Effect of rhTNFR: Fc on synoviocytes from rats with adjuvant arthritis

Jing Yu Chen; Hua Xun Wu; Yu Jing Wu; Ling Ling Zhang; Qingtong Wang; Shan Shan Song; Bei Huang; Pei Pei Li; Wei Wei

Effect of rhTNFR: Fc on synoviocytes from rats with adjuvant arthritis

Jing Yu Chen, Hua Xun Wu, Yu Jing Wu, Ling Ling Zhang, Qingtong Wang, Shan Shan Song, Bei Huang, Pei Pei Li, Wei Wei

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To investigate the effect of rhTNFR: Fc on proliferation and cytokines production of synoviocytes from adjuvant arthritis (AA) rats. Methods: AA rats were induced by complete Freund adjuvant. The proliferation of synoviocytes was detected by ³H-TdR. The levels of IL-1β, IL-6, IL-17, LTα, RANKL and MMP-13 in supernate of synoviocytes were assessed by ELISA. Results: Administration of rhTNFR: Fc significantly inhibited the proliferation of synoviocytes and decreased the secretion of IL-1β, IL-6, IL-17, LTα, RANKL and MMP-13. Conclusions: Our results indicate that rhTNFR: Fc significantly reduces the proliferation and proinflammatory cytokines production of synoviocytes, which might be one of the therapeutic mechanisms for rhTNFR: Fc in AA.

Original language	English (US)
Pages (from-to)	1166-1169
Number of pages	4
Journal	Chinese Journal of New Drugs
Volume	22
Issue number	10
State	Published - May 30 2013
Externally published	Yes

Keywords

Adjuvant arthritis
RhTNFR: Fc
Synoviocyte
TNF-α

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology, Toxicology and Pharmaceutics(all)

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@article{590954e1d5ed49b091a6c85b5e1b3007,

title = "Effect of rhTNFR: Fc on synoviocytes from rats with adjuvant arthritis",

abstract = "Objective: To investigate the effect of rhTNFR: Fc on proliferation and cytokines production of synoviocytes from adjuvant arthritis (AA) rats. Methods: AA rats were induced by complete Freund adjuvant. The proliferation of synoviocytes was detected by 3H-TdR. The levels of IL-1β, IL-6, IL-17, LTα, RANKL and MMP-13 in supernate of synoviocytes were assessed by ELISA. Results: Administration of rhTNFR: Fc significantly inhibited the proliferation of synoviocytes and decreased the secretion of IL-1β, IL-6, IL-17, LTα, RANKL and MMP-13. Conclusions: Our results indicate that rhTNFR: Fc significantly reduces the proliferation and proinflammatory cytokines production of synoviocytes, which might be one of the therapeutic mechanisms for rhTNFR: Fc in AA.",

keywords = "Adjuvant arthritis, RhTNFR: Fc, Synoviocyte, TNF-α",

author = "Chen, {Jing Yu} and Wu, {Hua Xun} and Wu, {Yu Jing} and Zhang, {Ling Ling} and Qingtong Wang and Song, {Shan Shan} and Bei Huang and Li, {Pei Pei} and Wei Wei",

year = "2013",

month = may,

day = "30",

language = "English (US)",

volume = "22",

pages = "1166--1169",

journal = "Chinese Journal of New Drugs",

issn = "1003-3734",

publisher = "Chinese Journal of New Drugs Co. Ltd.",

number = "10",

}

TY - JOUR

T1 - Effect of rhTNFR

T2 - Fc on synoviocytes from rats with adjuvant arthritis

AU - Chen, Jing Yu

AU - Wu, Hua Xun

AU - Wu, Yu Jing

AU - Zhang, Ling Ling

AU - Wang, Qingtong

AU - Song, Shan Shan

AU - Huang, Bei

AU - Li, Pei Pei

AU - Wei, Wei

PY - 2013/5/30

Y1 - 2013/5/30

N2 - Objective: To investigate the effect of rhTNFR: Fc on proliferation and cytokines production of synoviocytes from adjuvant arthritis (AA) rats. Methods: AA rats were induced by complete Freund adjuvant. The proliferation of synoviocytes was detected by 3H-TdR. The levels of IL-1β, IL-6, IL-17, LTα, RANKL and MMP-13 in supernate of synoviocytes were assessed by ELISA. Results: Administration of rhTNFR: Fc significantly inhibited the proliferation of synoviocytes and decreased the secretion of IL-1β, IL-6, IL-17, LTα, RANKL and MMP-13. Conclusions: Our results indicate that rhTNFR: Fc significantly reduces the proliferation and proinflammatory cytokines production of synoviocytes, which might be one of the therapeutic mechanisms for rhTNFR: Fc in AA.

AB - Objective: To investigate the effect of rhTNFR: Fc on proliferation and cytokines production of synoviocytes from adjuvant arthritis (AA) rats. Methods: AA rats were induced by complete Freund adjuvant. The proliferation of synoviocytes was detected by 3H-TdR. The levels of IL-1β, IL-6, IL-17, LTα, RANKL and MMP-13 in supernate of synoviocytes were assessed by ELISA. Results: Administration of rhTNFR: Fc significantly inhibited the proliferation of synoviocytes and decreased the secretion of IL-1β, IL-6, IL-17, LTα, RANKL and MMP-13. Conclusions: Our results indicate that rhTNFR: Fc significantly reduces the proliferation and proinflammatory cytokines production of synoviocytes, which might be one of the therapeutic mechanisms for rhTNFR: Fc in AA.

KW - Adjuvant arthritis

KW - RhTNFR: Fc

KW - Synoviocyte

KW - TNF-α

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M3 - Article

AN - SCOPUS:84881291006

VL - 22

SP - 1166

EP - 1169

JO - Chinese Journal of New Drugs

JF - Chinese Journal of New Drugs

SN - 1003-3734

IS - 10

ER -