Effect of methylene blue on refractory neonatal hypotension

W. Driscoll, S. Thurin, V. Carrion, Robin H Steinhorn, F. C. Morin

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Excess nitric oxide is a mediator of the hypotension in septic shock. Nitric oxide dilates vascular smooth muscle through activation of soluble guanylate cyclase. We report the increase in blood pressure caused by methylene blue (MB), a soluble guanylate cyclase inhibitor, in five neonates with presumed septic shock unresponsive to colloids, inotropic agents, and corticosteroids. MB was given intravenously at a dose of 1 mg/kg during a 1- hour period. MB increased blood pressure in each patient (average, 33% ± 20%). Blood pressure subsequently decreased to near baseline values in three patients, who then received a second infusion of MB. Blood pressure again increased in these patients. Three of five patients were weaned from inotropic support within 72 hours. Three of five patients survived and were discharged home. We suggest that MB increased blood pressure in these neonates with refractory hypotension.

Original languageEnglish (US)
Pages (from-to)904-908
Number of pages5
JournalJournal of Pediatrics
Volume129
Issue number6
StatePublished - 1996
Externally publishedYes

Fingerprint

Methylene Blue
Hypotension
Blood Pressure
Septic Shock
Nitric Oxide
Newborn Infant
Colloids
Vascular Smooth Muscle
Adrenal Cortex Hormones
Soluble Guanylyl Cyclase

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Driscoll, W., Thurin, S., Carrion, V., Steinhorn, R. H., & Morin, F. C. (1996). Effect of methylene blue on refractory neonatal hypotension. Journal of Pediatrics, 129(6), 904-908.

Effect of methylene blue on refractory neonatal hypotension. / Driscoll, W.; Thurin, S.; Carrion, V.; Steinhorn, Robin H; Morin, F. C.

In: Journal of Pediatrics, Vol. 129, No. 6, 1996, p. 904-908.

Research output: Contribution to journalArticle

Driscoll, W, Thurin, S, Carrion, V, Steinhorn, RH & Morin, FC 1996, 'Effect of methylene blue on refractory neonatal hypotension', Journal of Pediatrics, vol. 129, no. 6, pp. 904-908.
Driscoll W, Thurin S, Carrion V, Steinhorn RH, Morin FC. Effect of methylene blue on refractory neonatal hypotension. Journal of Pediatrics. 1996;129(6):904-908.
Driscoll, W. ; Thurin, S. ; Carrion, V. ; Steinhorn, Robin H ; Morin, F. C. / Effect of methylene blue on refractory neonatal hypotension. In: Journal of Pediatrics. 1996 ; Vol. 129, No. 6. pp. 904-908.
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