Effect of intravitreal dexamethasone in treatment of pneumococcal endophthalmitis in rabbits

Susanna Soon Chun Park, N. Samiy, K. Ruoff, D. J. D'Amico, A. S. Baker

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Purpose: To investigate whether corticosteroid therapy would decrease the inflammation and tissue damage associated with pneumococcal endophthalmitis. Methods: Albino rabbits were injected intravitreally with 1000 live organisms of Streptococcus pneumoniae and randomized after 24 hours to treatment with intravitreal vancomycin hydrochloride alone (n=10), combination intravitreal vancomycin and intravitreal dexamethasone (n=10), or no treatment (n=10). After 2 weeks, the eyes were examined clinically and enucleated for histopathologic examination. Results: Eyes treated with vancomycin and dexamethasone had significantly less intraocular inflammation and more preservation of retinal tissue than untreated eyes or eyes treated with vancomycin alone (P<.05, Fisher's exact test). Untreated and vancomycin- treated eyes were indistinguishable on clinical and histologic examination. Marked anterior and posterior segment inflammation with total retinal necrosis was noted in eyes from both groups. Conclusion: Intravitreal corticosteroid therapy may play an important role in minimizing the inflammation and tissue damage associated with pneumococcal endophthalmitis.

Original languageEnglish (US)
Pages (from-to)1324-1329
Number of pages6
JournalArchives of Ophthalmology
Volume113
Issue number10
StatePublished - 1995
Externally publishedYes

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Endophthalmitis
Dexamethasone
Vancomycin
Rabbits
Inflammation
Adrenal Cortex Hormones
Therapeutics
Play Therapy
Tissue Preservation
Streptococcus pneumoniae
Necrosis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Effect of intravitreal dexamethasone in treatment of pneumococcal endophthalmitis in rabbits. / Park, Susanna Soon Chun; Samiy, N.; Ruoff, K.; D'Amico, D. J.; Baker, A. S.

In: Archives of Ophthalmology, Vol. 113, No. 10, 1995, p. 1324-1329.

Research output: Contribution to journalArticle

Park, SSC, Samiy, N, Ruoff, K, D'Amico, DJ & Baker, AS 1995, 'Effect of intravitreal dexamethasone in treatment of pneumococcal endophthalmitis in rabbits', Archives of Ophthalmology, vol. 113, no. 10, pp. 1324-1329.
Park, Susanna Soon Chun ; Samiy, N. ; Ruoff, K. ; D'Amico, D. J. ; Baker, A. S. / Effect of intravitreal dexamethasone in treatment of pneumococcal endophthalmitis in rabbits. In: Archives of Ophthalmology. 1995 ; Vol. 113, No. 10. pp. 1324-1329.
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