Effect of treatment of Strongyloides infection on HTLV-1 expression in a patient with adult T-cell leukemia

Lee Ratner, Christian Grant, Bevin Zimmerman, Joseph Fritz, Gary Weil, Alex Denes, Rama Suresh, Nancy Campbell, Steve Jacobson, Michael Dale Lairmore

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia-lymphoma (ATLL) in about 5% of infected individuals. Coinfection by Strongyloides stercoralis has been suggested to be a cofactor for development of ATLL. We describe a patient who presented with HTLV-1-associated chronic ATLL and Strongyloides infection. Studies of this patient's viral RNA levels demonstrated stimulation of HTLV-1 replication by Strongyloides, which resolved with anti-helminthic therapy. This case provides support for the hypothesis that Strongyloides is a cofactor for ATLL via T-cell stimulation.

Original languageEnglish (US)
Pages (from-to)929-931
Number of pages3
JournalAmerican Journal of Hematology
Volume82
Issue number10
DOIs
StatePublished - Oct 2007
Externally publishedYes

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Strongyloides
Deltaretrovirus
Adult T Cell Leukemia Lymphoma
Infection
Therapy with Helminths
T-Cell Prolymphocytic Leukemia
Strongyloides stercoralis
Viral RNA
Therapeutics
Virus Replication
Coinfection
T-Lymphocytes

ASJC Scopus subject areas

  • Hematology

Cite this

Effect of treatment of Strongyloides infection on HTLV-1 expression in a patient with adult T-cell leukemia. / Ratner, Lee; Grant, Christian; Zimmerman, Bevin; Fritz, Joseph; Weil, Gary; Denes, Alex; Suresh, Rama; Campbell, Nancy; Jacobson, Steve; Lairmore, Michael Dale.

In: American Journal of Hematology, Vol. 82, No. 10, 10.2007, p. 929-931.

Research output: Contribution to journalArticle

Ratner, L, Grant, C, Zimmerman, B, Fritz, J, Weil, G, Denes, A, Suresh, R, Campbell, N, Jacobson, S & Lairmore, MD 2007, 'Effect of treatment of Strongyloides infection on HTLV-1 expression in a patient with adult T-cell leukemia', American Journal of Hematology, vol. 82, no. 10, pp. 929-931. https://doi.org/10.1002/ajh.20929
Ratner, Lee ; Grant, Christian ; Zimmerman, Bevin ; Fritz, Joseph ; Weil, Gary ; Denes, Alex ; Suresh, Rama ; Campbell, Nancy ; Jacobson, Steve ; Lairmore, Michael Dale. / Effect of treatment of Strongyloides infection on HTLV-1 expression in a patient with adult T-cell leukemia. In: American Journal of Hematology. 2007 ; Vol. 82, No. 10. pp. 929-931.
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