Effect of maropitant, a neurokinin 1 receptor antagonist, on anesthetic requirements during noxious visceral stimulation of the ovary in dogs

Pedro Boscan, Eric Monnet, Khursheed Mama, David C. Twedt, Jonathan Congdon, Eugene Steffey

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objective-To determine the anesthetic-sparing effect of maropitant, a neurokinin 1 receptor antagonist, during noxious visceral stimulation of the ovary and ovarian ligament in dogs. Animals-Eight 1-year-old female dogs. Procedures-Dogs were anesthetized with sevoflurane. Following instrumentation and stabilization, the right ovary and ovarian ligament were accessed by use of laparoscopy. The ovary was stimulated with a traction force of 6.61 N. The minimum alveolar concentration (MAC) was determined before and after 2 doses of maropitant. Results-The sevoflurane MAC value was 2.12 ± 0.4% during stimulation without treatment (control). Administration of maropitant (1 mg/kg, IV, followed by 30 μg/kg/h, IV) decreased the sevoflurane MAC to 1.61 ± 0.4% (24% decrease). A higher maropitant dose (5 mg/kg, IV, followed by 150 μg/kg/h, IV) decreased the MAC to 1.48 ± 0.4% (30% decrease). Conclusions and Clinical Relevance-Maropitant decreased the anesthetic requirements during visceral stimulation of the ovary and ovarian ligament in dogs. Results suggest the potential role for neurokinin 1 receptor antagonists to manage ovarian and visceral pain.

Original languageEnglish (US)
Pages (from-to)1576-1579
Number of pages4
JournalAmerican Journal of Veterinary Research
Volume72
Issue number12
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

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Neurokinin-1 Receptor Antagonists
anesthetics
Anesthetics
antagonists
Ovary
ligaments
Dogs
receptors
Ligaments
dogs
Ovulation Induction
traction (mechanics)
laparoscopy
Visceral Pain
instrumentation
dosage
Traction
pain
Laparoscopy
maropitant

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effect of maropitant, a neurokinin 1 receptor antagonist, on anesthetic requirements during noxious visceral stimulation of the ovary in dogs. / Boscan, Pedro; Monnet, Eric; Mama, Khursheed; Twedt, David C.; Congdon, Jonathan; Steffey, Eugene.

In: American Journal of Veterinary Research, Vol. 72, No. 12, 01.01.2011, p. 1576-1579.

Research output: Contribution to journalArticle

Boscan, Pedro ; Monnet, Eric ; Mama, Khursheed ; Twedt, David C. ; Congdon, Jonathan ; Steffey, Eugene. / Effect of maropitant, a neurokinin 1 receptor antagonist, on anesthetic requirements during noxious visceral stimulation of the ovary in dogs. In: American Journal of Veterinary Research. 2011 ; Vol. 72, No. 12. pp. 1576-1579.
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