Effect of oral magnesium supplementation on measures of airway resistance and subjective assessment of asthma control and quality of life in men and women with mild to moderate asthma: A randomized placebo controlled trial

Alexandra G. Kazaks, Janet Y. Uriu-Adams, Timothy E Albertson, Sonia F. Shenoy, Judith S. Stern

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Epidemiological data shows low dietary magnesium(Mg) may be related to incidence and progression of asthma. Objective To determine if long term(6.5 month) treatment with oral Mg would improve asthma control and increase serum measures of Mg status in men and women with mild-to-moderate asthma. Subjects: 55 males and females aged 21 to 55 years with mild to moderate asthma according to the 2002 National Heart, Lung, and Blood Institute(NHLBI) and Asthma Education and Prevention Program(NAEPP) guidelines and who used only beta-agonists or inhaled corticosteroids(ICS) as asthma medications were enrolled. Design: Subjects were randomly assigned to consume 340 mg(170 mg twice a day) of Mg or a placebo for 6.5 months. Measurements: Multiple measures of Mg status including serum, erythrocyte, urine, dietary, ionized and IV Mg were measured. Objective: markers of asthma control were: methacholine challenge test(MCCT) and pulmonary function test(PFT) results. Subjective validated questionnaires on asthma quality of life(AQLQ) and control(ACQ) were completed by participants. Markers of inflammation, including c-reactive protein(CRP) and exhaled nitric oxide(eNO) were determined. Results: The concentration of methacholine required to cause a 20% drop in forced expiratory volume in in minute(FEV1) increased significantly from baseline to month 6 within the Mg group. Peak expiratory flow rate(PEFR) showed a 5.8% predicted improvement over time(p=0.03) in those consuming the Mg. There was significant improvement in AQLQ mean score units(P < 0.01) and in overall ACQ score only in the Mg group(p=0.05) after 6.5 months of supplementation. Despite these improvements, there were no significant changes in any of the markers of Mg status. Conclusion: Adults who received oral Mg supplements showed improvement in objective measures of bronchial reactivity to methacholine and PEFR and in subjective measures of asthma control and quality of life.

Original languageEnglish (US)
Pages (from-to)83-92
Number of pages10
JournalJournal of Asthma
Volume47
Issue number1
DOIs
StatePublished - 2010

Fingerprint

Airway Resistance
Magnesium
Asthma
Randomized Controlled Trials
Placebos
Quality of Life
Methacholine Chloride
Peak Expiratory Flow Rate
National Heart, Lung, and Blood Institute (U.S.)
Respiratory Function Tests
Forced Expiratory Volume
Serum
Quality Control
Adrenal Cortex Hormones
Nitric Oxide
Erythrocytes
Urine
Guidelines
Inflammation

Keywords

  • Asthma
  • Asthma control
  • Dietary supplement
  • Magnesium
  • Methacholine
  • Quality of life

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health

Cite this

@article{c892e880dc67442095fa0f254a8cf62e,
title = "Effect of oral magnesium supplementation on measures of airway resistance and subjective assessment of asthma control and quality of life in men and women with mild to moderate asthma: A randomized placebo controlled trial",
abstract = "Background: Epidemiological data shows low dietary magnesium(Mg) may be related to incidence and progression of asthma. Objective To determine if long term(6.5 month) treatment with oral Mg would improve asthma control and increase serum measures of Mg status in men and women with mild-to-moderate asthma. Subjects: 55 males and females aged 21 to 55 years with mild to moderate asthma according to the 2002 National Heart, Lung, and Blood Institute(NHLBI) and Asthma Education and Prevention Program(NAEPP) guidelines and who used only beta-agonists or inhaled corticosteroids(ICS) as asthma medications were enrolled. Design: Subjects were randomly assigned to consume 340 mg(170 mg twice a day) of Mg or a placebo for 6.5 months. Measurements: Multiple measures of Mg status including serum, erythrocyte, urine, dietary, ionized and IV Mg were measured. Objective: markers of asthma control were: methacholine challenge test(MCCT) and pulmonary function test(PFT) results. Subjective validated questionnaires on asthma quality of life(AQLQ) and control(ACQ) were completed by participants. Markers of inflammation, including c-reactive protein(CRP) and exhaled nitric oxide(eNO) were determined. Results: The concentration of methacholine required to cause a 20{\%} drop in forced expiratory volume in in minute(FEV1) increased significantly from baseline to month 6 within the Mg group. Peak expiratory flow rate(PEFR) showed a 5.8{\%} predicted improvement over time(p=0.03) in those consuming the Mg. There was significant improvement in AQLQ mean score units(P < 0.01) and in overall ACQ score only in the Mg group(p=0.05) after 6.5 months of supplementation. Despite these improvements, there were no significant changes in any of the markers of Mg status. Conclusion: Adults who received oral Mg supplements showed improvement in objective measures of bronchial reactivity to methacholine and PEFR and in subjective measures of asthma control and quality of life.",
keywords = "Asthma, Asthma control, Dietary supplement, Magnesium, Methacholine, Quality of life",
author = "Kazaks, {Alexandra G.} and Uriu-Adams, {Janet Y.} and Albertson, {Timothy E} and Shenoy, {Sonia F.} and Stern, {Judith S.}",
year = "2010",
doi = "10.3109/02770900903331127",
language = "English (US)",
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T1 - Effect of oral magnesium supplementation on measures of airway resistance and subjective assessment of asthma control and quality of life in men and women with mild to moderate asthma

T2 - A randomized placebo controlled trial

AU - Kazaks, Alexandra G.

AU - Uriu-Adams, Janet Y.

AU - Albertson, Timothy E

AU - Shenoy, Sonia F.

AU - Stern, Judith S.

PY - 2010

Y1 - 2010

N2 - Background: Epidemiological data shows low dietary magnesium(Mg) may be related to incidence and progression of asthma. Objective To determine if long term(6.5 month) treatment with oral Mg would improve asthma control and increase serum measures of Mg status in men and women with mild-to-moderate asthma. Subjects: 55 males and females aged 21 to 55 years with mild to moderate asthma according to the 2002 National Heart, Lung, and Blood Institute(NHLBI) and Asthma Education and Prevention Program(NAEPP) guidelines and who used only beta-agonists or inhaled corticosteroids(ICS) as asthma medications were enrolled. Design: Subjects were randomly assigned to consume 340 mg(170 mg twice a day) of Mg or a placebo for 6.5 months. Measurements: Multiple measures of Mg status including serum, erythrocyte, urine, dietary, ionized and IV Mg were measured. Objective: markers of asthma control were: methacholine challenge test(MCCT) and pulmonary function test(PFT) results. Subjective validated questionnaires on asthma quality of life(AQLQ) and control(ACQ) were completed by participants. Markers of inflammation, including c-reactive protein(CRP) and exhaled nitric oxide(eNO) were determined. Results: The concentration of methacholine required to cause a 20% drop in forced expiratory volume in in minute(FEV1) increased significantly from baseline to month 6 within the Mg group. Peak expiratory flow rate(PEFR) showed a 5.8% predicted improvement over time(p=0.03) in those consuming the Mg. There was significant improvement in AQLQ mean score units(P < 0.01) and in overall ACQ score only in the Mg group(p=0.05) after 6.5 months of supplementation. Despite these improvements, there were no significant changes in any of the markers of Mg status. Conclusion: Adults who received oral Mg supplements showed improvement in objective measures of bronchial reactivity to methacholine and PEFR and in subjective measures of asthma control and quality of life.

AB - Background: Epidemiological data shows low dietary magnesium(Mg) may be related to incidence and progression of asthma. Objective To determine if long term(6.5 month) treatment with oral Mg would improve asthma control and increase serum measures of Mg status in men and women with mild-to-moderate asthma. Subjects: 55 males and females aged 21 to 55 years with mild to moderate asthma according to the 2002 National Heart, Lung, and Blood Institute(NHLBI) and Asthma Education and Prevention Program(NAEPP) guidelines and who used only beta-agonists or inhaled corticosteroids(ICS) as asthma medications were enrolled. Design: Subjects were randomly assigned to consume 340 mg(170 mg twice a day) of Mg or a placebo for 6.5 months. Measurements: Multiple measures of Mg status including serum, erythrocyte, urine, dietary, ionized and IV Mg were measured. Objective: markers of asthma control were: methacholine challenge test(MCCT) and pulmonary function test(PFT) results. Subjective validated questionnaires on asthma quality of life(AQLQ) and control(ACQ) were completed by participants. Markers of inflammation, including c-reactive protein(CRP) and exhaled nitric oxide(eNO) were determined. Results: The concentration of methacholine required to cause a 20% drop in forced expiratory volume in in minute(FEV1) increased significantly from baseline to month 6 within the Mg group. Peak expiratory flow rate(PEFR) showed a 5.8% predicted improvement over time(p=0.03) in those consuming the Mg. There was significant improvement in AQLQ mean score units(P < 0.01) and in overall ACQ score only in the Mg group(p=0.05) after 6.5 months of supplementation. Despite these improvements, there were no significant changes in any of the markers of Mg status. Conclusion: Adults who received oral Mg supplements showed improvement in objective measures of bronchial reactivity to methacholine and PEFR and in subjective measures of asthma control and quality of life.

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KW - Methacholine

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