Abstract
The distribution of OKT4+ helper and OKT8+ suppressor T-cells was studied in 41 myasthenia gravis (MG) patients and 20 normal subjects. When a purified T-cell population was studied, the mean percentage of OKT4+ cells of MG patients was slightly lower than that of normal subjects (41.6 ± 3.9% vs 43.5 ± 4.7%, p = 0.04); the mean percentage of OKT8+ cells in the former was much lower when compared with that in the latter (29.2 ± 4.5% vs 33.8 ± 6.2%, P < 0.001), resulting in a significantly higher ratio of OKT4+/OKT8+ cells in MG patients (1.45 ± 0.22% vs 1.32 ± 0.20%, p < 0.02). Neither the age of onset of disease nor sex had any effect on the distribution of T-cell subsets. The mean percentages of OKT4+ and OKT8+ cells of MG patients and normal subjects were decreased after incubation with MG sera, although only the decrease in OKT4+ cells reached a statistically significant level, but no such phenomenon was noted after incubation with normal sera. Furthermore, the percentages of OKT4+ and OKT8+ cells of normal subjects were also decreased after incubation with an anti-acetylcholine receptor (AChR) monoclonal antibody, BK73G. It is therefore concluded that the presence of anti-AChR antibody may account for the immunoregulatory aberration manifested by the loss of suppressor T-cells and the increased helper/suppressor cell ratio in MG patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 30-36 |
| Number of pages | 7 |
| Journal | Asian Pacific Journal of Allergy and Immunology |
| Volume | 3 |
| Issue number | 1 |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology and Allergy
Cite this
Effect of myasthenia serum and antiacetylcholine receptor monoclonal antibody on the distributions of T-cell subsets in myasthenia patients and normal subjects. / Chiu, H. C.; Hsieh, K. H.; Hung, T. P.; Richman, David P; Arnason, B. G.
In: Asian Pacific Journal of Allergy and Immunology, Vol. 3, No. 1, 1985, p. 30-36.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of myasthenia serum and antiacetylcholine receptor monoclonal antibody on the distributions of T-cell subsets in myasthenia patients and normal subjects
AU - Chiu, H. C.
AU - Hsieh, K. H.
AU - Hung, T. P.
AU - Richman, David P
AU - Arnason, B. G.
PY - 1985
Y1 - 1985
N2 - The distribution of OKT4+ helper and OKT8+ suppressor T-cells was studied in 41 myasthenia gravis (MG) patients and 20 normal subjects. When a purified T-cell population was studied, the mean percentage of OKT4+ cells of MG patients was slightly lower than that of normal subjects (41.6 ± 3.9% vs 43.5 ± 4.7%, p = 0.04); the mean percentage of OKT8+ cells in the former was much lower when compared with that in the latter (29.2 ± 4.5% vs 33.8 ± 6.2%, P < 0.001), resulting in a significantly higher ratio of OKT4+/OKT8+ cells in MG patients (1.45 ± 0.22% vs 1.32 ± 0.20%, p < 0.02). Neither the age of onset of disease nor sex had any effect on the distribution of T-cell subsets. The mean percentages of OKT4+ and OKT8+ cells of MG patients and normal subjects were decreased after incubation with MG sera, although only the decrease in OKT4+ cells reached a statistically significant level, but no such phenomenon was noted after incubation with normal sera. Furthermore, the percentages of OKT4+ and OKT8+ cells of normal subjects were also decreased after incubation with an anti-acetylcholine receptor (AChR) monoclonal antibody, BK73G. It is therefore concluded that the presence of anti-AChR antibody may account for the immunoregulatory aberration manifested by the loss of suppressor T-cells and the increased helper/suppressor cell ratio in MG patients.
AB - The distribution of OKT4+ helper and OKT8+ suppressor T-cells was studied in 41 myasthenia gravis (MG) patients and 20 normal subjects. When a purified T-cell population was studied, the mean percentage of OKT4+ cells of MG patients was slightly lower than that of normal subjects (41.6 ± 3.9% vs 43.5 ± 4.7%, p = 0.04); the mean percentage of OKT8+ cells in the former was much lower when compared with that in the latter (29.2 ± 4.5% vs 33.8 ± 6.2%, P < 0.001), resulting in a significantly higher ratio of OKT4+/OKT8+ cells in MG patients (1.45 ± 0.22% vs 1.32 ± 0.20%, p < 0.02). Neither the age of onset of disease nor sex had any effect on the distribution of T-cell subsets. The mean percentages of OKT4+ and OKT8+ cells of MG patients and normal subjects were decreased after incubation with MG sera, although only the decrease in OKT4+ cells reached a statistically significant level, but no such phenomenon was noted after incubation with normal sera. Furthermore, the percentages of OKT4+ and OKT8+ cells of normal subjects were also decreased after incubation with an anti-acetylcholine receptor (AChR) monoclonal antibody, BK73G. It is therefore concluded that the presence of anti-AChR antibody may account for the immunoregulatory aberration manifested by the loss of suppressor T-cells and the increased helper/suppressor cell ratio in MG patients.
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M3 - Article
VL - 3
SP - 30
EP - 36
JO - Asian Pacific Journal of Allergy and Immunology
JF - Asian Pacific Journal of Allergy and Immunology
SN - 0125-877X
IS - 1
ER -