Effect of treatment of Strongyloides infection on HTLV-1 expression in a patient with adult T-cell leukemia

Lee Ratner, Christian Grant, Bevin Zimmerman, Joseph Fritz, Gary Weil, Alex Denes, Rama Suresh, Nancy Campbell, Steve Jacobson, Michael Dale Lairmore

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia-lymphoma (ATLL) in about 5% of infected individuals. Coinfection by Strongyloides stercoralis has been suggested to be a cofactor for development of ATLL. We describe a patient who presented with HTLV-1-associated chronic ATLL and Strongyloides infection. Studies of this patient's viral RNA levels demonstrated stimulation of HTLV-1 replication by Strongyloides, which resolved with anti-helminthic therapy. This case provides support for the hypothesis that Strongyloides is a cofactor for ATLL via T-cell stimulation.

Original languageEnglish (US)
Pages (from-to)929-931
Number of pages3
JournalAmerican Journal of Hematology
Volume82
Issue number10
DOIs
StatePublished - Oct 2007
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Hematology

Cite this

Ratner, L., Grant, C., Zimmerman, B., Fritz, J., Weil, G., Denes, A., Suresh, R., Campbell, N., Jacobson, S., & Lairmore, M. D. (2007). Effect of treatment of Strongyloides infection on HTLV-1 expression in a patient with adult T-cell leukemia. American Journal of Hematology, 82(10), 929-931. https://doi.org/10.1002/ajh.20929