Abstract
Colonic pH was continuously monitored by a pH electrode implanted in the transverse colon of rats over a 24-hr period. Lactulose significantly reduced the colonic pH to 5.37 ± .39 from a fasting value of 6.77 ± .75. Pretreatment with neomycin or concomitant use of a nonabsorbable antacid prevented lactulose-induced reduction in the colonic pH. The clinical implication of the study is that combined use of lactulose with neomycin or high doses of non-absorbable antacids in the treatment of chronic portasystemic encephalopathy may be undesirable.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 141-145 |
| Number of pages | 5 |
| Journal | American Journal of Gastroenterology |
| Volume | 72 |
| Issue number | 2 |
| State | Published - 1979 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Gastroenterology
Cite this
Effect of lactulose, neomycin and antacid on colonic pH recorded continuously with an implanted electrode. / Mann, Nirmal S; Borkar, B. B.; Narenderan, K. P.; Kadian, R. S.; Mann, Surinder K; Martin, R. L.
In: American Journal of Gastroenterology, Vol. 72, No. 2, 1979, p. 141-145.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of lactulose, neomycin and antacid on colonic pH recorded continuously with an implanted electrode
AU - Mann, Nirmal S
AU - Borkar, B. B.
AU - Narenderan, K. P.
AU - Kadian, R. S.
AU - Mann, Surinder K
AU - Martin, R. L.
PY - 1979
Y1 - 1979
N2 - Colonic pH was continuously monitored by a pH electrode implanted in the transverse colon of rats over a 24-hr period. Lactulose significantly reduced the colonic pH to 5.37 ± .39 from a fasting value of 6.77 ± .75. Pretreatment with neomycin or concomitant use of a nonabsorbable antacid prevented lactulose-induced reduction in the colonic pH. The clinical implication of the study is that combined use of lactulose with neomycin or high doses of non-absorbable antacids in the treatment of chronic portasystemic encephalopathy may be undesirable.
AB - Colonic pH was continuously monitored by a pH electrode implanted in the transverse colon of rats over a 24-hr period. Lactulose significantly reduced the colonic pH to 5.37 ± .39 from a fasting value of 6.77 ± .75. Pretreatment with neomycin or concomitant use of a nonabsorbable antacid prevented lactulose-induced reduction in the colonic pH. The clinical implication of the study is that combined use of lactulose with neomycin or high doses of non-absorbable antacids in the treatment of chronic portasystemic encephalopathy may be undesirable.
UR - http://www.scopus.com/inward/record.url?scp=0018366040&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018366040&partnerID=8YFLogxK
M3 - Article
C2 - 38663
AN - SCOPUS:0018366040
VL - 72
SP - 141
EP - 145
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
SN - 0002-9270
IS - 2
ER -