Effect of morphine, methadone, hydromorphone or oxymorphone on the thermal threshold, following intravenous or buccal administration to cats

Bruno H Pypendop, Yael Shilo-Benjamini, Jan Ilkiw

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVE: To determine the effects of morphine, methadone, hydromorphone or oxymorphone on the thermal threshold in cats, following buccal and intravenous (IV) administration.

STUDY DESIGN: Randomized crossover study.

ANIMALS: Six healthy adult female ovariohysterectomized cats weighing 4.5 ± 0.4 kg.

METHODS: Morphine sulfate (0.2 mg kg-1 IV or 0.5 mg kg-1 buccal), methadone hydrochloride (0.3 mg kg-1 IV or 0.75 mg kg-1 buccal), hydromorphone hydrochloride (0.1 mg kg-1 IV or 0.25 mg kg-1 buccal) or oxymorphone hydrochloride (0.1 mg kg-1 IV or 0.25 mg kg-1 buccal) were administered. All cats were administered all treatments. Skin temperature and thermal threshold were measured in duplicate prior to drug administration, and at various times up to 8 hours after drug administration. The difference between thermal threshold and skin temperature (ΔT) was analyzed.

RESULTS: Administration of methadone and hydromorphone IV resulted in significant increases in ΔT at 40 minutes after drug administration. Buccal administration of methadone resulted in significant increases in thermal threshold, although no significant difference from baseline measurement was detected at any time point. IV administration of morphine and oxymorphone, and buccal administration of morphine, hydromorphone and oxymorphone did not cause significant thermal antinociception.

CONCLUSION AND CLINICAL RELEVANCE: At the doses used in this study, IV administration of methadone and hydromorphone, and buccal administration of methadone resulted in transient thermal antinociception. The results of this study do not allow us to predict the usefulness of these drugs for providing analgesia in clinical patients.

Original languageEnglish (US)
Pages (from-to)635-642
Number of pages8
JournalVeterinary Anaesthesia and Analgesia
Volume43
Issue number6
DOIs
StatePublished - Nov 1 2016

Fingerprint

Buccal Administration
Oxymorphone
Hydromorphone
methadone
morphine
Methadone
Intravenous Administration
Morphine
Cats
Cheek
Hot Temperature
cats
heat
intravenous injection
drugs
skin temperature
Skin Temperature
Pharmaceutical Preparations
analgesia
Analgesia

Keywords

  • buccal
  • cats
  • intravenous
  • opioids
  • thermal threshold

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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title = "Effect of morphine, methadone, hydromorphone or oxymorphone on the thermal threshold, following intravenous or buccal administration to cats",
abstract = "OBJECTIVE: To determine the effects of morphine, methadone, hydromorphone or oxymorphone on the thermal threshold in cats, following buccal and intravenous (IV) administration.STUDY DESIGN: Randomized crossover study.ANIMALS: Six healthy adult female ovariohysterectomized cats weighing 4.5 ± 0.4 kg.METHODS: Morphine sulfate (0.2 mg kg-1 IV or 0.5 mg kg-1 buccal), methadone hydrochloride (0.3 mg kg-1 IV or 0.75 mg kg-1 buccal), hydromorphone hydrochloride (0.1 mg kg-1 IV or 0.25 mg kg-1 buccal) or oxymorphone hydrochloride (0.1 mg kg-1 IV or 0.25 mg kg-1 buccal) were administered. All cats were administered all treatments. Skin temperature and thermal threshold were measured in duplicate prior to drug administration, and at various times up to 8 hours after drug administration. The difference between thermal threshold and skin temperature (ΔT) was analyzed.RESULTS: Administration of methadone and hydromorphone IV resulted in significant increases in ΔT at 40 minutes after drug administration. Buccal administration of methadone resulted in significant increases in thermal threshold, although no significant difference from baseline measurement was detected at any time point. IV administration of morphine and oxymorphone, and buccal administration of morphine, hydromorphone and oxymorphone did not cause significant thermal antinociception.CONCLUSION AND CLINICAL RELEVANCE: At the doses used in this study, IV administration of methadone and hydromorphone, and buccal administration of methadone resulted in transient thermal antinociception. The results of this study do not allow us to predict the usefulness of these drugs for providing analgesia in clinical patients.",
keywords = "buccal, cats, intravenous, opioids, thermal threshold",
author = "Pypendop, {Bruno H} and Yael Shilo-Benjamini and Jan Ilkiw",
year = "2016",
month = "11",
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doi = "10.1111/vaa.12356",
language = "English (US)",
volume = "43",
pages = "635--642",
journal = "Veterinary Anaesthesia and Analgesia",
issn = "1467-2987",
publisher = "Wiley-Blackwell",
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T1 - Effect of morphine, methadone, hydromorphone or oxymorphone on the thermal threshold, following intravenous or buccal administration to cats

AU - Pypendop, Bruno H

AU - Shilo-Benjamini, Yael

AU - Ilkiw, Jan

PY - 2016/11/1

Y1 - 2016/11/1

N2 - OBJECTIVE: To determine the effects of morphine, methadone, hydromorphone or oxymorphone on the thermal threshold in cats, following buccal and intravenous (IV) administration.STUDY DESIGN: Randomized crossover study.ANIMALS: Six healthy adult female ovariohysterectomized cats weighing 4.5 ± 0.4 kg.METHODS: Morphine sulfate (0.2 mg kg-1 IV or 0.5 mg kg-1 buccal), methadone hydrochloride (0.3 mg kg-1 IV or 0.75 mg kg-1 buccal), hydromorphone hydrochloride (0.1 mg kg-1 IV or 0.25 mg kg-1 buccal) or oxymorphone hydrochloride (0.1 mg kg-1 IV or 0.25 mg kg-1 buccal) were administered. All cats were administered all treatments. Skin temperature and thermal threshold were measured in duplicate prior to drug administration, and at various times up to 8 hours after drug administration. The difference between thermal threshold and skin temperature (ΔT) was analyzed.RESULTS: Administration of methadone and hydromorphone IV resulted in significant increases in ΔT at 40 minutes after drug administration. Buccal administration of methadone resulted in significant increases in thermal threshold, although no significant difference from baseline measurement was detected at any time point. IV administration of morphine and oxymorphone, and buccal administration of morphine, hydromorphone and oxymorphone did not cause significant thermal antinociception.CONCLUSION AND CLINICAL RELEVANCE: At the doses used in this study, IV administration of methadone and hydromorphone, and buccal administration of methadone resulted in transient thermal antinociception. The results of this study do not allow us to predict the usefulness of these drugs for providing analgesia in clinical patients.

AB - OBJECTIVE: To determine the effects of morphine, methadone, hydromorphone or oxymorphone on the thermal threshold in cats, following buccal and intravenous (IV) administration.STUDY DESIGN: Randomized crossover study.ANIMALS: Six healthy adult female ovariohysterectomized cats weighing 4.5 ± 0.4 kg.METHODS: Morphine sulfate (0.2 mg kg-1 IV or 0.5 mg kg-1 buccal), methadone hydrochloride (0.3 mg kg-1 IV or 0.75 mg kg-1 buccal), hydromorphone hydrochloride (0.1 mg kg-1 IV or 0.25 mg kg-1 buccal) or oxymorphone hydrochloride (0.1 mg kg-1 IV or 0.25 mg kg-1 buccal) were administered. All cats were administered all treatments. Skin temperature and thermal threshold were measured in duplicate prior to drug administration, and at various times up to 8 hours after drug administration. The difference between thermal threshold and skin temperature (ΔT) was analyzed.RESULTS: Administration of methadone and hydromorphone IV resulted in significant increases in ΔT at 40 minutes after drug administration. Buccal administration of methadone resulted in significant increases in thermal threshold, although no significant difference from baseline measurement was detected at any time point. IV administration of morphine and oxymorphone, and buccal administration of morphine, hydromorphone and oxymorphone did not cause significant thermal antinociception.CONCLUSION AND CLINICAL RELEVANCE: At the doses used in this study, IV administration of methadone and hydromorphone, and buccal administration of methadone resulted in transient thermal antinociception. The results of this study do not allow us to predict the usefulness of these drugs for providing analgesia in clinical patients.

KW - buccal

KW - cats

KW - intravenous

KW - opioids

KW - thermal threshold

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