Abstract
Objective: To determine the effect of two doses of fentanyl, administered transdermally, on the minimum alveolar concentration (MAC) of isoflurane in cats. Study design: Prospective, randomized study. Animals: Five healthy, spayed, female cats. Methods: Each cat was studied thrice with at least 2 weeks between each study. In study 1, the baseline isoflurane MAC was determined in triplicate for each cat. In studies 2 and 3, isoflurane MAC was determined 24 hours after placement of either a 25 or 50 μg hour-1 fentanyl patch. In each MAC study, cats were instrumented to allow collection of arterial blood and measurement of arterial blood pressure. Twenty-four hours prior to studies 2 and 3, a catheter was placed and secured in the jugular vein and either a 25 or 50 μg hour-1 fentanyl patch was placed in random order on the left thorax. Blood samples for plasma fentanyl determination were collected prior to patch placement and at regular intervals up to 144 hours. After determination of MAC in studies 2 and 3, naloxone was administered as a bolus dose (0.1 mg kg-1) followed by an infusion (1 mg kg -1 hour-1) and MAC redetermined. Results: The baseline isoflurane MAC was 1.51 ± 0.21% (mean ± SD). Fentanyl (25 and 50 μg hour-1) administered transdermally significantly reduced MAC to 1.25 ± 0.26 and 1.22 ± 0.16%, respectively. These MAC reductions were not significantly different from each other. Isoflurane MAC determined during administration of fentanyl 25 μg hour-1 and naloxone (1.44 ± 0.16%) and fentanyl 50 μg hour-1 and naloxone (1.51 ± 0.19%) was not significantly different from baseline MAC (1.51 ± 0.21%). Conclusions and clinical relevance: Fentanyl patches are placed to provide long-lasting analgesia. In order to be effective postoperatively, fentanyl patches must be placed prior to surgery. Plasma fentanyl concentrations achieved intraoperatively decrease the need for potent inhalant anesthetics in cats.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 183-189 |
| Number of pages | 7 |
| Journal | Veterinary Anaesthesia and Analgesia |
| Volume | 31 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 2004 |
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Keywords
- Cats
- Isoflurane
- MAC reduction (minimum alveolar concentration)
- Transdermal fentanyl
ASJC Scopus subject areas
- veterinary(all)
Cite this
Effect of transdermally administered fentanyl on the minimum alveolar concentration of isoflurane in cats. / Yackey, Michael; Ilkiw, Jan; Pascoe, Peter J; Tripp, Linda D.
In: Veterinary Anaesthesia and Analgesia, Vol. 31, No. 3, 07.2004, p. 183-189.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of transdermally administered fentanyl on the minimum alveolar concentration of isoflurane in cats
AU - Yackey, Michael
AU - Ilkiw, Jan
AU - Pascoe, Peter J
AU - Tripp, Linda D.
PY - 2004/7
Y1 - 2004/7
N2 - Objective: To determine the effect of two doses of fentanyl, administered transdermally, on the minimum alveolar concentration (MAC) of isoflurane in cats. Study design: Prospective, randomized study. Animals: Five healthy, spayed, female cats. Methods: Each cat was studied thrice with at least 2 weeks between each study. In study 1, the baseline isoflurane MAC was determined in triplicate for each cat. In studies 2 and 3, isoflurane MAC was determined 24 hours after placement of either a 25 or 50 μg hour-1 fentanyl patch. In each MAC study, cats were instrumented to allow collection of arterial blood and measurement of arterial blood pressure. Twenty-four hours prior to studies 2 and 3, a catheter was placed and secured in the jugular vein and either a 25 or 50 μg hour-1 fentanyl patch was placed in random order on the left thorax. Blood samples for plasma fentanyl determination were collected prior to patch placement and at regular intervals up to 144 hours. After determination of MAC in studies 2 and 3, naloxone was administered as a bolus dose (0.1 mg kg-1) followed by an infusion (1 mg kg -1 hour-1) and MAC redetermined. Results: The baseline isoflurane MAC was 1.51 ± 0.21% (mean ± SD). Fentanyl (25 and 50 μg hour-1) administered transdermally significantly reduced MAC to 1.25 ± 0.26 and 1.22 ± 0.16%, respectively. These MAC reductions were not significantly different from each other. Isoflurane MAC determined during administration of fentanyl 25 μg hour-1 and naloxone (1.44 ± 0.16%) and fentanyl 50 μg hour-1 and naloxone (1.51 ± 0.19%) was not significantly different from baseline MAC (1.51 ± 0.21%). Conclusions and clinical relevance: Fentanyl patches are placed to provide long-lasting analgesia. In order to be effective postoperatively, fentanyl patches must be placed prior to surgery. Plasma fentanyl concentrations achieved intraoperatively decrease the need for potent inhalant anesthetics in cats.
AB - Objective: To determine the effect of two doses of fentanyl, administered transdermally, on the minimum alveolar concentration (MAC) of isoflurane in cats. Study design: Prospective, randomized study. Animals: Five healthy, spayed, female cats. Methods: Each cat was studied thrice with at least 2 weeks between each study. In study 1, the baseline isoflurane MAC was determined in triplicate for each cat. In studies 2 and 3, isoflurane MAC was determined 24 hours after placement of either a 25 or 50 μg hour-1 fentanyl patch. In each MAC study, cats were instrumented to allow collection of arterial blood and measurement of arterial blood pressure. Twenty-four hours prior to studies 2 and 3, a catheter was placed and secured in the jugular vein and either a 25 or 50 μg hour-1 fentanyl patch was placed in random order on the left thorax. Blood samples for plasma fentanyl determination were collected prior to patch placement and at regular intervals up to 144 hours. After determination of MAC in studies 2 and 3, naloxone was administered as a bolus dose (0.1 mg kg-1) followed by an infusion (1 mg kg -1 hour-1) and MAC redetermined. Results: The baseline isoflurane MAC was 1.51 ± 0.21% (mean ± SD). Fentanyl (25 and 50 μg hour-1) administered transdermally significantly reduced MAC to 1.25 ± 0.26 and 1.22 ± 0.16%, respectively. These MAC reductions were not significantly different from each other. Isoflurane MAC determined during administration of fentanyl 25 μg hour-1 and naloxone (1.44 ± 0.16%) and fentanyl 50 μg hour-1 and naloxone (1.51 ± 0.19%) was not significantly different from baseline MAC (1.51 ± 0.21%). Conclusions and clinical relevance: Fentanyl patches are placed to provide long-lasting analgesia. In order to be effective postoperatively, fentanyl patches must be placed prior to surgery. Plasma fentanyl concentrations achieved intraoperatively decrease the need for potent inhalant anesthetics in cats.
KW - Cats
KW - Isoflurane
KW - MAC reduction (minimum alveolar concentration)
KW - Transdermal fentanyl
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UR - http://www.scopus.com/inward/citedby.url?scp=4944259858&partnerID=8YFLogxK
U2 - 10.1111/j.1467-2987.2004.00125.x
DO - 10.1111/j.1467-2987.2004.00125.x
M3 - Article
C2 - 15268689
AN - SCOPUS:4944259858
VL - 31
SP - 183
EP - 189
JO - Veterinary Anaesthesia and Analgesia
JF - Veterinary Anaesthesia and Analgesia
SN - 1467-2987
IS - 3
ER -