Abstract
Morphological studies were made of the effect of 0.8 ppm ozone on lungs of 70-day-old male rats at the end of a 3-day exposure, after 6, 9, or 30 days of recovery, and at the end of a 3-day re-exposure beginning either 6 or 27 days after the initial exposure ceased. After 6 days of recovery, the residual lesion consisted of occasional cells lining proximal alveoli that were intermediate in form between types 1 and 2 epithelial cells and a few undifferentiated bronchiolar epithelial cells. By 9 days, the only evidence of previous damage was the presence of a few immature ciliated and nonciliated (Clara) bronchiolar cells. Re-exposure to 0.8 ppm at 6 or 27 days produced lesions indistinguishable from those observed after only one exposure. The findings are in agreement with interpretations made on the basis of biochemical measurements. It was concluded that the bronchiolar and alveolar type 1 epithelial cells that repopulate damaged sites by 6 days after the end of exposure are of approximately the same degree of susceptibility to ozone as their pre-exposure counterparts.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 400-411 |
| Number of pages | 12 |
| Journal | Experimental and Molecular Pathology |
| Volume | 29 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1978 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Biology
- Clinical Biochemistry
Cite this
Effect of low level of ozone on rat lungs. II. Morphological responses during recovery and re-exposure. / Plopper, Charles; Chow, C. K.; Dungworth, D. L.; Brummer, M.; Nemeth, T. J.
In: Experimental and Molecular Pathology, Vol. 29, No. 3, 01.01.1978, p. 400-411.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of low level of ozone on rat lungs. II. Morphological responses during recovery and re-exposure
AU - Plopper, Charles
AU - Chow, C. K.
AU - Dungworth, D. L.
AU - Brummer, M.
AU - Nemeth, T. J.
PY - 1978/1/1
Y1 - 1978/1/1
N2 - Morphological studies were made of the effect of 0.8 ppm ozone on lungs of 70-day-old male rats at the end of a 3-day exposure, after 6, 9, or 30 days of recovery, and at the end of a 3-day re-exposure beginning either 6 or 27 days after the initial exposure ceased. After 6 days of recovery, the residual lesion consisted of occasional cells lining proximal alveoli that were intermediate in form between types 1 and 2 epithelial cells and a few undifferentiated bronchiolar epithelial cells. By 9 days, the only evidence of previous damage was the presence of a few immature ciliated and nonciliated (Clara) bronchiolar cells. Re-exposure to 0.8 ppm at 6 or 27 days produced lesions indistinguishable from those observed after only one exposure. The findings are in agreement with interpretations made on the basis of biochemical measurements. It was concluded that the bronchiolar and alveolar type 1 epithelial cells that repopulate damaged sites by 6 days after the end of exposure are of approximately the same degree of susceptibility to ozone as their pre-exposure counterparts.
AB - Morphological studies were made of the effect of 0.8 ppm ozone on lungs of 70-day-old male rats at the end of a 3-day exposure, after 6, 9, or 30 days of recovery, and at the end of a 3-day re-exposure beginning either 6 or 27 days after the initial exposure ceased. After 6 days of recovery, the residual lesion consisted of occasional cells lining proximal alveoli that were intermediate in form between types 1 and 2 epithelial cells and a few undifferentiated bronchiolar epithelial cells. By 9 days, the only evidence of previous damage was the presence of a few immature ciliated and nonciliated (Clara) bronchiolar cells. Re-exposure to 0.8 ppm at 6 or 27 days produced lesions indistinguishable from those observed after only one exposure. The findings are in agreement with interpretations made on the basis of biochemical measurements. It was concluded that the bronchiolar and alveolar type 1 epithelial cells that repopulate damaged sites by 6 days after the end of exposure are of approximately the same degree of susceptibility to ozone as their pre-exposure counterparts.
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U2 - 10.1016/0014-4800(78)90081-3
DO - 10.1016/0014-4800(78)90081-3
M3 - Article
C2 - 720547
AN - SCOPUS:0018078575
VL - 29
SP - 400
EP - 411
JO - Experimental and Molecular Pathology
JF - Experimental and Molecular Pathology
SN - 0014-4800
IS - 3
ER -