Effect of transdermally administered fentanyl on the minimum alveolar concentration of isoflurane in cats

Michael Yackey, Jan Ilkiw, Peter J Pascoe, Linda D. Tripp

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: To determine the effect of two doses of fentanyl, administered transdermally, on the minimum alveolar concentration (MAC) of isoflurane in cats. Study design: Prospective, randomized study. Animals: Five healthy, spayed, female cats. Methods: Each cat was studied thrice with at least 2 weeks between each study. In study 1, the baseline isoflurane MAC was determined in triplicate for each cat. In studies 2 and 3, isoflurane MAC was determined 24 hours after placement of either a 25 or 50 μg hour-1 fentanyl patch. In each MAC study, cats were instrumented to allow collection of arterial blood and measurement of arterial blood pressure. Twenty-four hours prior to studies 2 and 3, a catheter was placed and secured in the jugular vein and either a 25 or 50 μg hour-1 fentanyl patch was placed in random order on the left thorax. Blood samples for plasma fentanyl determination were collected prior to patch placement and at regular intervals up to 144 hours. After determination of MAC in studies 2 and 3, naloxone was administered as a bolus dose (0.1 mg kg-1) followed by an infusion (1 mg kg -1 hour-1) and MAC redetermined. Results: The baseline isoflurane MAC was 1.51 ± 0.21% (mean ± SD). Fentanyl (25 and 50 μg hour-1) administered transdermally significantly reduced MAC to 1.25 ± 0.26 and 1.22 ± 0.16%, respectively. These MAC reductions were not significantly different from each other. Isoflurane MAC determined during administration of fentanyl 25 μg hour-1 and naloxone (1.44 ± 0.16%) and fentanyl 50 μg hour-1 and naloxone (1.51 ± 0.19%) was not significantly different from baseline MAC (1.51 ± 0.21%). Conclusions and clinical relevance: Fentanyl patches are placed to provide long-lasting analgesia. In order to be effective postoperatively, fentanyl patches must be placed prior to surgery. Plasma fentanyl concentrations achieved intraoperatively decrease the need for potent inhalant anesthetics in cats.

Original languageEnglish (US)
Pages (from-to)183-189
Number of pages7
JournalVeterinary Anaesthesia and Analgesia
Volume31
Issue number3
DOIs
StatePublished - Jul 2004

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fentanyl
Isoflurane
isoflurane
Fentanyl
Cats
cats
naloxone
Naloxone
Jugular Veins
jugular vein
blood
thorax
dosage
analgesia
catheters
anesthetics
Analgesia
blood pressure
Anesthetics
Arterial Pressure

Keywords

  • Cats
  • Isoflurane
  • MAC reduction (minimum alveolar concentration)
  • Transdermal fentanyl

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effect of transdermally administered fentanyl on the minimum alveolar concentration of isoflurane in cats. / Yackey, Michael; Ilkiw, Jan; Pascoe, Peter J; Tripp, Linda D.

In: Veterinary Anaesthesia and Analgesia, Vol. 31, No. 3, 07.2004, p. 183-189.

Research output: Contribution to journalArticle

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title = "Effect of transdermally administered fentanyl on the minimum alveolar concentration of isoflurane in cats",
abstract = "Objective: To determine the effect of two doses of fentanyl, administered transdermally, on the minimum alveolar concentration (MAC) of isoflurane in cats. Study design: Prospective, randomized study. Animals: Five healthy, spayed, female cats. Methods: Each cat was studied thrice with at least 2 weeks between each study. In study 1, the baseline isoflurane MAC was determined in triplicate for each cat. In studies 2 and 3, isoflurane MAC was determined 24 hours after placement of either a 25 or 50 μg hour-1 fentanyl patch. In each MAC study, cats were instrumented to allow collection of arterial blood and measurement of arterial blood pressure. Twenty-four hours prior to studies 2 and 3, a catheter was placed and secured in the jugular vein and either a 25 or 50 μg hour-1 fentanyl patch was placed in random order on the left thorax. Blood samples for plasma fentanyl determination were collected prior to patch placement and at regular intervals up to 144 hours. After determination of MAC in studies 2 and 3, naloxone was administered as a bolus dose (0.1 mg kg-1) followed by an infusion (1 mg kg -1 hour-1) and MAC redetermined. Results: The baseline isoflurane MAC was 1.51 ± 0.21{\%} (mean ± SD). Fentanyl (25 and 50 μg hour-1) administered transdermally significantly reduced MAC to 1.25 ± 0.26 and 1.22 ± 0.16{\%}, respectively. These MAC reductions were not significantly different from each other. Isoflurane MAC determined during administration of fentanyl 25 μg hour-1 and naloxone (1.44 ± 0.16{\%}) and fentanyl 50 μg hour-1 and naloxone (1.51 ± 0.19{\%}) was not significantly different from baseline MAC (1.51 ± 0.21{\%}). Conclusions and clinical relevance: Fentanyl patches are placed to provide long-lasting analgesia. In order to be effective postoperatively, fentanyl patches must be placed prior to surgery. Plasma fentanyl concentrations achieved intraoperatively decrease the need for potent inhalant anesthetics in cats.",
keywords = "Cats, Isoflurane, MAC reduction (minimum alveolar concentration), Transdermal fentanyl",
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AU - Yackey, Michael

AU - Ilkiw, Jan

AU - Pascoe, Peter J

AU - Tripp, Linda D.

PY - 2004/7

Y1 - 2004/7

N2 - Objective: To determine the effect of two doses of fentanyl, administered transdermally, on the minimum alveolar concentration (MAC) of isoflurane in cats. Study design: Prospective, randomized study. Animals: Five healthy, spayed, female cats. Methods: Each cat was studied thrice with at least 2 weeks between each study. In study 1, the baseline isoflurane MAC was determined in triplicate for each cat. In studies 2 and 3, isoflurane MAC was determined 24 hours after placement of either a 25 or 50 μg hour-1 fentanyl patch. In each MAC study, cats were instrumented to allow collection of arterial blood and measurement of arterial blood pressure. Twenty-four hours prior to studies 2 and 3, a catheter was placed and secured in the jugular vein and either a 25 or 50 μg hour-1 fentanyl patch was placed in random order on the left thorax. Blood samples for plasma fentanyl determination were collected prior to patch placement and at regular intervals up to 144 hours. After determination of MAC in studies 2 and 3, naloxone was administered as a bolus dose (0.1 mg kg-1) followed by an infusion (1 mg kg -1 hour-1) and MAC redetermined. Results: The baseline isoflurane MAC was 1.51 ± 0.21% (mean ± SD). Fentanyl (25 and 50 μg hour-1) administered transdermally significantly reduced MAC to 1.25 ± 0.26 and 1.22 ± 0.16%, respectively. These MAC reductions were not significantly different from each other. Isoflurane MAC determined during administration of fentanyl 25 μg hour-1 and naloxone (1.44 ± 0.16%) and fentanyl 50 μg hour-1 and naloxone (1.51 ± 0.19%) was not significantly different from baseline MAC (1.51 ± 0.21%). Conclusions and clinical relevance: Fentanyl patches are placed to provide long-lasting analgesia. In order to be effective postoperatively, fentanyl patches must be placed prior to surgery. Plasma fentanyl concentrations achieved intraoperatively decrease the need for potent inhalant anesthetics in cats.

AB - Objective: To determine the effect of two doses of fentanyl, administered transdermally, on the minimum alveolar concentration (MAC) of isoflurane in cats. Study design: Prospective, randomized study. Animals: Five healthy, spayed, female cats. Methods: Each cat was studied thrice with at least 2 weeks between each study. In study 1, the baseline isoflurane MAC was determined in triplicate for each cat. In studies 2 and 3, isoflurane MAC was determined 24 hours after placement of either a 25 or 50 μg hour-1 fentanyl patch. In each MAC study, cats were instrumented to allow collection of arterial blood and measurement of arterial blood pressure. Twenty-four hours prior to studies 2 and 3, a catheter was placed and secured in the jugular vein and either a 25 or 50 μg hour-1 fentanyl patch was placed in random order on the left thorax. Blood samples for plasma fentanyl determination were collected prior to patch placement and at regular intervals up to 144 hours. After determination of MAC in studies 2 and 3, naloxone was administered as a bolus dose (0.1 mg kg-1) followed by an infusion (1 mg kg -1 hour-1) and MAC redetermined. Results: The baseline isoflurane MAC was 1.51 ± 0.21% (mean ± SD). Fentanyl (25 and 50 μg hour-1) administered transdermally significantly reduced MAC to 1.25 ± 0.26 and 1.22 ± 0.16%, respectively. These MAC reductions were not significantly different from each other. Isoflurane MAC determined during administration of fentanyl 25 μg hour-1 and naloxone (1.44 ± 0.16%) and fentanyl 50 μg hour-1 and naloxone (1.51 ± 0.19%) was not significantly different from baseline MAC (1.51 ± 0.21%). Conclusions and clinical relevance: Fentanyl patches are placed to provide long-lasting analgesia. In order to be effective postoperatively, fentanyl patches must be placed prior to surgery. Plasma fentanyl concentrations achieved intraoperatively decrease the need for potent inhalant anesthetics in cats.

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