Effect of prostaglandin blockers on ascites fluid in pancreatitis

L. R. Farias, C. F. Frey, James W Holcroft, R. Gunther

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Prostacyclin (PGI2), a potent vasodilator with complex effects on the mesenteric circulation, has been found to be elevated in the hemorrhagic ascitic fluid of pigs with hemorrhagic pancreatitis. This investigation was designed to determine if blockage of PGI2 significantly reduces the volume and/or toxicity of hemorrhagic ascitic fluid associated with hemorrhagic pancreatitis in pigs. Fifteen pigs were studied: five received corticosteroids, five received ibuprofen, and five were untreated. The relative toxicity of the hemorrhagic ascitic fluid was assessed by intraperitoneal injections of the fluid from pigs into mice. Results: (1) hemorrhagic pancreatitis was associated with high levels of PGI2 in blood 15 times and in hemorrhagic ascitic acid fluid 25 times that of baseline; (2) steroids and ibuprofen blocked PGI2 production (p<0.05); (3) neither steroids nor ibuprofen, even when administered as pretreatment, decreased ascites formation; and (4) the mortality rate in mice was significantly reduced (p<0.05) in the ibuprofen-treated group as compared with the untreated and steroid-treated groups. Conclusion: PGI2 does not play a significant role in the volume of ascites formation. There was an absence of toxicity in the hemorrhagic ascitic fluid of the ibuprofen-treated group.

Original languageEnglish (US)
Pages (from-to)571-578
Number of pages8
JournalSurgery
Volume98
Issue number3
StatePublished - 1985

ASJC Scopus subject areas

  • Surgery

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    Farias, L. R., Frey, C. F., Holcroft, J. W., & Gunther, R. (1985). Effect of prostaglandin blockers on ascites fluid in pancreatitis. Surgery, 98(3), 571-578.