Effect of intravenous silica on the course of Nocardia asteroides pneumonia

Claire Pomeroy, G. A. Filice

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Silica, a known toxin of mononuclear phagocytes, was administered intravenously to mice during Nocardia asteroides pneumonia. Mice that received silica had a sevenfold decrease in the number of peripheral blood monocytes and developed more severe N. asteroides pneumonia than control mice. Lung histology in mice that received silica resembled that of mice with impaired cell-mediated immunity. These results are most consisent with the explanation that silica injures blood monocytes and impaires their contributions to pulmonary host defense.

Original languageEnglish (US)
Pages (from-to)2507-2511
Number of pages5
JournalInfection and Immunity
Issue number9
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


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