Abstract
It has been shown that epileptics have lower mean blood concentration of manganese than do controls but the cause of this abnormality has not been determined. In order to investigate the effects of seizures on manganese distribution in the body, rats were treated with kainic acid to produce spontaneous seizures which were quantitated for number and severity. Manganese, zinc, copper and iron concentrations were determined in blood, brain, liver, heart and kidney. Kainate-treated animals ate more food but gained less weight than controls. Liver and kidney manganese concentrations were significantly higher in kainate-treated animals than in controls. Blood manganese concentration showed a significant negative correlation with seizure index while heart manganese concentration showed a significant positive correlation with seizure index. None of the other trace elements showed a significant correlation between trace element concentration and seizure index in any of the tissues, although iron concentration was lower in brain and copper concentration was lower in kidney of kainate-treated animals than in their appropriate controls. These data show that manganese concentrations are generally elevated in tissues of kainate-treated animals. This increased manganese concentration may be related to the increased energy demand of these animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 223-227 |
| Number of pages | 5 |
| Journal | Neuroscience |
| Volume | 33 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1989 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Effect of kainate-induced seizures on tissue trace element concentrations in the rat. / Carl, G. F.; Critchfield, J. W.; Thompson, J. L.; McGinnis, L. S.; Wheeler, G. A.; Gallagher, B. B.; Holmes, G. L.; Hurley, L. S.; Keen, Carl L.
In: Neuroscience, Vol. 33, No. 1, 1989, p. 223-227.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of kainate-induced seizures on tissue trace element concentrations in the rat
AU - Carl, G. F.
AU - Critchfield, J. W.
AU - Thompson, J. L.
AU - McGinnis, L. S.
AU - Wheeler, G. A.
AU - Gallagher, B. B.
AU - Holmes, G. L.
AU - Hurley, L. S.
AU - Keen, Carl L
PY - 1989
Y1 - 1989
N2 - It has been shown that epileptics have lower mean blood concentration of manganese than do controls but the cause of this abnormality has not been determined. In order to investigate the effects of seizures on manganese distribution in the body, rats were treated with kainic acid to produce spontaneous seizures which were quantitated for number and severity. Manganese, zinc, copper and iron concentrations were determined in blood, brain, liver, heart and kidney. Kainate-treated animals ate more food but gained less weight than controls. Liver and kidney manganese concentrations were significantly higher in kainate-treated animals than in controls. Blood manganese concentration showed a significant negative correlation with seizure index while heart manganese concentration showed a significant positive correlation with seizure index. None of the other trace elements showed a significant correlation between trace element concentration and seizure index in any of the tissues, although iron concentration was lower in brain and copper concentration was lower in kidney of kainate-treated animals than in their appropriate controls. These data show that manganese concentrations are generally elevated in tissues of kainate-treated animals. This increased manganese concentration may be related to the increased energy demand of these animals.
AB - It has been shown that epileptics have lower mean blood concentration of manganese than do controls but the cause of this abnormality has not been determined. In order to investigate the effects of seizures on manganese distribution in the body, rats were treated with kainic acid to produce spontaneous seizures which were quantitated for number and severity. Manganese, zinc, copper and iron concentrations were determined in blood, brain, liver, heart and kidney. Kainate-treated animals ate more food but gained less weight than controls. Liver and kidney manganese concentrations were significantly higher in kainate-treated animals than in controls. Blood manganese concentration showed a significant negative correlation with seizure index while heart manganese concentration showed a significant positive correlation with seizure index. None of the other trace elements showed a significant correlation between trace element concentration and seizure index in any of the tissues, although iron concentration was lower in brain and copper concentration was lower in kidney of kainate-treated animals than in their appropriate controls. These data show that manganese concentrations are generally elevated in tissues of kainate-treated animals. This increased manganese concentration may be related to the increased energy demand of these animals.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024853406&partnerID=8YFLogxK
U2 - 10.1016/0306-4522(89)90323-0
DO - 10.1016/0306-4522(89)90323-0
M3 - Article
C2 - 2601857
AN - SCOPUS:0024853406
VL - 33
SP - 223
EP - 227
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
IS - 1
ER -