Effect of n-3 fatty acid-rich fish oil supplementation on the oxidation of low density lipoproteins

E. N. Frankel, E. J. Parks, R. Xu, B. O. Schneeman, P. A. Davis, J. B. German

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

This study was aimed at determining the effect of fish oil supplementation on copper-catalyzed oxidation of low density lipoproteins (LDL) from nine hypertriglyceridemic human subjects. A rapid headspace gas chromatographic method was used to measure the volatile oxidation products from LDL. Propanal and hexanal were the major volatile products formed in the oxidation of n-3 and n-6 polyunsaturated fatty acids (PUFA), respectively. Fish oil supplementation resulted in a significant increase in propanal formation from 3.7 to 13.4 nmol/mL LDL (P<0.01); it also resulted in small decreases in pentanal formation from 14.7 to 11.4 nmol/mL LDL and in hexanal formation from 138 to 108 nmol/mL LDL (P<0.05). The changes in peroxidation products paralleled the changes in LDL composition, which showed a significant increase in n-3 PUFA from 3.2 to 14.6% (P<0.01) and a decrease in n-6 PUFA from 43.7 to 35.0% (P<0.05). Propanal formation was highly and significantly correlated with n-3 PUFA content (r=0.950, P<0.001). Since total volatiles remained unchanged, this indicated that the two groups of LDL samples did not differ in overall oxidative susceptibility. Although fish oil intake did not alter the oxidative susceptibility of LDL, the chemically modified LDL particles generated a distinct pattern of volatile oxidation products that reflected changes in their fatty acid composition.

Original languageEnglish (US)
Pages (from-to)233-236
Number of pages4
JournalLipids
Volume29
Issue number4
DOIs
StatePublished - Apr 1994

Fingerprint

fatty fish
Fish Oils
Omega-3 Fatty Acids
low density lipoprotein
LDL Lipoproteins
omega-3 fatty acids
oxidation
Oxidation
polyunsaturated fatty acids
fish oils
omega-6 fatty acids
Unsaturated Fatty Acids
fatty acid composition
peroxidation
Chemical analysis
headspace analysis
Copper
Fatty Acids
Gases
copper

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science
  • Organic Chemistry
  • Cell Biology

Cite this

Frankel, E. N., Parks, E. J., Xu, R., Schneeman, B. O., Davis, P. A., & German, J. B. (1994). Effect of n-3 fatty acid-rich fish oil supplementation on the oxidation of low density lipoproteins. Lipids, 29(4), 233-236. https://doi.org/10.1007/BF02536326

Effect of n-3 fatty acid-rich fish oil supplementation on the oxidation of low density lipoproteins. / Frankel, E. N.; Parks, E. J.; Xu, R.; Schneeman, B. O.; Davis, P. A.; German, J. B.

In: Lipids, Vol. 29, No. 4, 04.1994, p. 233-236.

Research output: Contribution to journalArticle

Frankel, EN, Parks, EJ, Xu, R, Schneeman, BO, Davis, PA & German, JB 1994, 'Effect of n-3 fatty acid-rich fish oil supplementation on the oxidation of low density lipoproteins', Lipids, vol. 29, no. 4, pp. 233-236. https://doi.org/10.1007/BF02536326
Frankel, E. N. ; Parks, E. J. ; Xu, R. ; Schneeman, B. O. ; Davis, P. A. ; German, J. B. / Effect of n-3 fatty acid-rich fish oil supplementation on the oxidation of low density lipoproteins. In: Lipids. 1994 ; Vol. 29, No. 4. pp. 233-236.
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