Effect of manganese deficiency on insulin secretion and carbohydrate homeostasis in rats

D. L. Baly, D. L. Curry, Carl L Keen, L. S. Hurley

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40 Scopus citations

Abstract

The effects of manganese (Mn) deficiency on carbohydrate metabolism in the Sprague-Dawley rat were investigated. Oral glucose tolerance tests were performed on offspring from Mn-sufficient females rats fed 45 μg Mn per gram diet (C-C), offspring from Mn-deficient female rats fed 1 μg Mn per gram diet (DI-DI) and rats not exposed to Mn deficiency in utero but fed DI diet from weaning to maturity (DI). Mn-deficient rats, DI and DI-DI, had significantly lower concentrations of Mn in liver, kidney, heart and pancreas than controls. DI-DI rats responded with a diabetic type of glucose tolerance curve when given oral glucose. Insulin levels of DI-DI rats were not commensurate with their high glucose levels. Measurements made by using an isolated perfused-pancreas preparation indicate that insulin output due to release of steroid hormone was 76% of control levels in DI-DI rats. This suggests either lower insulin stores or impaired release of insulin in DI-DI rats. Second phase insulin release was also significantly lower in DI-DI rats than in controls. Pancreatic insulin content was 63% of control levels in DI-DI rats, further supporting the idea of lower insulin stores in Mn-deficient rats. No differences in plasma glucose levels were observed between DI rats and controls after an oral-glucose load. These findings indicate that dietary Mn-deficiecy can result in impaired insulin secretion producing impaired carbohydrate metabolism; however, the timing of the deficiency may be a critical factor in the expression of this abnormality.

Original languageEnglish (US)
Pages (from-to)1438-1446
Number of pages9
JournalJournal of Nutrition
Volume114
Issue number8
StatePublished - 1984

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

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    Baly, D. L., Curry, D. L., Keen, C. L., & Hurley, L. S. (1984). Effect of manganese deficiency on insulin secretion and carbohydrate homeostasis in rats. Journal of Nutrition, 114(8), 1438-1446.