Effect of random and scatter fractions in variance reduction using time-of-flight information

Joey A. Kimdon, Jinyi Qi, William W. Moses

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Scopus citations

Abstract

The ability of differential time-of-flight (TOF) information to reduce the statistical noise variance in PET reconstructions has been known since the 1980's. Since then, the technology and applications of PET have evolved, warranting a reconsideration of the estimated improvements of TOF with respect to modern PET. For example, whereas 2D cardiology or neurology studies were once the only options, 3D clinical whole-body oncology imaging is becoming more common. The augmented sensitivity, change in object size and shape, as well as the accompanying changes in isotope and dose, result in different relative amounts of scattered, random, and true coincidences than were seen in the past. Thus in an analysis of the TOF gain for modern PET, it is useful to consider the separate effects of varying these fractions. We present a simulation study investigating the relative amount of TOF contrast-to-noise gain for a range of levels of scattered and random coincidences. We demonstrate that both increased scatter and increased randoms noticeably enhance the TOF gain, but that the higher randoms fraction introduces the most drastic improvement. These results are encouraging for modern PET, where there is a greater random/scatter fraction than in the PET of the 1980's.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium Conference Record
EditorsS.D. Metzler
Pages2571-2573
Number of pages3
Volume4
StatePublished - 2003
Externally publishedYes
Event2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference - Portland, OR, United States
Duration: Oct 19 2003Oct 25 2003

Other

Other2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference
CountryUnited States
CityPortland, OR
Period10/19/0310/25/03

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Keywords

  • CNR
  • LaBr
  • LSO
  • Positron emission tomography
  • Random coincidences
  • Scattered events
  • Time-of-flight

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Industrial and Manufacturing Engineering

Cite this

Kimdon, J. A., Qi, J., & Moses, W. W. (2003). Effect of random and scatter fractions in variance reduction using time-of-flight information. In S. D. Metzler (Ed.), IEEE Nuclear Science Symposium Conference Record (Vol. 4, pp. 2571-2573). [M10-199]