Abstract
Objective: To identify whether nutrient supplementation with probiotics, prebiotics, formula, or fatty acids prevents the development of atopic dermatitis (AD) or reduces the severity of AD in newborns to children younger than 3 years. Data Sources: We searched MEDLINE, Cochrane Central Register of Controlled Trials, and LILACS (Latin American and Caribbean Health Science Literature) from January 1, 1946, to August 27, 2012, and performed an additional manual search. Study Selection: Randomized controlled trials and cohort studies examining nutritional supplementation in prevention and amelioration of AD among children younger than 3 years. Data Extraction: Of 92 articles, 21 met inclusion criteria. Data Synthesis: In the 21 studies, a total of 6859 participants received supplements, which included infants or mothers who were either pregnant or breastfeeding; 4134 infants or mothers served as controls. Nutritional supplementation was shown to be an effective method in preventing AD (11 of 17 studies) or decreasing its severity (5 of 6 studies). The best evidence lies with probiotics supplementation in mothers and infants in preventing development and reducing severity of AD. Specifically, Lactobacillus rhamnosus GG was effective in long-term prevention of AD development. γ-Linolenic acid reduced severity of AD. Supplementation with prebiotics and black currant seed oil (γ-linolenic acid and ω-3 combination) was effective in reducing the development of AD. Conflicting findings were reported from different research groups that performed supplementation with an amino acid-based formula. Conclusions: Certain types of nutrient supplementation are beneficial in preventing AD development and reducing its severity. Future research elucidating the mechanisms underlying the actions of nutritional supplementation on AD is necessary.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 350-355 |
| Number of pages | 6 |
| Journal | JAMA Dermatology |
| Volume | 149 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2013 |
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ASJC Scopus subject areas
- Dermatology
Cite this
Effect of nutrient supplementation on atopic dermatitis in children : A systematic review of probiotics, prebiotics, formula, and fatty acids. / Foolad, Negar; Brezinski, Elizabeth A.; Chase, Elizabeth P.; Armstrong, April W.
In: JAMA Dermatology, Vol. 149, No. 3, 03.2013, p. 350-355.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of nutrient supplementation on atopic dermatitis in children
T2 - A systematic review of probiotics, prebiotics, formula, and fatty acids
AU - Foolad, Negar
AU - Brezinski, Elizabeth A.
AU - Chase, Elizabeth P.
AU - Armstrong, April W.
PY - 2013/3
Y1 - 2013/3
N2 - Objective: To identify whether nutrient supplementation with probiotics, prebiotics, formula, or fatty acids prevents the development of atopic dermatitis (AD) or reduces the severity of AD in newborns to children younger than 3 years. Data Sources: We searched MEDLINE, Cochrane Central Register of Controlled Trials, and LILACS (Latin American and Caribbean Health Science Literature) from January 1, 1946, to August 27, 2012, and performed an additional manual search. Study Selection: Randomized controlled trials and cohort studies examining nutritional supplementation in prevention and amelioration of AD among children younger than 3 years. Data Extraction: Of 92 articles, 21 met inclusion criteria. Data Synthesis: In the 21 studies, a total of 6859 participants received supplements, which included infants or mothers who were either pregnant or breastfeeding; 4134 infants or mothers served as controls. Nutritional supplementation was shown to be an effective method in preventing AD (11 of 17 studies) or decreasing its severity (5 of 6 studies). The best evidence lies with probiotics supplementation in mothers and infants in preventing development and reducing severity of AD. Specifically, Lactobacillus rhamnosus GG was effective in long-term prevention of AD development. γ-Linolenic acid reduced severity of AD. Supplementation with prebiotics and black currant seed oil (γ-linolenic acid and ω-3 combination) was effective in reducing the development of AD. Conflicting findings were reported from different research groups that performed supplementation with an amino acid-based formula. Conclusions: Certain types of nutrient supplementation are beneficial in preventing AD development and reducing its severity. Future research elucidating the mechanisms underlying the actions of nutritional supplementation on AD is necessary.
AB - Objective: To identify whether nutrient supplementation with probiotics, prebiotics, formula, or fatty acids prevents the development of atopic dermatitis (AD) or reduces the severity of AD in newborns to children younger than 3 years. Data Sources: We searched MEDLINE, Cochrane Central Register of Controlled Trials, and LILACS (Latin American and Caribbean Health Science Literature) from January 1, 1946, to August 27, 2012, and performed an additional manual search. Study Selection: Randomized controlled trials and cohort studies examining nutritional supplementation in prevention and amelioration of AD among children younger than 3 years. Data Extraction: Of 92 articles, 21 met inclusion criteria. Data Synthesis: In the 21 studies, a total of 6859 participants received supplements, which included infants or mothers who were either pregnant or breastfeeding; 4134 infants or mothers served as controls. Nutritional supplementation was shown to be an effective method in preventing AD (11 of 17 studies) or decreasing its severity (5 of 6 studies). The best evidence lies with probiotics supplementation in mothers and infants in preventing development and reducing severity of AD. Specifically, Lactobacillus rhamnosus GG was effective in long-term prevention of AD development. γ-Linolenic acid reduced severity of AD. Supplementation with prebiotics and black currant seed oil (γ-linolenic acid and ω-3 combination) was effective in reducing the development of AD. Conflicting findings were reported from different research groups that performed supplementation with an amino acid-based formula. Conclusions: Certain types of nutrient supplementation are beneficial in preventing AD development and reducing its severity. Future research elucidating the mechanisms underlying the actions of nutritional supplementation on AD is necessary.
UR - http://www.scopus.com/inward/record.url?scp=84875404684&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875404684&partnerID=8YFLogxK
U2 - 10.1001/jamadermatol.2013.1495
DO - 10.1001/jamadermatol.2013.1495
M3 - Article
C2 - 23682371
AN - SCOPUS:84875404684
VL - 149
SP - 350
EP - 355
JO - JAMA Dermatology
JF - JAMA Dermatology
SN - 2168-6068
IS - 3
ER -