Effect of walnut (Juglans regia) polyphenolic compounds on ovalbumin-specific IgE induction in female BALB/c mice

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

English walnuts are implicated in severe, IgE-mediated food allergy in humans. We sought to determine if polyphenolic compounds extracted from the edible nut could promote IgE production to a coadministered allergen. BALB/c mice were sensitized to ovalbumin (OVA) with or without alum (AL) or polyphenolic-enriched extract via intraperitoneal injection. Serum was analyzed for total IgE and OVA-specific IgE, IgG1, and IgG2a/2b. Coadministration of walnut polyphenolic-enriched extract with antigen and AL increased serum concentrations of antigen-specific IgE and IgG1. When AL was excluded from the injections, polyphenolic extract tended to enhance OVA-specific IgE and IgG1 over levels induced by OVA alone, but the increase did not reach significance. Serum IgG2a/2b levels were similar between mice receiving OVA/AL and OVA/AL with polyphenolics. Thus, walnut polyphenolic extract enhanced the Th2-skewing effect of an aluminum hydroxide adjuvant. This indicates that walnut polyphenolic compounds may play a role in allergic sensitization of genetically predisposed individuals.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages58-69
Number of pages12
Volume1190
DOIs
StatePublished - Mar 2010

Publication series

NameAnnals of the New York Academy of Sciences
Volume1190
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Polyphenolic compounds
Juglans
Ovalbumin
Immunoglobulin E
Immunoglobulin G
Serum
Allergies
Aluminum Hydroxide
Antigens
Nuts
Food Hypersensitivity
Intraperitoneal Injections
Allergens
Injections

Keywords

  • Allergy
  • Antibodies
  • Food allergy
  • Food matrix
  • IgE
  • Juglans
  • Mouse
  • Polyphenol
  • Sensitization
  • Walnut

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Comstock, S. S., Gershwin, L. J., & Teuber, S. S. (2010). Effect of walnut (Juglans regia) polyphenolic compounds on ovalbumin-specific IgE induction in female BALB/c mice. In Annals of the New York Academy of Sciences (Vol. 1190, pp. 58-69). (Annals of the New York Academy of Sciences; Vol. 1190). https://doi.org/10.1111/j.1749-6632.2009.05274.x

Effect of walnut (Juglans regia) polyphenolic compounds on ovalbumin-specific IgE induction in female BALB/c mice. / Comstock, Sarah S.; Gershwin, Laurel J; Teuber, Suzanne S.

Annals of the New York Academy of Sciences. Vol. 1190 2010. p. 58-69 (Annals of the New York Academy of Sciences; Vol. 1190).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Comstock, SS, Gershwin, LJ & Teuber, SS 2010, Effect of walnut (Juglans regia) polyphenolic compounds on ovalbumin-specific IgE induction in female BALB/c mice. in Annals of the New York Academy of Sciences. vol. 1190, Annals of the New York Academy of Sciences, vol. 1190, pp. 58-69. https://doi.org/10.1111/j.1749-6632.2009.05274.x
Comstock SS, Gershwin LJ, Teuber SS. Effect of walnut (Juglans regia) polyphenolic compounds on ovalbumin-specific IgE induction in female BALB/c mice. In Annals of the New York Academy of Sciences. Vol. 1190. 2010. p. 58-69. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2009.05274.x
Comstock, Sarah S. ; Gershwin, Laurel J ; Teuber, Suzanne S. / Effect of walnut (Juglans regia) polyphenolic compounds on ovalbumin-specific IgE induction in female BALB/c mice. Annals of the New York Academy of Sciences. Vol. 1190 2010. pp. 58-69 (Annals of the New York Academy of Sciences).
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