Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitisassociated pain

Alonso G P Guedes, Nora S. Matthews, David M. Hood

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective-To investigate the effects of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of pain associated with naturally occurring chronic laminitis. Animals-15 client-owned adult horses with chronic laminitis. Procedures-Each horse received tramadol alone or tramadol and ketamine in a randomized, crossover study (≥ 2 months between treatments). Tramadol (5 mg/kg) was administered orally every 12 hours for 1 week. When appropriate, ketamine (0.6 mg/kg/h) was administered IV for 6 hours on each of the first 3 days of tramadol administration. Noninvasive systemic blood pressure values, heart and respiratory rates, intestinal sounds, forelimb load and off-loading frequency (determined via force plate system), and plasma tumor necrosis factor-α and thromboxane B2 concentrations were assessed before (baseline) during (7 days) and after (3 days) each treatment. Results-Compared with baseline data, arterial blood pressure decreased significantly both during and after tramadol-ketamine treatment but not with tramadol alone. Forelimb off-loading frequency significantly decreased during the first 3 days of treatment with tramadol only, returning to baseline frequency thereafter. The addition of ketamine to tramadol treatment reduced off-loading frequency both during and after treatment. Forelimb load did not change with tramadol alone but increased with tramadol-ketamine treatment. Plasma concentrations of tumor necrosis factor-α and thromboxane B2 were significantly reduced with tramadol-ketamine treatment but not with tramadol alone. Conclusions and Clinical Relevance-In horses with chronic laminitis, tramadol administration induced limited analgesia, but this effect was significantly enhanced by administration of subanesthetic doses of ketamine.

Original languageEnglish (US)
Pages (from-to)610-619
Number of pages10
JournalAmerican Journal of Veterinary Research
Volume73
Issue number5
DOIs
StatePublished - May 2012
Externally publishedYes

Fingerprint

Tramadol
analgesic effect
Ketamine
ketamine
Chronic Pain
Horses
Analgesics
pain
horses
laminitis
forelimbs
thromboxanes
tumor necrosis factors
Forelimb
blood pressure
Thromboxane B2
Therapeutics
analgesia
respiratory rate
Tumor Necrosis Factor-alpha

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitisassociated pain. / Guedes, Alonso G P; Matthews, Nora S.; Hood, David M.

In: American Journal of Veterinary Research, Vol. 73, No. 5, 05.2012, p. 610-619.

Research output: Contribution to journalArticle

@article{56e0af4d86f349ba90317de796e50f46,
title = "Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitisassociated pain",
abstract = "Objective-To investigate the effects of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of pain associated with naturally occurring chronic laminitis. Animals-15 client-owned adult horses with chronic laminitis. Procedures-Each horse received tramadol alone or tramadol and ketamine in a randomized, crossover study (≥ 2 months between treatments). Tramadol (5 mg/kg) was administered orally every 12 hours for 1 week. When appropriate, ketamine (0.6 mg/kg/h) was administered IV for 6 hours on each of the first 3 days of tramadol administration. Noninvasive systemic blood pressure values, heart and respiratory rates, intestinal sounds, forelimb load and off-loading frequency (determined via force plate system), and plasma tumor necrosis factor-α and thromboxane B2 concentrations were assessed before (baseline) during (7 days) and after (3 days) each treatment. Results-Compared with baseline data, arterial blood pressure decreased significantly both during and after tramadol-ketamine treatment but not with tramadol alone. Forelimb off-loading frequency significantly decreased during the first 3 days of treatment with tramadol only, returning to baseline frequency thereafter. The addition of ketamine to tramadol treatment reduced off-loading frequency both during and after treatment. Forelimb load did not change with tramadol alone but increased with tramadol-ketamine treatment. Plasma concentrations of tumor necrosis factor-α and thromboxane B2 were significantly reduced with tramadol-ketamine treatment but not with tramadol alone. Conclusions and Clinical Relevance-In horses with chronic laminitis, tramadol administration induced limited analgesia, but this effect was significantly enhanced by administration of subanesthetic doses of ketamine.",
author = "Guedes, {Alonso G P} and Matthews, {Nora S.} and Hood, {David M.}",
year = "2012",
month = "5",
doi = "10.2460/ajvr.73.5.610",
language = "English (US)",
volume = "73",
pages = "610--619",
journal = "American Journal of Veterinary Research",
issn = "0002-9645",
publisher = "American Veterinary Medical Association",
number = "5",

}

TY - JOUR

T1 - Effect of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of chronic laminitisassociated pain

AU - Guedes, Alonso G P

AU - Matthews, Nora S.

AU - Hood, David M.

PY - 2012/5

Y1 - 2012/5

N2 - Objective-To investigate the effects of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of pain associated with naturally occurring chronic laminitis. Animals-15 client-owned adult horses with chronic laminitis. Procedures-Each horse received tramadol alone or tramadol and ketamine in a randomized, crossover study (≥ 2 months between treatments). Tramadol (5 mg/kg) was administered orally every 12 hours for 1 week. When appropriate, ketamine (0.6 mg/kg/h) was administered IV for 6 hours on each of the first 3 days of tramadol administration. Noninvasive systemic blood pressure values, heart and respiratory rates, intestinal sounds, forelimb load and off-loading frequency (determined via force plate system), and plasma tumor necrosis factor-α and thromboxane B2 concentrations were assessed before (baseline) during (7 days) and after (3 days) each treatment. Results-Compared with baseline data, arterial blood pressure decreased significantly both during and after tramadol-ketamine treatment but not with tramadol alone. Forelimb off-loading frequency significantly decreased during the first 3 days of treatment with tramadol only, returning to baseline frequency thereafter. The addition of ketamine to tramadol treatment reduced off-loading frequency both during and after treatment. Forelimb load did not change with tramadol alone but increased with tramadol-ketamine treatment. Plasma concentrations of tumor necrosis factor-α and thromboxane B2 were significantly reduced with tramadol-ketamine treatment but not with tramadol alone. Conclusions and Clinical Relevance-In horses with chronic laminitis, tramadol administration induced limited analgesia, but this effect was significantly enhanced by administration of subanesthetic doses of ketamine.

AB - Objective-To investigate the effects of ketamine hydrochloride on the analgesic effects of tramadol hydrochloride in horses with signs of pain associated with naturally occurring chronic laminitis. Animals-15 client-owned adult horses with chronic laminitis. Procedures-Each horse received tramadol alone or tramadol and ketamine in a randomized, crossover study (≥ 2 months between treatments). Tramadol (5 mg/kg) was administered orally every 12 hours for 1 week. When appropriate, ketamine (0.6 mg/kg/h) was administered IV for 6 hours on each of the first 3 days of tramadol administration. Noninvasive systemic blood pressure values, heart and respiratory rates, intestinal sounds, forelimb load and off-loading frequency (determined via force plate system), and plasma tumor necrosis factor-α and thromboxane B2 concentrations were assessed before (baseline) during (7 days) and after (3 days) each treatment. Results-Compared with baseline data, arterial blood pressure decreased significantly both during and after tramadol-ketamine treatment but not with tramadol alone. Forelimb off-loading frequency significantly decreased during the first 3 days of treatment with tramadol only, returning to baseline frequency thereafter. The addition of ketamine to tramadol treatment reduced off-loading frequency both during and after treatment. Forelimb load did not change with tramadol alone but increased with tramadol-ketamine treatment. Plasma concentrations of tumor necrosis factor-α and thromboxane B2 were significantly reduced with tramadol-ketamine treatment but not with tramadol alone. Conclusions and Clinical Relevance-In horses with chronic laminitis, tramadol administration induced limited analgesia, but this effect was significantly enhanced by administration of subanesthetic doses of ketamine.

UR - http://www.scopus.com/inward/record.url?scp=84860331859&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860331859&partnerID=8YFLogxK

U2 - 10.2460/ajvr.73.5.610

DO - 10.2460/ajvr.73.5.610

M3 - Article

C2 - 22533391

AN - SCOPUS:84860331859

VL - 73

SP - 610

EP - 619

JO - American Journal of Veterinary Research

JF - American Journal of Veterinary Research

SN - 0002-9645

IS - 5

ER -