Effect of insulin-like growth factor type 1 on critical-size defects in diabetic rats

S. R. Thaller; T. J. Lee; M. Armstrong; H. Tesluk; J. S. Stern

Effect of insulin-like growth factor type 1 on critical-size defects in diabetic rats

S. R. Thaller, T. J. Lee, M. Armstrong, H. Tesluk, J. S. Stern

Endocrinology, Diabetes, and Metabolism

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A number of investigators have reported on the clinically significant relationship between diabetes mellitus and impaired wound healing. Diabetic patients have an increased frequency of infection, delayed scar formation, and poor bony union. Investigations completed in our laboratory have demonstrated that insulin-like growth factor type 1 (IGF-1), a somatomedin C, has shown promise for accelerating bony repair. The purpose of this study was to examine the effects of recombinant IGF-1 on standardized, critical-size calvarial defects in 25 adult, male streptozocin-induced diabetic rats. From our study, it appears that IGF-1 exerts a potentiating effect on the repair of bony defects in diabetes-induced rats.

Original language	English (US)
Pages (from-to)	218-223
Number of pages	6
Journal	Journal of Craniofacial Surgery
Volume	6
Issue number	3
State	Published - 1995

Keywords

Bone repair
Critical-size defects
Diabetes
Growth factors
Impaired wound healing

ASJC Scopus subject areas

Surgery

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