Abstract
A number of investigators have reported on the clinically significant relationship between diabetes mellitus and impaired wound healing. Diabetic patients have an increased frequency of infection, delayed scar formation, and poor bony union. Investigations completed in our laboratory have demonstrated that insulin-like growth factor type 1 (IGF-1), a somatomedin C, has shown promise for accelerating bony repair. The purpose of this study was to examine the effects of recombinant IGF-1 on standardized, critical-size calvarial defects in 25 adult, male streptozocin-induced diabetic rats. From our study, it appears that IGF-1 exerts a potentiating effect on the repair of bony defects in diabetes-induced rats.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 218-223 |
| Number of pages | 6 |
| Journal | Journal of Craniofacial Surgery |
| Volume | 6 |
| Issue number | 3 |
| State | Published - 1995 |
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Keywords
- Bone repair
- Critical-size defects
- Diabetes
- Growth factors
- Impaired wound healing
ASJC Scopus subject areas
- Surgery
Cite this
Effect of insulin-like growth factor type 1 on critical-size defects in diabetic rats. / Thaller, S. R.; Lee, T. J.; Armstrong, M.; Tesluk, H.; Stern, J. S.
In: Journal of Craniofacial Surgery, Vol. 6, No. 3, 1995, p. 218-223.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of insulin-like growth factor type 1 on critical-size defects in diabetic rats
AU - Thaller, S. R.
AU - Lee, T. J.
AU - Armstrong, M.
AU - Tesluk, H.
AU - Stern, J. S.
PY - 1995
Y1 - 1995
N2 - A number of investigators have reported on the clinically significant relationship between diabetes mellitus and impaired wound healing. Diabetic patients have an increased frequency of infection, delayed scar formation, and poor bony union. Investigations completed in our laboratory have demonstrated that insulin-like growth factor type 1 (IGF-1), a somatomedin C, has shown promise for accelerating bony repair. The purpose of this study was to examine the effects of recombinant IGF-1 on standardized, critical-size calvarial defects in 25 adult, male streptozocin-induced diabetic rats. From our study, it appears that IGF-1 exerts a potentiating effect on the repair of bony defects in diabetes-induced rats.
AB - A number of investigators have reported on the clinically significant relationship between diabetes mellitus and impaired wound healing. Diabetic patients have an increased frequency of infection, delayed scar formation, and poor bony union. Investigations completed in our laboratory have demonstrated that insulin-like growth factor type 1 (IGF-1), a somatomedin C, has shown promise for accelerating bony repair. The purpose of this study was to examine the effects of recombinant IGF-1 on standardized, critical-size calvarial defects in 25 adult, male streptozocin-induced diabetic rats. From our study, it appears that IGF-1 exerts a potentiating effect on the repair of bony defects in diabetes-induced rats.
KW - Bone repair
KW - Critical-size defects
KW - Diabetes
KW - Growth factors
KW - Impaired wound healing
UR - http://www.scopus.com/inward/record.url?scp=0029063280&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029063280&partnerID=8YFLogxK
M3 - Article
C2 - 9020692
AN - SCOPUS:0029063280
VL - 6
SP - 218
EP - 223
JO - Journal of Craniofacial Surgery
JF - Journal of Craniofacial Surgery
SN - 1049-2275
IS - 3
ER -