@inproceedings{411d9ad93a1b42ed91f67957b7383200,
title = "Effect of walnut (Juglans regia) polyphenolic compounds on ovalbumin-specific IgE induction in female BALB/c mice",
abstract = "English walnuts are implicated in severe, IgE-mediated food allergy in humans. We sought to determine if polyphenolic compounds extracted from the edible nut could promote IgE production to a coadministered allergen. BALB/c mice were sensitized to ovalbumin (OVA) with or without alum (AL) or polyphenolic-enriched extract via intraperitoneal injection. Serum was analyzed for total IgE and OVA-specific IgE, IgG1, and IgG2a/2b. Coadministration of walnut polyphenolic-enriched extract with antigen and AL increased serum concentrations of antigen-specific IgE and IgG1. When AL was excluded from the injections, polyphenolic extract tended to enhance OVA-specific IgE and IgG1 over levels induced by OVA alone, but the increase did not reach significance. Serum IgG2a/2b levels were similar between mice receiving OVA/AL and OVA/AL with polyphenolics. Thus, walnut polyphenolic extract enhanced the Th2-skewing effect of an aluminum hydroxide adjuvant. This indicates that walnut polyphenolic compounds may play a role in allergic sensitization of genetically predisposed individuals.",
keywords = "Allergy, Antibodies, Food allergy, Food matrix, IgE, Juglans, Mouse, Polyphenol, Sensitization, Walnut",
author = "Comstock, {Sarah S.} and Gershwin, {Laurel J} and Teuber, {Suzanne S}",
year = "2010",
month = mar,
doi = "10.1111/j.1749-6632.2009.05274.x",
language = "English (US)",
isbn = "9781573317900",
volume = "1190",
series = "Annals of the New York Academy of Sciences",
pages = "58--69",
booktitle = "Annals of the New York Academy of Sciences",
}