Effect of supranormal coronary blood flow on energy metabolism and systolic function of porcine left ventricle

Gregory G. Schwartz, Saul Schaefer, Steven D. Trocha, Jorge Garcia, Scan Steinman, Barry M. Massie, Michael W. Weiner

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Objective: The goal was to determine if supranormal coronary blood flow increases myocardial oxygen consumption, high energy phosphate levels, and systolic function in the in situ autoperfused heart. Methods: Thirteen anaesthetised open chest pigs with an intact, autoperfused coronary circulation, weight 30-40 kg, were studied. Measurements were made under basal conditions and during regional hyperperfusion of the anterior left ventricle produced by intracoronary infusion of adenosine (mean dose 3.3 (μmol·min-1). Doppler coronary blood flow velocity in the anterior descending coronary artery, arterial and anterior interventricular venous blood oxygen content, high energy phosphates (by transmurally localised 31P NMR), and myocardial wall thickening (by sonomicrometry) were measured. Results: With adenosine, coronary flow was increased to 355(SEM 59)% of control. Supranormal coronary flow produced no significant changes in anterior left ventricular oxygen consumption [99(12)% of control]. 31P NMR spectroscopy revealed no significant changes in the peak intensities of phosphocreatine or ATP in either the subendocardium or subepicardium (90-97% of control). Systolic anterior left ventricular wall thickening also did not change [107(13)% of control]. Conclusions: Supranormal coronary flow does not augment myocardial oxygen consumption, high energy phosphates, or systolic function in the in situ autoperfused heart. Myocardial oxygen delivery does not limit oxidative metabolism under normal conditions.

Original languageEnglish (US)
Pages (from-to)1001-1006
Number of pages6
JournalCardiovascular Research
Volume26
Issue number10
StatePublished - 1992

Keywords

  • Coronary circulation
  • Coronary hyperperfusion
  • Energy metabolism
  • Garden hose effect
  • Gregg Phenomenon
  • Myocardial contraction
  • Nuclear magnetic resonance
  • Oxygen consumption

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology

Fingerprint Dive into the research topics of 'Effect of supranormal coronary blood flow on energy metabolism and systolic function of porcine left ventricle'. Together they form a unique fingerprint.

  • Cite this

    Schwartz, G. G., Schaefer, S., Trocha, S. D., Garcia, J., Steinman, S., Massie, B. M., & Weiner, M. W. (1992). Effect of supranormal coronary blood flow on energy metabolism and systolic function of porcine left ventricle. Cardiovascular Research, 26(10), 1001-1006.