Effect of intravenous silica on the course of Nocardia asteroides pneumonia

Claire Pomeroy, G. A. Filice

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Silica, a known toxin of mononuclear phagocytes, was administered intravenously to mice during Nocardia asteroides pneumonia. Mice that received silica had a sevenfold decrease in the number of peripheral blood monocytes and developed more severe N. asteroides pneumonia than control mice. Lung histology in mice that received silica resembled that of mice with impaired cell-mediated immunity. These results are most consisent with the explanation that silica injures blood monocytes and impaires their contributions to pulmonary host defense.

Original languageEnglish (US)
Pages (from-to)2507-2511
Number of pages5
JournalInfection and Immunity
Volume56
Issue number9
StatePublished - 1988
Externally publishedYes

Fingerprint

Nocardia asteroides
Silicon Dioxide
Pneumonia
Monocytes
Lung
Phagocytes
Cellular Immunity
Histology

ASJC Scopus subject areas

  • Immunology

Cite this

Effect of intravenous silica on the course of Nocardia asteroides pneumonia. / Pomeroy, Claire; Filice, G. A.

In: Infection and Immunity, Vol. 56, No. 9, 1988, p. 2507-2511.

Research output: Contribution to journalArticle

Pomeroy, C & Filice, GA 1988, 'Effect of intravenous silica on the course of Nocardia asteroides pneumonia', Infection and Immunity, vol. 56, no. 9, pp. 2507-2511.
Pomeroy, Claire ; Filice, G. A. / Effect of intravenous silica on the course of Nocardia asteroides pneumonia. In: Infection and Immunity. 1988 ; Vol. 56, No. 9. pp. 2507-2511.
@article{e5c702190dec4e01afd31c7095151998,
title = "Effect of intravenous silica on the course of Nocardia asteroides pneumonia",
abstract = "Silica, a known toxin of mononuclear phagocytes, was administered intravenously to mice during Nocardia asteroides pneumonia. Mice that received silica had a sevenfold decrease in the number of peripheral blood monocytes and developed more severe N. asteroides pneumonia than control mice. Lung histology in mice that received silica resembled that of mice with impaired cell-mediated immunity. These results are most consisent with the explanation that silica injures blood monocytes and impaires their contributions to pulmonary host defense.",
author = "Claire Pomeroy and Filice, {G. A.}",
year = "1988",
language = "English (US)",
volume = "56",
pages = "2507--2511",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "9",

}

TY - JOUR

T1 - Effect of intravenous silica on the course of Nocardia asteroides pneumonia

AU - Pomeroy, Claire

AU - Filice, G. A.

PY - 1988

Y1 - 1988

N2 - Silica, a known toxin of mononuclear phagocytes, was administered intravenously to mice during Nocardia asteroides pneumonia. Mice that received silica had a sevenfold decrease in the number of peripheral blood monocytes and developed more severe N. asteroides pneumonia than control mice. Lung histology in mice that received silica resembled that of mice with impaired cell-mediated immunity. These results are most consisent with the explanation that silica injures blood monocytes and impaires their contributions to pulmonary host defense.

AB - Silica, a known toxin of mononuclear phagocytes, was administered intravenously to mice during Nocardia asteroides pneumonia. Mice that received silica had a sevenfold decrease in the number of peripheral blood monocytes and developed more severe N. asteroides pneumonia than control mice. Lung histology in mice that received silica resembled that of mice with impaired cell-mediated immunity. These results are most consisent with the explanation that silica injures blood monocytes and impaires their contributions to pulmonary host defense.

UR - http://www.scopus.com/inward/record.url?scp=0023688894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023688894&partnerID=8YFLogxK

M3 - Article

C2 - 3045004

AN - SCOPUS:0023688894

VL - 56

SP - 2507

EP - 2511

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 9

ER -