Effect of methylphenidate on executive functioning in adults with attention-deficit/hyperactivity disorder: Normalization of behavior but not related brain activity

Julie B Schweitzer, Douglas O. Lee, Russell B. Hanford, Caroline F. Zink, Timothy D. Ely, Malle A. Tagamets, John M. Hoffman, Scott T. Grafton, Clinton D. Kilts

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

We examined the effect of prolonged methylphenidate (MPH) treatment on the functional neuroanatomy of executive functioning in adult men with attention-deficit/hyperactivity disorder (ADHD). Positron emission tomography with [ 15O] water measured alterations of regional cerebral blood flow (rCBF) during the Paced Auditory Serial Addition Task and a control task in 10 ADHD and 11 normal control men. Attention-deficit/hyperactivity disorder men were imaged unmedicated and after a clinically optimal dose of MPH for 3 weeks. Methylphenidate improved ADHD task performance, reduced rCBF in the prefrontal cortex (PFC), and increased rCBF in the right thalamus and precentral gyrus. Comparisons between the ADHD and normal control groups showed that normal control participants exhibited greater anterior cingulate cortex and temporal gyrus rCBF than ADHD participants under both conditions. Executive functioning was associated with greater subcortical (basal ganglia and cerebellar vermis) activation in the ADHD than normal control group under both conditions. Methylphenidate does not normalize task-related activity in ADHD. Task-related rCBF decreases in the PFC may be due to improved filtering out of task-irrelevant stimuli by way of MPH-mediated dopamine release in the PFC.

Original languageEnglish (US)
Pages (from-to)597-606
Number of pages10
JournalBiological Psychiatry
Volume56
Issue number8
DOIs
StatePublished - Oct 15 2004
Externally publishedYes

Fingerprint

Methylphenidate
Attention Deficit Disorder with Hyperactivity
Cerebrovascular Circulation
Regional Blood Flow
Brain
Prefrontal Cortex
Gyrus Cinguli
Neuroanatomy
Control Groups
Task Performance and Analysis
Frontal Lobe
Temporal Lobe
Basal Ganglia
Thalamus
Positron-Emission Tomography
Dopamine
Water

Keywords

  • ADHD
  • executive function
  • methylphenidate
  • PASAT
  • PET
  • working memory

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Effect of methylphenidate on executive functioning in adults with attention-deficit/hyperactivity disorder : Normalization of behavior but not related brain activity. / Schweitzer, Julie B; Lee, Douglas O.; Hanford, Russell B.; Zink, Caroline F.; Ely, Timothy D.; Tagamets, Malle A.; Hoffman, John M.; Grafton, Scott T.; Kilts, Clinton D.

In: Biological Psychiatry, Vol. 56, No. 8, 15.10.2004, p. 597-606.

Research output: Contribution to journalArticle

Schweitzer, Julie B ; Lee, Douglas O. ; Hanford, Russell B. ; Zink, Caroline F. ; Ely, Timothy D. ; Tagamets, Malle A. ; Hoffman, John M. ; Grafton, Scott T. ; Kilts, Clinton D. / Effect of methylphenidate on executive functioning in adults with attention-deficit/hyperactivity disorder : Normalization of behavior but not related brain activity. In: Biological Psychiatry. 2004 ; Vol. 56, No. 8. pp. 597-606.
@article{3a2717eee7f542678260458d7e46426f,
title = "Effect of methylphenidate on executive functioning in adults with attention-deficit/hyperactivity disorder: Normalization of behavior but not related brain activity",
abstract = "We examined the effect of prolonged methylphenidate (MPH) treatment on the functional neuroanatomy of executive functioning in adult men with attention-deficit/hyperactivity disorder (ADHD). Positron emission tomography with [ 15O] water measured alterations of regional cerebral blood flow (rCBF) during the Paced Auditory Serial Addition Task and a control task in 10 ADHD and 11 normal control men. Attention-deficit/hyperactivity disorder men were imaged unmedicated and after a clinically optimal dose of MPH for 3 weeks. Methylphenidate improved ADHD task performance, reduced rCBF in the prefrontal cortex (PFC), and increased rCBF in the right thalamus and precentral gyrus. Comparisons between the ADHD and normal control groups showed that normal control participants exhibited greater anterior cingulate cortex and temporal gyrus rCBF than ADHD participants under both conditions. Executive functioning was associated with greater subcortical (basal ganglia and cerebellar vermis) activation in the ADHD than normal control group under both conditions. Methylphenidate does not normalize task-related activity in ADHD. Task-related rCBF decreases in the PFC may be due to improved filtering out of task-irrelevant stimuli by way of MPH-mediated dopamine release in the PFC.",
keywords = "ADHD, executive function, methylphenidate, PASAT, PET, working memory",
author = "Schweitzer, {Julie B} and Lee, {Douglas O.} and Hanford, {Russell B.} and Zink, {Caroline F.} and Ely, {Timothy D.} and Tagamets, {Malle A.} and Hoffman, {John M.} and Grafton, {Scott T.} and Kilts, {Clinton D.}",
year = "2004",
month = "10",
day = "15",
doi = "10.1016/j.biopsych.2004.07.011",
language = "English (US)",
volume = "56",
pages = "597--606",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "8",

}

TY - JOUR

T1 - Effect of methylphenidate on executive functioning in adults with attention-deficit/hyperactivity disorder

T2 - Normalization of behavior but not related brain activity

AU - Schweitzer, Julie B

AU - Lee, Douglas O.

AU - Hanford, Russell B.

AU - Zink, Caroline F.

AU - Ely, Timothy D.

AU - Tagamets, Malle A.

AU - Hoffman, John M.

AU - Grafton, Scott T.

AU - Kilts, Clinton D.

PY - 2004/10/15

Y1 - 2004/10/15

N2 - We examined the effect of prolonged methylphenidate (MPH) treatment on the functional neuroanatomy of executive functioning in adult men with attention-deficit/hyperactivity disorder (ADHD). Positron emission tomography with [ 15O] water measured alterations of regional cerebral blood flow (rCBF) during the Paced Auditory Serial Addition Task and a control task in 10 ADHD and 11 normal control men. Attention-deficit/hyperactivity disorder men were imaged unmedicated and after a clinically optimal dose of MPH for 3 weeks. Methylphenidate improved ADHD task performance, reduced rCBF in the prefrontal cortex (PFC), and increased rCBF in the right thalamus and precentral gyrus. Comparisons between the ADHD and normal control groups showed that normal control participants exhibited greater anterior cingulate cortex and temporal gyrus rCBF than ADHD participants under both conditions. Executive functioning was associated with greater subcortical (basal ganglia and cerebellar vermis) activation in the ADHD than normal control group under both conditions. Methylphenidate does not normalize task-related activity in ADHD. Task-related rCBF decreases in the PFC may be due to improved filtering out of task-irrelevant stimuli by way of MPH-mediated dopamine release in the PFC.

AB - We examined the effect of prolonged methylphenidate (MPH) treatment on the functional neuroanatomy of executive functioning in adult men with attention-deficit/hyperactivity disorder (ADHD). Positron emission tomography with [ 15O] water measured alterations of regional cerebral blood flow (rCBF) during the Paced Auditory Serial Addition Task and a control task in 10 ADHD and 11 normal control men. Attention-deficit/hyperactivity disorder men were imaged unmedicated and after a clinically optimal dose of MPH for 3 weeks. Methylphenidate improved ADHD task performance, reduced rCBF in the prefrontal cortex (PFC), and increased rCBF in the right thalamus and precentral gyrus. Comparisons between the ADHD and normal control groups showed that normal control participants exhibited greater anterior cingulate cortex and temporal gyrus rCBF than ADHD participants under both conditions. Executive functioning was associated with greater subcortical (basal ganglia and cerebellar vermis) activation in the ADHD than normal control group under both conditions. Methylphenidate does not normalize task-related activity in ADHD. Task-related rCBF decreases in the PFC may be due to improved filtering out of task-irrelevant stimuli by way of MPH-mediated dopamine release in the PFC.

KW - ADHD

KW - executive function

KW - methylphenidate

KW - PASAT

KW - PET

KW - working memory

UR - http://www.scopus.com/inward/record.url?scp=5044228027&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=5044228027&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2004.07.011

DO - 10.1016/j.biopsych.2004.07.011

M3 - Article

C2 - 15476690

AN - SCOPUS:5044228027

VL - 56

SP - 597

EP - 606

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 8

ER -