Effect of intracameral administration of carbachol on the postoperative increase in intraocular pressure in dogs undergoing cataract extraction

Charles M. Stuhr, Paul E. Miller, Christopher J Murphy, James V. Schoster, Chester B. Thomas

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective-To determine whether intracameral injection of carbachol at the completion of phacoemulsification in dogs would prevent the increase in intraocular pressure (IOP) that can develop during the first 24 hours after surgery. Design-Randomized controlled trial. Animals-32 adult dogs undergoing elective unilateral or bilateral phacoemulsification. Procedure-Dogs were randomly assigned to 1 of 4 groups within 8 dogs/group: phacoemulsification and intracameral administration of 0.5 ml of 0.01% carbachol at the end of surgery; phacoemulsification, intraocular lens implantation, and intracameral administration of 0.5 ml of 0.01% carbachol; phacoemulsification and intracameral administration of 0.5 ml of balanced salt solution; and phacoemulsification; intraocular lens implantation, and intracameral administration of 0.5 ml of balanced salt solution. Intraocular pressure was measured at 3 and 6 hours and the morning after surgery. Aqueous flare was also measured 6 hours and the morning after surgery. Results-None of the dogs treated with carbachol developed postoperative ocular hypertension (ie, IOP > 27 mm of Hg), whereas 12 of 16 control dogs had ocular hypertension 3 hours after surgery. Intraocular pressure 3 hours after surgery was not significantly with phacoemulsification time or phacoemulsification power or with whether the dog received an intraocular lens implant. Severity of aqueous flare was similar for treated and control dogs. Clinical Implications-Results suggested that intracameral administration of 0.01% carbachol at the end of surgery was a safe and efficacious method of preventing the postoperative increase in IOP associated with phacoemulsification in dogs.

Original languageEnglish (US)
Pages (from-to)1885-1888
Number of pages4
JournalJournal of the American Veterinary Medical Association
Volume212
Issue number12
StatePublished - Jun 15 1998
Externally publishedYes

Fingerprint

carbachol
Phacoemulsification
Cataract Extraction
cataract
Carbachol
Intraocular Pressure
Dogs
surgery
dogs
Ocular Hypertension
Intraocular Lens Implantation
Aqueous Humor
Lens
hypertension
Salts
eyes
salts
prostheses
Intraocular Lenses
Randomized Controlled Trials

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effect of intracameral administration of carbachol on the postoperative increase in intraocular pressure in dogs undergoing cataract extraction. / Stuhr, Charles M.; Miller, Paul E.; Murphy, Christopher J; Schoster, James V.; Thomas, Chester B.

In: Journal of the American Veterinary Medical Association, Vol. 212, No. 12, 15.06.1998, p. 1885-1888.

Research output: Contribution to journalArticle

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abstract = "Objective-To determine whether intracameral injection of carbachol at the completion of phacoemulsification in dogs would prevent the increase in intraocular pressure (IOP) that can develop during the first 24 hours after surgery. Design-Randomized controlled trial. Animals-32 adult dogs undergoing elective unilateral or bilateral phacoemulsification. Procedure-Dogs were randomly assigned to 1 of 4 groups within 8 dogs/group: phacoemulsification and intracameral administration of 0.5 ml of 0.01{\%} carbachol at the end of surgery; phacoemulsification, intraocular lens implantation, and intracameral administration of 0.5 ml of 0.01{\%} carbachol; phacoemulsification and intracameral administration of 0.5 ml of balanced salt solution; and phacoemulsification; intraocular lens implantation, and intracameral administration of 0.5 ml of balanced salt solution. Intraocular pressure was measured at 3 and 6 hours and the morning after surgery. Aqueous flare was also measured 6 hours and the morning after surgery. Results-None of the dogs treated with carbachol developed postoperative ocular hypertension (ie, IOP > 27 mm of Hg), whereas 12 of 16 control dogs had ocular hypertension 3 hours after surgery. Intraocular pressure 3 hours after surgery was not significantly with phacoemulsification time or phacoemulsification power or with whether the dog received an intraocular lens implant. Severity of aqueous flare was similar for treated and control dogs. Clinical Implications-Results suggested that intracameral administration of 0.01{\%} carbachol at the end of surgery was a safe and efficacious method of preventing the postoperative increase in IOP associated with phacoemulsification in dogs.",
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