Effect of rhTNFR: Fc on synoviocytes from rats with adjuvant arthritis

Jing Yu Chen, Hua Xun Wu, Yu Jing Wu, Ling Ling Zhang, Qingtong Wang, Shan Shan Song, Bei Huang, Pei Pei Li, Wei Wei

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the effect of rhTNFR: Fc on proliferation and cytokines production of synoviocytes from adjuvant arthritis (AA) rats. Methods: AA rats were induced by complete Freund adjuvant. The proliferation of synoviocytes was detected by 3H-TdR. The levels of IL-1β, IL-6, IL-17, LTα, RANKL and MMP-13 in supernate of synoviocytes were assessed by ELISA. Results: Administration of rhTNFR: Fc significantly inhibited the proliferation of synoviocytes and decreased the secretion of IL-1β, IL-6, IL-17, LTα, RANKL and MMP-13. Conclusions: Our results indicate that rhTNFR: Fc significantly reduces the proliferation and proinflammatory cytokines production of synoviocytes, which might be one of the therapeutic mechanisms for rhTNFR: Fc in AA.

Original languageEnglish (US)
Pages (from-to)1166-1169
Number of pages4
JournalChinese Journal of New Drugs
Volume22
Issue number10
StatePublished - May 30 2013
Externally publishedYes

Keywords

  • Adjuvant arthritis
  • RhTNFR: Fc
  • Synoviocyte
  • TNF-α

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Chen, J. Y., Wu, H. X., Wu, Y. J., Zhang, L. L., Wang, Q., Song, S. S., Huang, B., Li, P. P., & Wei, W. (2013). Effect of rhTNFR: Fc on synoviocytes from rats with adjuvant arthritis. Chinese Journal of New Drugs, 22(10), 1166-1169.