Effect of kainate-induced seizures on tissue trace element concentrations in the rat

G. F. Carl; J. W. Critchfield; J. L. Thompson; L. S. McGinnis; G. A. Wheeler; B. B. Gallagher; G. L. Holmes; L. S. Hurley; Carl L Keen

doi:10.1016/0306-4522(89)90323-0

Effect of kainate-induced seizures on tissue trace element concentrations in the rat

G. F. Carl, J. W. Critchfield, J. L. Thompson, L. S. McGinnis, G. A. Wheeler, B. B. Gallagher, G. L. Holmes, L. S. Hurley, Carl L Keen

Endocrinology, Diabetes, and Metabolism

Research output: Contribution to journal › Article

16 Scopus citations

Abstract

It has been shown that epileptics have lower mean blood concentration of manganese than do controls but the cause of this abnormality has not been determined. In order to investigate the effects of seizures on manganese distribution in the body, rats were treated with kainic acid to produce spontaneous seizures which were quantitated for number and severity. Manganese, zinc, copper and iron concentrations were determined in blood, brain, liver, heart and kidney. Kainate-treated animals ate more food but gained less weight than controls. Liver and kidney manganese concentrations were significantly higher in kainate-treated animals than in controls. Blood manganese concentration showed a significant negative correlation with seizure index while heart manganese concentration showed a significant positive correlation with seizure index. None of the other trace elements showed a significant correlation between trace element concentration and seizure index in any of the tissues, although iron concentration was lower in brain and copper concentration was lower in kidney of kainate-treated animals than in their appropriate controls. These data show that manganese concentrations are generally elevated in tissues of kainate-treated animals. This increased manganese concentration may be related to the increased energy demand of these animals.

Original language	English (US)
Pages (from-to)	223-227
Number of pages	5
Journal	Neuroscience
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/0306-4522(89)90323-0
State	Published - 1989

ASJC Scopus subject areas

Neuroscience(all)

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Carl, G. F., Critchfield, J. W., Thompson, J. L., McGinnis, L. S., Wheeler, G. A., Gallagher, B. B., Holmes, G. L., Hurley, L. S., & Keen, C. L. (1989). Effect of kainate-induced seizures on tissue trace element concentrations in the rat. Neuroscience, 33(1), 223-227. https://doi.org/10.1016/0306-4522(89)90323-0

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title = "Effect of kainate-induced seizures on tissue trace element concentrations in the rat",

abstract = "It has been shown that epileptics have lower mean blood concentration of manganese than do controls but the cause of this abnormality has not been determined. In order to investigate the effects of seizures on manganese distribution in the body, rats were treated with kainic acid to produce spontaneous seizures which were quantitated for number and severity. Manganese, zinc, copper and iron concentrations were determined in blood, brain, liver, heart and kidney. Kainate-treated animals ate more food but gained less weight than controls. Liver and kidney manganese concentrations were significantly higher in kainate-treated animals than in controls. Blood manganese concentration showed a significant negative correlation with seizure index while heart manganese concentration showed a significant positive correlation with seizure index. None of the other trace elements showed a significant correlation between trace element concentration and seizure index in any of the tissues, although iron concentration was lower in brain and copper concentration was lower in kidney of kainate-treated animals than in their appropriate controls. These data show that manganese concentrations are generally elevated in tissues of kainate-treated animals. This increased manganese concentration may be related to the increased energy demand of these animals.",

author = "Carl, {G. F.} and Critchfield, {J. W.} and Thompson, {J. L.} and McGinnis, {L. S.} and Wheeler, {G. A.} and Gallagher, {B. B.} and Holmes, {G. L.} and Hurley, {L. S.} and Keen, {Carl L}",

year = "1989",

doi = "10.1016/0306-4522(89)90323-0",

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AU - Carl, G. F.

AU - Critchfield, J. W.

AU - Thompson, J. L.

AU - McGinnis, L. S.

AU - Wheeler, G. A.

AU - Gallagher, B. B.

AU - Holmes, G. L.

AU - Hurley, L. S.

AU - Keen, Carl L

PY - 1989

Y1 - 1989

N2 - It has been shown that epileptics have lower mean blood concentration of manganese than do controls but the cause of this abnormality has not been determined. In order to investigate the effects of seizures on manganese distribution in the body, rats were treated with kainic acid to produce spontaneous seizures which were quantitated for number and severity. Manganese, zinc, copper and iron concentrations were determined in blood, brain, liver, heart and kidney. Kainate-treated animals ate more food but gained less weight than controls. Liver and kidney manganese concentrations were significantly higher in kainate-treated animals than in controls. Blood manganese concentration showed a significant negative correlation with seizure index while heart manganese concentration showed a significant positive correlation with seizure index. None of the other trace elements showed a significant correlation between trace element concentration and seizure index in any of the tissues, although iron concentration was lower in brain and copper concentration was lower in kidney of kainate-treated animals than in their appropriate controls. These data show that manganese concentrations are generally elevated in tissues of kainate-treated animals. This increased manganese concentration may be related to the increased energy demand of these animals.

AB - It has been shown that epileptics have lower mean blood concentration of manganese than do controls but the cause of this abnormality has not been determined. In order to investigate the effects of seizures on manganese distribution in the body, rats were treated with kainic acid to produce spontaneous seizures which were quantitated for number and severity. Manganese, zinc, copper and iron concentrations were determined in blood, brain, liver, heart and kidney. Kainate-treated animals ate more food but gained less weight than controls. Liver and kidney manganese concentrations were significantly higher in kainate-treated animals than in controls. Blood manganese concentration showed a significant negative correlation with seizure index while heart manganese concentration showed a significant positive correlation with seizure index. None of the other trace elements showed a significant correlation between trace element concentration and seizure index in any of the tissues, although iron concentration was lower in brain and copper concentration was lower in kidney of kainate-treated animals than in their appropriate controls. These data show that manganese concentrations are generally elevated in tissues of kainate-treated animals. This increased manganese concentration may be related to the increased energy demand of these animals.

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