Abstract
In these experiments we define an effective means of pulsed magnetic stimulation of the facial nerve for the purpose of increasing cerebral blood flow (CBF). In normal anesthetized dog and sheep, a focal magnetic field was directed toward the facial nerve within the temporal bone by placing a 6.5 cm figure-8 stimulation coil over the ear. In an initial set of experiments, CBF was measured by laser Doppler flowmetry and the cerebral vasculature was visualized by angiography. The effect of facial nerve stimulation was found to be dependent on stimulation power, frequency, and the precise positioning of the stimulation coil. Furthermore, an increase in CBF was not observed after direct electrical stimulation in the middle ear space, indicating that non-specific stimulation of the tympanic plexus, an intervening neural structure with vasoactive effects, was not responsible for the increase in CBF after pulsed magnetic stimulation. Subsequent experiments using perfusion MRI demonstrated reproducible increases in CBF throughout the forebrain that manifested bilaterally, albeit with an ipsilateral predominance. These experiments support the development of a non-invasive pulsed magnetic facial nerve stimulator that will increase CBF as a treatment of ischemic stroke.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 58-67 |
| Number of pages | 10 |
| Journal | Brain Research |
| Volume | 1528 |
| DOIs | |
| State | Published - Aug 28 2013 |
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Keywords
- Cerebral blood flow
- Facial nerve
- Magnetic stimulation
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
- Developmental Biology
- Molecular Biology
- Medicine(all)
Cite this
Effect of pulsed magnetic stimulation of the facial nerve on cerebral blood flow. / Borsody, Mark K.; Yamada, Chisa; Bielawski, Dawn; Heaton, Tamara; Lyeth, Bruce G; Garcia, Andrea; Castro Prado, Fernando; Azpiroz, Joaquín; Sacristan, Emilio.
In: Brain Research, Vol. 1528, 28.08.2013, p. 58-67.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of pulsed magnetic stimulation of the facial nerve on cerebral blood flow
AU - Borsody, Mark K.
AU - Yamada, Chisa
AU - Bielawski, Dawn
AU - Heaton, Tamara
AU - Lyeth, Bruce G
AU - Garcia, Andrea
AU - Castro Prado, Fernando
AU - Azpiroz, Joaquín
AU - Sacristan, Emilio
PY - 2013/8/28
Y1 - 2013/8/28
N2 - In these experiments we define an effective means of pulsed magnetic stimulation of the facial nerve for the purpose of increasing cerebral blood flow (CBF). In normal anesthetized dog and sheep, a focal magnetic field was directed toward the facial nerve within the temporal bone by placing a 6.5 cm figure-8 stimulation coil over the ear. In an initial set of experiments, CBF was measured by laser Doppler flowmetry and the cerebral vasculature was visualized by angiography. The effect of facial nerve stimulation was found to be dependent on stimulation power, frequency, and the precise positioning of the stimulation coil. Furthermore, an increase in CBF was not observed after direct electrical stimulation in the middle ear space, indicating that non-specific stimulation of the tympanic plexus, an intervening neural structure with vasoactive effects, was not responsible for the increase in CBF after pulsed magnetic stimulation. Subsequent experiments using perfusion MRI demonstrated reproducible increases in CBF throughout the forebrain that manifested bilaterally, albeit with an ipsilateral predominance. These experiments support the development of a non-invasive pulsed magnetic facial nerve stimulator that will increase CBF as a treatment of ischemic stroke.
AB - In these experiments we define an effective means of pulsed magnetic stimulation of the facial nerve for the purpose of increasing cerebral blood flow (CBF). In normal anesthetized dog and sheep, a focal magnetic field was directed toward the facial nerve within the temporal bone by placing a 6.5 cm figure-8 stimulation coil over the ear. In an initial set of experiments, CBF was measured by laser Doppler flowmetry and the cerebral vasculature was visualized by angiography. The effect of facial nerve stimulation was found to be dependent on stimulation power, frequency, and the precise positioning of the stimulation coil. Furthermore, an increase in CBF was not observed after direct electrical stimulation in the middle ear space, indicating that non-specific stimulation of the tympanic plexus, an intervening neural structure with vasoactive effects, was not responsible for the increase in CBF after pulsed magnetic stimulation. Subsequent experiments using perfusion MRI demonstrated reproducible increases in CBF throughout the forebrain that manifested bilaterally, albeit with an ipsilateral predominance. These experiments support the development of a non-invasive pulsed magnetic facial nerve stimulator that will increase CBF as a treatment of ischemic stroke.
KW - Cerebral blood flow
KW - Facial nerve
KW - Magnetic stimulation
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UR - http://www.scopus.com/inward/citedby.url?scp=84882251085&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2013.06.022
DO - 10.1016/j.brainres.2013.06.022
M3 - Article
C2 - 23850647
AN - SCOPUS:84882251085
VL - 1528
SP - 58
EP - 67
JO - Brain Research
JF - Brain Research
SN - 0006-8993
ER -