Abstract
Colonic pH was continuously monitored by a pH electrode implanted in the transverse colon of rats over a 24-hr period. Lactulose significantly reduced the colonic pH to 5.37 ± .39 from a fasting value of 6.77 ± .75. Pretreatment with neomycin or concomitant use of a nonabsorbable antacid prevented lactulose-induced reduction in the colonic pH. The clinical implication of the study is that combined use of lactulose with neomycin or high doses of non-absorbable antacids in the treatment of chronic portasystemic encephalopathy may be undesirable.
Original language | English (US) |
---|---|
Pages (from-to) | 141-145 |
Number of pages | 5 |
Journal | American Journal of Gastroenterology |
Volume | 72 |
Issue number | 2 |
State | Published - 1979 |
Externally published | Yes |
ASJC Scopus subject areas
- Gastroenterology