Effect of low-calorie diets on plasma retinol-binding protein concentrations in overweight women

Betty Jane Burri, Terry R. Neidlinger, Marta Van Loan, Nancy L. Keim

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The concentrations of total protein, albumin and retinol-binding protein, a major transport protein for vitamin A, are significantly decreased by protein-calorie malnutrition. Weight-loss diets, sometimes involving severe energy deficits over prolonged periods of time, are common in the United States. The effect, if any, of prolonged low calorie weight-loss diets with normal intakes of protein on albumin, total protein and retinol-binding protein concentrations (and potentially on vitamin A metabolism) had not been extensively studied. We measured total protein, albumin, apo + holo retinol-binding protein and holo-free- and holo-transthyretin-bound retinol-binding protein concentrations during the course of a nutritionally adequate weight-loss diet (50% calorie restriction). We found that this type of dieting did not affect total protein, albumin or apo + holo, holo-free or holo-transthretin-bound retinol-binding protein concentrations significantly. This suggests that protein intake is more critical than caloric intake for retinol-binding protein status.

Original languageEnglish (US)
Pages (from-to)484-486
Number of pages3
JournalThe Journal of Nutritional Biochemistry
Issue number9
StatePublished - 1990
Externally publishedYes


  • calorie restriction
  • human
  • retinol-binding protein
  • serum
  • transthyretin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism


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