Effect of particle diameter and surface composition on the spontaneous fusion of monolayer-protected gold nanoparticles with lipid bilayers

Reid C. Van Lehn; Prabhani U. Atukorale; Randy Carney; Yu Sang Yang; Francesco Stellacci; Darrell J. Irvine; Alfredo Alexander-Katz

doi:10.1021/nl401365n

Effect of particle diameter and surface composition on the spontaneous fusion of monolayer-protected gold nanoparticles with lipid bilayers

Reid C. Van Lehn, Prabhani U. Atukorale, Randy Carney, Yu Sang Yang, Francesco Stellacci, Darrell J. Irvine, Alfredo Alexander-Katz

Research output: Contribution to journal › Article › peer-review

185 Scopus citations

Abstract

Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free energy calculations, experiments on unilamellar and multilamellar vesicles, and cell studies all support this hypothesis. Furthermore, we show that fusion is only favorable for AuNPs with core diameters below a critical size that depends on the monolayer composition.

Original language	English (US)
Pages (from-to)	4060-4067
Number of pages	8
Journal	Nano Letters
Volume	13
Issue number	9
DOIs	https://doi.org/10.1021/nl401365n
State	Published - Sep 11 2013
Externally published	Yes

Keywords

cell penetration
gold nanoparticle
lipid bilayer
membrane insertion
snorkeling
surface monolayer

ASJC Scopus subject areas

Bioengineering
Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl401365n

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Effect of particle diameter and surface composition on the spontaneous fusion of monolayer-protected gold nanoparticles with lipid bilayers. / Van Lehn, Reid C.; Atukorale, Prabhani U.; Carney, Randy; Yang, Yu Sang; Stellacci, Francesco; Irvine, Darrell J.; Alexander-Katz, Alfredo.

In: Nano Letters, Vol. 13, No. 9, 11.09.2013, p. 4060-4067.

Research output: Contribution to journal › Article › peer-review

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abstract = "Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free energy calculations, experiments on unilamellar and multilamellar vesicles, and cell studies all support this hypothesis. Furthermore, we show that fusion is only favorable for AuNPs with core diameters below a critical size that depends on the monolayer composition.",

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AU - Yang, Yu Sang

AU - Stellacci, Francesco

AU - Irvine, Darrell J.

AU - Alexander-Katz, Alfredo

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AB - Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free energy calculations, experiments on unilamellar and multilamellar vesicles, and cell studies all support this hypothesis. Furthermore, we show that fusion is only favorable for AuNPs with core diameters below a critical size that depends on the monolayer composition.

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KW - lipid bilayer

KW - membrane insertion

KW - snorkeling

KW - surface monolayer

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Effect of particle diameter and surface composition on the spontaneous fusion of monolayer-protected gold nanoparticles with lipid bilayers

Abstract

Keywords

ASJC Scopus subject areas

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