Effect of proteasome inhibitor 1 on wound healing: A potential scar prevention therapy

John A. Walker, Gianni Rossini, Michelle W. Thompson, Joseph C. Wenke, David Baer, Matthew Q. Pompeo, Bobby Dezfuli, Chin-Shang Li, J Nilas Young, Michael S Wong, John F. Tarlton, Hugh S. Munro

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

In vitro and in vivo assessments suggest that proteasome inhibitors may be useful for modulating wound healing. Methods. Proteasome Inhibitor I was used to assess the potential utility of proteasome inhibitors in improving wound healing in a standard rat model. Bilateral, 6 cm incisions were made 1 cm lateral to the spine of adult male Sprague Dawley rats. Animals were randomly assigned to 1 of 3 groups: no treatment (n ≤ 15), low concentration (1% w/v, n ≤ 15), or high concentration (5% w/v, n ≤ 15). Treatments were applied to the left side incision at 0 hours, 24 hours, and 48 hours. Right-side incisionsreceived a vehicle, dimethyl sulfoxide, alone and independent of the assigned group, serving as both external and internal controls. Rats were sacrificed at days 7, 14, and 28 (n ≤ 5 per group) and wounds subjected to mechanical testing and histology. Results. No significant intergroup difference existed at 7 and 14 days. On day 28, a dosedependent increase in tensile strength with increasing Proteasome Inhibitor I was observed. Conclusion. Results suggest dimethyl sulfoxide was not the ideal vehicle and additional improvement may be realized by optimizing the delivery method.

Original languageEnglish (US)
Pages (from-to)28-33
Number of pages6
JournalWounds
Volume25
Issue number2
StatePublished - Feb 2013

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical

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    Walker, J. A., Rossini, G., Thompson, M. W., Wenke, J. C., Baer, D., Pompeo, M. Q., Dezfuli, B., Li, C-S., Young, J. N., Wong, M. S., Tarlton, J. F., & Munro, H. S. (2013). Effect of proteasome inhibitor 1 on wound healing: A potential scar prevention therapy. Wounds, 25(2), 28-33.