar after bolus and infusion doses of alfentanil with halothane and could be fitted to a two-compartment open model. A plateau was noted in the plasma concentration-time curve in the presence of xylazine-ketamine which could not be modelled adequately, but suggested a three-compartment open model with an additional input component. (Br. J. Anaesth. 1994; 72: 345-347)
AB - We measured plasma concentrations of alfentanil in two horses after three different randomly ordered treatments. Each horse received halothane in oxygen by mask followed by a bolus dose of alfentanil 60 μg kg-1 i. v., halothane in oxygen by mask followed by an i.v. alfentanil infusion for 120 min and xylazine and ketamine followed by halothane and a bolus dose of alfentanil 60 μg kg-1 i.v. Halothane was maintained at 1.05-1.07% end-tidal concentration with a Paco2 of 6-7.3 kPa. The plasma concentration-time curves were similar after bolus and infusion doses of alfentanil with halothane and could be fitted to a two-compartment open model. A plateau was noted in the plasma concentration-time curve in the presence of xylazine-ketamine which could not be modelled adequately, but suggested a three-compartment open model with an additional input component. (Br. J. Anaesth. 1994; 72: 345-347)
KW - Pharmacokinetics alfentanil
UR - http://www.scopus.com/inward/record.url?scp=0028334954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028334954&partnerID=8YFLogxK
U2 - 10.1093/bja/72.3.345
DO - 10.1093/bja/72.3.345
M3 - Article
VL - 72
SP - 345
EP - 347
JO - British Journal of Anaesthesia
JF - British Journal of Anaesthesia
SN - 0007-0912
IS - 3
ER -