Effect of vaccination with Brucella abortus strain RB51 on heifers and pregnant cattle

Francisco A Uzal, L. Samartino, G. Schurig, A. Carrasco, K. Nielsen, R. F. Cabrera, H. R. Taddeo

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Thirteen cows, which had been vaccinated as calves with strain 19, were revaccinated twice or three times as adults with 1 x 109 cfu of B. abortus strain RB51. Their serological responses following adult vaccination remained negative to conventional brucellosis surveillance tests. Vaccination with strain RB51 during the eighth month of pregnancy did not induce abortion, although strain RB51 was recovered from milk for up to 69 days after vaccination. In a parallel study, thirteen 8- to 10-month-old heifers were vaccinated as calves with 109 cfu of strain RB51. The heifers remained seronegative to conventional brucellosis surveillance tests but antibody responses to RB51 could be demonstrated using an indirect ELISA. This study showed that multiple vaccination with strain RB51 did not induce seroconversion to brucellosis surveillance tests. In addition, this study suggests that 109 cfu of strain RB51 is safe for use in pregnant cattle.

Original languageEnglish (US)
Pages (from-to)143-151
Number of pages9
JournalVeterinary Research Communications
Issue number3
StatePublished - 2000
Externally publishedYes


  • Brucellosis
  • Cattle
  • Safety
  • Seroconversion
  • Vaccine

ASJC Scopus subject areas

  • veterinary(all)


Dive into the research topics of 'Effect of vaccination with Brucella abortus strain RB51 on heifers and pregnant cattle'. Together they form a unique fingerprint.

Cite this