Abstract
The action of serum from cystic fibrosis patients, obligatory heterozygotes, siblings, and normal patients on mucin secretion from dispersed rat submandibular cells was investigated in an attempt to demonstrate the existence of cystic fibrosis specific factors affecting mucin secretion. No effects specific to cystic fibrosis serum were demonstrated using the following parameters for evaluation: (1) maximal stimulation of mucin release by a β-adrenergic agonist, (-)-isoproterenol; (2) basal release (unstimulated secretion) of mucin material; and (3) the dose-receptor relationship for mucin release after β-adrenergic receptor stimulation. No differences were observed in mucin secretion using media concentrations of serum of up to 10%. From these data, we conclude that serum from individuals with cystic fibrosis does not contain bioactive factors at concentrations that specifically alter mucin secretion in rat submandibular acinar cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 899-902 |
| Number of pages | 4 |
| Journal | Pediatric Research |
| Volume | 17 |
| Issue number | 11 |
| State | Published - 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
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Effect of serum from normal and cystic fibrosis subjects on mucin secretion from dispersed rat submandibular cells. / Quissell, D. O.; McDonald, Ruth J; Barzen, K. A.; Deisher, L. M.
In: Pediatric Research, Vol. 17, No. 11, 1983, p. 899-902.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of serum from normal and cystic fibrosis subjects on mucin secretion from dispersed rat submandibular cells
AU - Quissell, D. O.
AU - McDonald, Ruth J
AU - Barzen, K. A.
AU - Deisher, L. M.
PY - 1983
Y1 - 1983
N2 - The action of serum from cystic fibrosis patients, obligatory heterozygotes, siblings, and normal patients on mucin secretion from dispersed rat submandibular cells was investigated in an attempt to demonstrate the existence of cystic fibrosis specific factors affecting mucin secretion. No effects specific to cystic fibrosis serum were demonstrated using the following parameters for evaluation: (1) maximal stimulation of mucin release by a β-adrenergic agonist, (-)-isoproterenol; (2) basal release (unstimulated secretion) of mucin material; and (3) the dose-receptor relationship for mucin release after β-adrenergic receptor stimulation. No differences were observed in mucin secretion using media concentrations of serum of up to 10%. From these data, we conclude that serum from individuals with cystic fibrosis does not contain bioactive factors at concentrations that specifically alter mucin secretion in rat submandibular acinar cells.
AB - The action of serum from cystic fibrosis patients, obligatory heterozygotes, siblings, and normal patients on mucin secretion from dispersed rat submandibular cells was investigated in an attempt to demonstrate the existence of cystic fibrosis specific factors affecting mucin secretion. No effects specific to cystic fibrosis serum were demonstrated using the following parameters for evaluation: (1) maximal stimulation of mucin release by a β-adrenergic agonist, (-)-isoproterenol; (2) basal release (unstimulated secretion) of mucin material; and (3) the dose-receptor relationship for mucin release after β-adrenergic receptor stimulation. No differences were observed in mucin secretion using media concentrations of serum of up to 10%. From these data, we conclude that serum from individuals with cystic fibrosis does not contain bioactive factors at concentrations that specifically alter mucin secretion in rat submandibular acinar cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021030324&partnerID=8YFLogxK
M3 - Article
C2 - 6646901
AN - SCOPUS:0021030324
VL - 17
SP - 899
EP - 902
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
IS - 11
ER -