Colonic pH was continuously monitored by a pH electrode implanted in the transverse colon of rats over a 24-hr period. Lactulose significantly reduced the colonic pH to 5.37 ± .39 from a fasting value of 6.77 ± .75. Pretreatment with neomycin or concomitant use of a nonabsorbable antacid prevented lactulose-induced reduction in the colonic pH. The clinical implication of the study is that combined use of lactulose with neomycin or high doses of non-absorbable antacids in the treatment of chronic portasystemic encephalopathy may be undesirable.
|Original language||English (US)|
|Number of pages||5|
|Journal||American Journal of Gastroenterology|
|State||Published - 1979|
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