Effect of reducing the nicotine content of cigarettes on cigarette smoking behavior and tobacco smoke toxicant exposure: 2-year follow up

Neal L. Benowitz, Natalie Nardone, Katherine M. Dains, Sharon M. Hall, Susan L Stewart, Delia Dempsey, Peyton Jacob

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Background and Aims: A broadly mandated reduction of the nicotine content (RNC) of cigarettes has been proposed in the United States to reduce the addictiveness of cigarettes, to prevent new smokers from becoming addicted and to facilitate quitting in established smokers. The primary aim of this study was to determine whether following 7months of smoking very low nicotine content cigarettes (VLNC), and then returning to their own cigarettes, smokers would demonstrate persistently reduced nicotine intake compared with baseline or quit smoking. Methods: In a community-based clinic 135 smokers not interested in quitting were randomized to one of two groups. A research group smoked their usual brand of cigarettes, followed by five types of research cigarettes with progressively lower nicotine content, each for 1month, followed by 6months at the lowest nicotine level (0.5mg/cigarette) (53 subjects) and then 12months with no intervention (30 subjects completed). A control group smoked their usual brand for the same period of time (50subjects at 6months, 38 completed). Smoking behavior, biomarkers of nicotine intake and smoke toxicant exposure were measured. Results: After 7 months smoking VLNC, nicotine intake remained below baseline (plasma cotinine 149 versus 250ng/ml, P

Original languageEnglish (US)
Pages (from-to)1667-1675
Number of pages9
JournalAddiction
Volume110
Issue number10
DOIs
StatePublished - Oct 1 2015

Keywords

  • Addiction
  • Biomarkers
  • Cigarette smoking
  • Cotinine
  • Drug dependence
  • Nicotine
  • Reduction

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health

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