Abstract
The concentrations of total protein, albumin and retinol-binding protein, a major transport protein for vitamin A, are significantly decreased by protein-calorie malnutrition. Weight-loss diets, sometimes involving severe energy deficits over prolonged periods of time, are common in the United States. The effect, if any, of prolonged low calorie weight-loss diets with normal intakes of protein on albumin, total protein and retinol-binding protein concentrations (and potentially on vitamin A metabolism) had not been extensively studied. We measured total protein, albumin, apo + holo retinol-binding protein and holo-free- and holo-transthyretin-bound retinol-binding protein concentrations during the course of a nutritionally adequate weight-loss diet (50% calorie restriction). We found that this type of dieting did not affect total protein, albumin or apo + holo, holo-free or holo-transthretin-bound retinol-binding protein concentrations significantly. This suggests that protein intake is more critical than caloric intake for retinol-binding protein status.
Original language | English (US) |
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Pages (from-to) | 484-486 |
Number of pages | 3 |
Journal | The Journal of Nutritional Biochemistry |
Volume | 1 |
Issue number | 9 |
DOIs | |
State | Published - 1990 |
Externally published | Yes |
Keywords
- calorie restriction
- human
- retinol-binding protein
- serum
- transthyretin
ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism