Effect of varying dietary iron and zinc levels on tissue concentrations in the rat

Bo Lonnerdal, L. Davidson, C. L. Keen

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The results show that a negative interaction between dietary iron and zinc can be reflected in hepatic and mucosal concentrations of the elements. However, this interaction is mainly observed when the concentration of one element is high and the other is low. The mechanism underlying the interaction between iron and zinc has not yet been delineated, although preliminary data suggest that it may involve competition for mucosal transferrin binding sites. We have recently noted similar observations when studying the negative interaction between dietary zinc anc copper. These results show the importance of considering the potential negative impact of supplementing one mineral on the bioavailability and retention of another which has similar physical-chemical characteristics. This point should be taken into consideration in instances when iron supplementation is routinely recommended, such as during pregnancy, infancy and childhood in which populations are also believed to be at risk for zinc deficiency.

Original languageEnglish (US)
Pages (from-to)S-277-S-280
JournalNutrition Research
Issue numberSUPPL. 1
StatePublished - 1985

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics


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