Effect of lactulose, neomycin and antacid on colonic pH recorded continuously with an implanted electrode

Nirmal S Mann; B. B. Borkar; K. P. Narenderan; R. S. Kadian; Surinder K Mann; R. L. Martin

Effect of lactulose, neomycin and antacid on colonic pH recorded continuously with an implanted electrode

Nirmal S Mann, B. B. Borkar, K. P. Narenderan, R. S. Kadian, Surinder K Mann, R. L. Martin

Research output: Contribution to journal › Article › peer-review

Abstract

Colonic pH was continuously monitored by a pH electrode implanted in the transverse colon of rats over a 24-hr period. Lactulose significantly reduced the colonic pH to 5.37 ± .39 from a fasting value of 6.77 ± .75. Pretreatment with neomycin or concomitant use of a nonabsorbable antacid prevented lactulose-induced reduction in the colonic pH. The clinical implication of the study is that combined use of lactulose with neomycin or high doses of non-absorbable antacids in the treatment of chronic portasystemic encephalopathy may be undesirable.

Original language	English (US)
Pages (from-to)	141-145
Number of pages	5
Journal	American Journal of Gastroenterology
Volume	72
Issue number	2
State	Published - 1979
Externally published	Yes

ASJC Scopus subject areas

Gastroenterology

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title = "Effect of lactulose, neomycin and antacid on colonic pH recorded continuously with an implanted electrode",

abstract = "Colonic pH was continuously monitored by a pH electrode implanted in the transverse colon of rats over a 24-hr period. Lactulose significantly reduced the colonic pH to 5.37 ± .39 from a fasting value of 6.77 ± .75. Pretreatment with neomycin or concomitant use of a nonabsorbable antacid prevented lactulose-induced reduction in the colonic pH. The clinical implication of the study is that combined use of lactulose with neomycin or high doses of non-absorbable antacids in the treatment of chronic portasystemic encephalopathy may be undesirable.",

author = "Mann, {Nirmal S} and Borkar, {B. B.} and Narenderan, {K. P.} and Kadian, {R. S.} and Mann, {Surinder K} and Martin, {R. L.}",

year = "1979",

language = "English (US)",

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pages = "141--145",

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AU - Mann, Nirmal S

AU - Borkar, B. B.

AU - Narenderan, K. P.

AU - Kadian, R. S.

AU - Mann, Surinder K

AU - Martin, R. L.

PY - 1979

Y1 - 1979

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AB - Colonic pH was continuously monitored by a pH electrode implanted in the transverse colon of rats over a 24-hr period. Lactulose significantly reduced the colonic pH to 5.37 ± .39 from a fasting value of 6.77 ± .75. Pretreatment with neomycin or concomitant use of a nonabsorbable antacid prevented lactulose-induced reduction in the colonic pH. The clinical implication of the study is that combined use of lactulose with neomycin or high doses of non-absorbable antacids in the treatment of chronic portasystemic encephalopathy may be undesirable.

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