TY - JOUR
T1 - Effect of Prebiotic Supplementation and Calcium Intake on Body Mass Index
AU - Abrams, Steven A.
AU - Griffin, Ian J.
AU - Hawthorne, Keli M.
AU - Ellis, Kenneth J.
PY - 2007/9
Y1 - 2007/9
N2 - Objective: To assess the effects of a prebiotic supplement and usual calcium intake on body composition changes during pubertal growth. Study design: We measured anthropometry and body fat with dual-energy X-ray absorptiometry in 97 young adolescents who were randomized to receive either a daily prebiotic supplement or maltodextrin (control) for 1 year. Results: Subjects who received the prebiotic supplement had a smaller increase in body mass index (BMI) compared with the control group (BMI difference 0.52 ± 0.16 kg/m2, P = .016), BMI Z-score (difference 0.13 ± 0.06, P = .048) and total fat mass (difference 0.84 ± 0.36 kg, P = .022). The prebiotic group maintained their baseline BMI Z-score (0.03 ± 0.01, paired t test, P = .30), although BMI Z-score increased significantly in the control group (0.13 ± 0.03, P < .001). In considering subjects whose usual calcium intake was ≥700 mg/d, those who received the prebiotic supplement had a relative change in BMI that was 0.82 kg/m2 less than control subjects (P < .01), and BMI Z-score that was 0.20 less than control subjects (P = .003). Differences tended to be maintained 1 year after supplementation was stopped. Conclusion: Prebiotic supplementation and avoidance of a low calcium intake can have significant effects in modulating BMI and other body composition changes during puberty.
AB - Objective: To assess the effects of a prebiotic supplement and usual calcium intake on body composition changes during pubertal growth. Study design: We measured anthropometry and body fat with dual-energy X-ray absorptiometry in 97 young adolescents who were randomized to receive either a daily prebiotic supplement or maltodextrin (control) for 1 year. Results: Subjects who received the prebiotic supplement had a smaller increase in body mass index (BMI) compared with the control group (BMI difference 0.52 ± 0.16 kg/m2, P = .016), BMI Z-score (difference 0.13 ± 0.06, P = .048) and total fat mass (difference 0.84 ± 0.36 kg, P = .022). The prebiotic group maintained their baseline BMI Z-score (0.03 ± 0.01, paired t test, P = .30), although BMI Z-score increased significantly in the control group (0.13 ± 0.03, P < .001). In considering subjects whose usual calcium intake was ≥700 mg/d, those who received the prebiotic supplement had a relative change in BMI that was 0.82 kg/m2 less than control subjects (P < .01), and BMI Z-score that was 0.20 less than control subjects (P = .003). Differences tended to be maintained 1 year after supplementation was stopped. Conclusion: Prebiotic supplementation and avoidance of a low calcium intake can have significant effects in modulating BMI and other body composition changes during puberty.
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U2 - 10.1016/j.jpeds.2007.03.043
DO - 10.1016/j.jpeds.2007.03.043
M3 - Article
C2 - 17719942
AN - SCOPUS:34548140139
VL - 151
SP - 293
EP - 298
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 3
ER -