Abstract
Colonic pH was continuously monitored by a pH electrode implanted in the transverse colon of rats over a 24-hr period. Lactulose significantly reduced the colonic pH to 5.37 ± .39 from a fasting value of 6.77 ± .75. Pretreatment with neomycin or concomitant use of a nonabsorbable antacid prevented lactulose-induced reduction in the colonic pH. The clinical implication of the study is that combined use of lactulose with neomycin or high doses of non-absorbable antacids in the treatment of chronic portasystemic encephalopathy may be undesirable.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 141-145 |
| Number of pages | 5 |
| Journal | American Journal of Gastroenterology |
| Volume | 72 |
| Issue number | 2 |
| State | Published - 1979 |
| Externally published | Yes |
ASJC Scopus subject areas
- Gastroenterology
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Mann, N. S., Borkar, B. B., Narenderan, K. P., Kadian, R. S., Mann, S. K., & Martin, R. L. (1979). Effect of lactulose, neomycin and antacid on colonic pH recorded continuously with an implanted electrode. American Journal of Gastroenterology, 72(2), 141-145.