Effect of lactulose, neomycin and antacid on colonic pH recorded continuously with an implanted electrode

Nirmal S Mann, B. B. Borkar, K. P. Narenderan, R. S. Kadian, Surinder K Mann, R. L. Martin

Research output: Contribution to journalArticle

2 Scopus citations


Colonic pH was continuously monitored by a pH electrode implanted in the transverse colon of rats over a 24-hr period. Lactulose significantly reduced the colonic pH to 5.37 ± .39 from a fasting value of 6.77 ± .75. Pretreatment with neomycin or concomitant use of a nonabsorbable antacid prevented lactulose-induced reduction in the colonic pH. The clinical implication of the study is that combined use of lactulose with neomycin or high doses of non-absorbable antacids in the treatment of chronic portasystemic encephalopathy may be undesirable.

Original languageEnglish (US)
Pages (from-to)141-145
Number of pages5
JournalAmerican Journal of Gastroenterology
Issue number2
StatePublished - 1979
Externally publishedYes


ASJC Scopus subject areas

  • Gastroenterology

Cite this