Abstract
Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free energy calculations, experiments on unilamellar and multilamellar vesicles, and cell studies all support this hypothesis. Furthermore, we show that fusion is only favorable for AuNPs with core diameters below a critical size that depends on the monolayer composition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4060-4067 |
| Number of pages | 8 |
| Journal | Nano Letters |
| Volume | 13 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 11 2013 |
| Externally published | Yes |
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Keywords
- cell penetration
- gold nanoparticle
- lipid bilayer
- membrane insertion
- snorkeling
- surface monolayer
ASJC Scopus subject areas
- Bioengineering
- Chemistry(all)
- Materials Science(all)
- Condensed Matter Physics
- Mechanical Engineering
Cite this
Effect of particle diameter and surface composition on the spontaneous fusion of monolayer-protected gold nanoparticles with lipid bilayers. / Van Lehn, Reid C.; Atukorale, Prabhani U.; Carney, Randy; Yang, Yu Sang; Stellacci, Francesco; Irvine, Darrell J.; Alexander-Katz, Alfredo.
In: Nano Letters, Vol. 13, No. 9, 11.09.2013, p. 4060-4067.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of particle diameter and surface composition on the spontaneous fusion of monolayer-protected gold nanoparticles with lipid bilayers
AU - Van Lehn, Reid C.
AU - Atukorale, Prabhani U.
AU - Carney, Randy
AU - Yang, Yu Sang
AU - Stellacci, Francesco
AU - Irvine, Darrell J.
AU - Alexander-Katz, Alfredo
PY - 2013/9/11
Y1 - 2013/9/11
N2 - Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free energy calculations, experiments on unilamellar and multilamellar vesicles, and cell studies all support this hypothesis. Furthermore, we show that fusion is only favorable for AuNPs with core diameters below a critical size that depends on the monolayer composition.
AB - Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free energy calculations, experiments on unilamellar and multilamellar vesicles, and cell studies all support this hypothesis. Furthermore, we show that fusion is only favorable for AuNPs with core diameters below a critical size that depends on the monolayer composition.
KW - cell penetration
KW - gold nanoparticle
KW - lipid bilayer
KW - membrane insertion
KW - snorkeling
KW - surface monolayer
UR - http://www.scopus.com/inward/record.url?scp=84884253530&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884253530&partnerID=8YFLogxK
U2 - 10.1021/nl401365n
DO - 10.1021/nl401365n
M3 - Article
C2 - 23915118
AN - SCOPUS:84884253530
VL - 13
SP - 4060
EP - 4067
JO - Nano Letters
JF - Nano Letters
SN - 1530-6984
IS - 9
ER -