Abstract
Objective: To investigate the effect of rhTNFR: Fc on proliferation and cytokines production of synoviocytes from adjuvant arthritis (AA) rats. Methods: AA rats were induced by complete Freund adjuvant. The proliferation of synoviocytes was detected by 3H-TdR. The levels of IL-1β, IL-6, IL-17, LTα, RANKL and MMP-13 in supernate of synoviocytes were assessed by ELISA. Results: Administration of rhTNFR: Fc significantly inhibited the proliferation of synoviocytes and decreased the secretion of IL-1β, IL-6, IL-17, LTα, RANKL and MMP-13. Conclusions: Our results indicate that rhTNFR: Fc significantly reduces the proliferation and proinflammatory cytokines production of synoviocytes, which might be one of the therapeutic mechanisms for rhTNFR: Fc in AA.
Original language | English (US) |
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Pages (from-to) | 1166-1169 |
Number of pages | 4 |
Journal | Chinese Journal of New Drugs |
Volume | 22 |
Issue number | 10 |
State | Published - May 30 2013 |
Externally published | Yes |
Keywords
- Adjuvant arthritis
- RhTNFR: Fc
- Synoviocyte
- TNF-α
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)