Effect of time on measurement of hepatic glucose production

Y. D I Chen, Arthur L Swislocki, C. Y. Jeng, J. H. Juang, G. M. Reaven

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Basal hepatic glucose production (HGP) was determined in obese and nonobese normal subjects and patients with noninsulin-dependent diabetes mellitus (NIDDM) using [3-3H]glucose and the nonsteady state equations of Steele. When HGP was estimated at hourly intervals from 0800-1300 h, it became evident that calculated values for HGP fell for the first 2-4 h until a plateau was reached, and this decline was quite precipitous during the first 2 h in patients with NIDDM. Furthermore, when the same patient with NIDDM was studied on two occasions, similar values for HGP were not uniformly obtained unless measurements were made at least 4 h after [3-3H]glucose administration. Since it has been the convention to use the nonsteady state equations of Steele to calculate HGP in patients with NIDDM 2 h after [3-3H]glucose administration, it is almost certain that published values for HGP in patients with NIDDM are falsely high. Based upon the data presented, we suggest that HGP using [3-3H]glucose and the nonsteady state Steele equations be measured for at least a 4-h period in patients with NIDDM in order to increase the validity of the calculated value.

Original languageEnglish (US)
Pages (from-to)1084-1088
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume67
Issue number5
StatePublished - 1988
Externally publishedYes

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Glucose
Liver
Medical problems
Type 2 Diabetes Mellitus
Equations of state

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Chen, Y. D. I., Swislocki, A. L., Jeng, C. Y., Juang, J. H., & Reaven, G. M. (1988). Effect of time on measurement of hepatic glucose production. Journal of Clinical Endocrinology and Metabolism, 67(5), 1084-1088.

Effect of time on measurement of hepatic glucose production. / Chen, Y. D I; Swislocki, Arthur L; Jeng, C. Y.; Juang, J. H.; Reaven, G. M.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 67, No. 5, 1988, p. 1084-1088.

Research output: Contribution to journalArticle

Chen, YDI, Swislocki, AL, Jeng, CY, Juang, JH & Reaven, GM 1988, 'Effect of time on measurement of hepatic glucose production', Journal of Clinical Endocrinology and Metabolism, vol. 67, no. 5, pp. 1084-1088.
Chen, Y. D I ; Swislocki, Arthur L ; Jeng, C. Y. ; Juang, J. H. ; Reaven, G. M. / Effect of time on measurement of hepatic glucose production. In: Journal of Clinical Endocrinology and Metabolism. 1988 ; Vol. 67, No. 5. pp. 1084-1088.
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