Effect of in-painting on cortical thickness measurements in multiple sclerosis

A large cohort study

Koushik A. Govindarajan, Sushmita Datta, Khader M. Hasan, Sangbum Choi, Mohammad H. Rahbar, Stacey S. Cofield, Gary R. Cutter, Fred D. Lublin, Jerry S. Wolinsky, Ponnada A. Narayana, F. Nelson, I. Vainrub, R. He, B. Gates, K. Ton, M. Agius, K. Bashir, R. Baumhefner, G. Birnbaum, G. Blevins & 80 others R. Bomprezzi, A. Boster, T. Brown, J. Burkholder, A. Camac, D. Campagnolo, J. Carter, B. Cohen, J. Cooper, J. Corboy, A. Cross, L. Dewitt, J. Dunn, K. Edwards, E. Eggenberger, J. English, W. Felton, P. Fodor, C. Ford, M. Freedman, S. Galetta, G. Garmany, A. Goodman, M. Gottesman, C. Gottschalk, M. Gruental, M. Gudesblatt, R. Hamill, J. Herbert, R. Holub, W. Honeycutt, B. Hughes, G. Hutton, D. Jacobs, K. Johnson, L. Kasper, J. Kattah, M. Kaufman, M. Keegan, O. Khan, B. Khatri, M. Kita, B. Koffman, E. Lallana, N. Lava, J. Lindsey, P. Loge, S. Lynch, F. McGee, L. Mejico, L. Metz, P. O'Connor, K. Pandey, H. Panitch, J. Preiningerova, K. Rammohan, C. Riley, P. Riskind, L. Rolak, W. Royal, S. Scarberry, A. Schulman, T. Scott, C. Sheppard, W. Sheremata, L. Stone, W. Stuart, S. Subramaniam, V. Thadani, F. Thomas, B. Thrower, M. Tullman, A. Turel, T. Vollmer, S. Waldman, B. Weinstock-Guttman, J. Wendt, R. Williams, D. Wynn, M. Yeung

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A comprehensive analysis of the effect of lesion in-painting on the estimation of cortical thickness using magnetic resonance imaging was performed on a large cohort of 918 relapsing-remitting multiple sclerosis patients who participated in a phase III multicenter clinical trial. An automatic lesion in-painting algorithm was developed and implemented. Cortical thickness was measured using the FreeSurfer pipeline with and without in-painting. The effect of in-painting was evaluated using FreeSurfer's paired analysis pipeline. Multivariate regression analysis was also performed with field strength and lesion load as additional factors. Overall, the estimated cortical thickness was different with in-painting than without. The effect of in-painting was observed to be region dependent, more significant in the left hemisphere compared to the right, was more prominent at 1.5 T relative to 3 T, and was greater at higher lesion volumes. Our results show that even for data acquired at 1.5 T in patients with high lesion load, the mean cortical thickness difference with and without in-painting is ~2%. Based on these results, it appears that in-painting has only a small effect on the estimated regional and global cortical thickness.

Original languageEnglish (US)
Pages (from-to)3749-3760
Number of pages12
JournalHuman Brain Mapping
Volume36
Issue number10
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Fingerprint

Paintings
Multiple Sclerosis
Cohort Studies
Relapsing-Remitting Multiple Sclerosis
Phase III Clinical Trials
Multicenter Studies
Multivariate Analysis
Regression Analysis
Magnetic Resonance Imaging

Keywords

  • Cortical thickness
  • FreeSurfer
  • Lesion in-painting
  • Multiple sclerosis
  • Multiple sclerosis lesions

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Govindarajan, K. A., Datta, S., Hasan, K. M., Choi, S., Rahbar, M. H., Cofield, S. S., ... Yeung, M. (2015). Effect of in-painting on cortical thickness measurements in multiple sclerosis: A large cohort study. Human Brain Mapping, 36(10), 3749-3760. https://doi.org/10.1002/hbm.22875

Effect of in-painting on cortical thickness measurements in multiple sclerosis : A large cohort study. / Govindarajan, Koushik A.; Datta, Sushmita; Hasan, Khader M.; Choi, Sangbum; Rahbar, Mohammad H.; Cofield, Stacey S.; Cutter, Gary R.; Lublin, Fred D.; Wolinsky, Jerry S.; Narayana, Ponnada A.; Nelson, F.; Vainrub, I.; He, R.; Gates, B.; Ton, K.; Agius, M.; Bashir, K.; Baumhefner, R.; Birnbaum, G.; Blevins, G.; Bomprezzi, R.; Boster, A.; Brown, T.; Burkholder, J.; Camac, A.; Campagnolo, D.; Carter, J.; Cohen, B.; Cooper, J.; Corboy, J.; Cross, A.; Dewitt, L.; Dunn, J.; Edwards, K.; Eggenberger, E.; English, J.; Felton, W.; Fodor, P.; Ford, C.; Freedman, M.; Galetta, S.; Garmany, G.; Goodman, A.; Gottesman, M.; Gottschalk, C.; Gruental, M.; Gudesblatt, M.; Hamill, R.; Herbert, J.; Holub, R.; Honeycutt, W.; Hughes, B.; Hutton, G.; Jacobs, D.; Johnson, K.; Kasper, L.; Kattah, J.; Kaufman, M.; Keegan, M.; Khan, O.; Khatri, B.; Kita, M.; Koffman, B.; Lallana, E.; Lava, N.; Lindsey, J.; Loge, P.; Lynch, S.; McGee, F.; Mejico, L.; Metz, L.; O'Connor, P.; Pandey, K.; Panitch, H.; Preiningerova, J.; Rammohan, K.; Riley, C.; Riskind, P.; Rolak, L.; Royal, W.; Scarberry, S.; Schulman, A.; Scott, T.; Sheppard, C.; Sheremata, W.; Stone, L.; Stuart, W.; Subramaniam, S.; Thadani, V.; Thomas, F.; Thrower, B.; Tullman, M.; Turel, A.; Vollmer, T.; Waldman, S.; Weinstock-Guttman, B.; Wendt, J.; Williams, R.; Wynn, D.; Yeung, M.

In: Human Brain Mapping, Vol. 36, No. 10, 01.10.2015, p. 3749-3760.

Research output: Contribution to journalArticle

Govindarajan, KA, Datta, S, Hasan, KM, Choi, S, Rahbar, MH, Cofield, SS, Cutter, GR, Lublin, FD, Wolinsky, JS, Narayana, PA, Nelson, F, Vainrub, I, He, R, Gates, B, Ton, K, Agius, M, Bashir, K, Baumhefner, R, Birnbaum, G, Blevins, G, Bomprezzi, R, Boster, A, Brown, T, Burkholder, J, Camac, A, Campagnolo, D, Carter, J, Cohen, B, Cooper, J, Corboy, J, Cross, A, Dewitt, L, Dunn, J, Edwards, K, Eggenberger, E, English, J, Felton, W, Fodor, P, Ford, C, Freedman, M, Galetta, S, Garmany, G, Goodman, A, Gottesman, M, Gottschalk, C, Gruental, M, Gudesblatt, M, Hamill, R, Herbert, J, Holub, R, Honeycutt, W, Hughes, B, Hutton, G, Jacobs, D, Johnson, K, Kasper, L, Kattah, J, Kaufman, M, Keegan, M, Khan, O, Khatri, B, Kita, M, Koffman, B, Lallana, E, Lava, N, Lindsey, J, Loge, P, Lynch, S, McGee, F, Mejico, L, Metz, L, O'Connor, P, Pandey, K, Panitch, H, Preiningerova, J, Rammohan, K, Riley, C, Riskind, P, Rolak, L, Royal, W, Scarberry, S, Schulman, A, Scott, T, Sheppard, C, Sheremata, W, Stone, L, Stuart, W, Subramaniam, S, Thadani, V, Thomas, F, Thrower, B, Tullman, M, Turel, A, Vollmer, T, Waldman, S, Weinstock-Guttman, B, Wendt, J, Williams, R, Wynn, D & Yeung, M 2015, 'Effect of in-painting on cortical thickness measurements in multiple sclerosis: A large cohort study', Human Brain Mapping, vol. 36, no. 10, pp. 3749-3760. https://doi.org/10.1002/hbm.22875
Govindarajan KA, Datta S, Hasan KM, Choi S, Rahbar MH, Cofield SS et al. Effect of in-painting on cortical thickness measurements in multiple sclerosis: A large cohort study. Human Brain Mapping. 2015 Oct 1;36(10):3749-3760. https://doi.org/10.1002/hbm.22875
Govindarajan, Koushik A. ; Datta, Sushmita ; Hasan, Khader M. ; Choi, Sangbum ; Rahbar, Mohammad H. ; Cofield, Stacey S. ; Cutter, Gary R. ; Lublin, Fred D. ; Wolinsky, Jerry S. ; Narayana, Ponnada A. ; Nelson, F. ; Vainrub, I. ; He, R. ; Gates, B. ; Ton, K. ; Agius, M. ; Bashir, K. ; Baumhefner, R. ; Birnbaum, G. ; Blevins, G. ; Bomprezzi, R. ; Boster, A. ; Brown, T. ; Burkholder, J. ; Camac, A. ; Campagnolo, D. ; Carter, J. ; Cohen, B. ; Cooper, J. ; Corboy, J. ; Cross, A. ; Dewitt, L. ; Dunn, J. ; Edwards, K. ; Eggenberger, E. ; English, J. ; Felton, W. ; Fodor, P. ; Ford, C. ; Freedman, M. ; Galetta, S. ; Garmany, G. ; Goodman, A. ; Gottesman, M. ; Gottschalk, C. ; Gruental, M. ; Gudesblatt, M. ; Hamill, R. ; Herbert, J. ; Holub, R. ; Honeycutt, W. ; Hughes, B. ; Hutton, G. ; Jacobs, D. ; Johnson, K. ; Kasper, L. ; Kattah, J. ; Kaufman, M. ; Keegan, M. ; Khan, O. ; Khatri, B. ; Kita, M. ; Koffman, B. ; Lallana, E. ; Lava, N. ; Lindsey, J. ; Loge, P. ; Lynch, S. ; McGee, F. ; Mejico, L. ; Metz, L. ; O'Connor, P. ; Pandey, K. ; Panitch, H. ; Preiningerova, J. ; Rammohan, K. ; Riley, C. ; Riskind, P. ; Rolak, L. ; Royal, W. ; Scarberry, S. ; Schulman, A. ; Scott, T. ; Sheppard, C. ; Sheremata, W. ; Stone, L. ; Stuart, W. ; Subramaniam, S. ; Thadani, V. ; Thomas, F. ; Thrower, B. ; Tullman, M. ; Turel, A. ; Vollmer, T. ; Waldman, S. ; Weinstock-Guttman, B. ; Wendt, J. ; Williams, R. ; Wynn, D. ; Yeung, M. / Effect of in-painting on cortical thickness measurements in multiple sclerosis : A large cohort study. In: Human Brain Mapping. 2015 ; Vol. 36, No. 10. pp. 3749-3760.
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abstract = "A comprehensive analysis of the effect of lesion in-painting on the estimation of cortical thickness using magnetic resonance imaging was performed on a large cohort of 918 relapsing-remitting multiple sclerosis patients who participated in a phase III multicenter clinical trial. An automatic lesion in-painting algorithm was developed and implemented. Cortical thickness was measured using the FreeSurfer pipeline with and without in-painting. The effect of in-painting was evaluated using FreeSurfer's paired analysis pipeline. Multivariate regression analysis was also performed with field strength and lesion load as additional factors. Overall, the estimated cortical thickness was different with in-painting than without. The effect of in-painting was observed to be region dependent, more significant in the left hemisphere compared to the right, was more prominent at 1.5 T relative to 3 T, and was greater at higher lesion volumes. Our results show that even for data acquired at 1.5 T in patients with high lesion load, the mean cortical thickness difference with and without in-painting is ~2{\%}. Based on these results, it appears that in-painting has only a small effect on the estimated regional and global cortical thickness.",
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TY - JOUR

T1 - Effect of in-painting on cortical thickness measurements in multiple sclerosis

T2 - A large cohort study

AU - Govindarajan, Koushik A.

AU - Datta, Sushmita

AU - Hasan, Khader M.

AU - Choi, Sangbum

AU - Rahbar, Mohammad H.

AU - Cofield, Stacey S.

AU - Cutter, Gary R.

AU - Lublin, Fred D.

AU - Wolinsky, Jerry S.

AU - Narayana, Ponnada A.

AU - Nelson, F.

AU - Vainrub, I.

AU - He, R.

AU - Gates, B.

AU - Ton, K.

AU - Agius, M.

AU - Bashir, K.

AU - Baumhefner, R.

AU - Birnbaum, G.

AU - Blevins, G.

AU - Bomprezzi, R.

AU - Boster, A.

AU - Brown, T.

AU - Burkholder, J.

AU - Camac, A.

AU - Campagnolo, D.

AU - Carter, J.

AU - Cohen, B.

AU - Cooper, J.

AU - Corboy, J.

AU - Cross, A.

AU - Dewitt, L.

AU - Dunn, J.

AU - Edwards, K.

AU - Eggenberger, E.

AU - English, J.

AU - Felton, W.

AU - Fodor, P.

AU - Ford, C.

AU - Freedman, M.

AU - Galetta, S.

AU - Garmany, G.

AU - Goodman, A.

AU - Gottesman, M.

AU - Gottschalk, C.

AU - Gruental, M.

AU - Gudesblatt, M.

AU - Hamill, R.

AU - Herbert, J.

AU - Holub, R.

AU - Honeycutt, W.

AU - Hughes, B.

AU - Hutton, G.

AU - Jacobs, D.

AU - Johnson, K.

AU - Kasper, L.

AU - Kattah, J.

AU - Kaufman, M.

AU - Keegan, M.

AU - Khan, O.

AU - Khatri, B.

AU - Kita, M.

AU - Koffman, B.

AU - Lallana, E.

AU - Lava, N.

AU - Lindsey, J.

AU - Loge, P.

AU - Lynch, S.

AU - McGee, F.

AU - Mejico, L.

AU - Metz, L.

AU - O'Connor, P.

AU - Pandey, K.

AU - Panitch, H.

AU - Preiningerova, J.

AU - Rammohan, K.

AU - Riley, C.

AU - Riskind, P.

AU - Rolak, L.

AU - Royal, W.

AU - Scarberry, S.

AU - Schulman, A.

AU - Scott, T.

AU - Sheppard, C.

AU - Sheremata, W.

AU - Stone, L.

AU - Stuart, W.

AU - Subramaniam, S.

AU - Thadani, V.

AU - Thomas, F.

AU - Thrower, B.

AU - Tullman, M.

AU - Turel, A.

AU - Vollmer, T.

AU - Waldman, S.

AU - Weinstock-Guttman, B.

AU - Wendt, J.

AU - Williams, R.

AU - Wynn, D.

AU - Yeung, M.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - A comprehensive analysis of the effect of lesion in-painting on the estimation of cortical thickness using magnetic resonance imaging was performed on a large cohort of 918 relapsing-remitting multiple sclerosis patients who participated in a phase III multicenter clinical trial. An automatic lesion in-painting algorithm was developed and implemented. Cortical thickness was measured using the FreeSurfer pipeline with and without in-painting. The effect of in-painting was evaluated using FreeSurfer's paired analysis pipeline. Multivariate regression analysis was also performed with field strength and lesion load as additional factors. Overall, the estimated cortical thickness was different with in-painting than without. The effect of in-painting was observed to be region dependent, more significant in the left hemisphere compared to the right, was more prominent at 1.5 T relative to 3 T, and was greater at higher lesion volumes. Our results show that even for data acquired at 1.5 T in patients with high lesion load, the mean cortical thickness difference with and without in-painting is ~2%. Based on these results, it appears that in-painting has only a small effect on the estimated regional and global cortical thickness.

AB - A comprehensive analysis of the effect of lesion in-painting on the estimation of cortical thickness using magnetic resonance imaging was performed on a large cohort of 918 relapsing-remitting multiple sclerosis patients who participated in a phase III multicenter clinical trial. An automatic lesion in-painting algorithm was developed and implemented. Cortical thickness was measured using the FreeSurfer pipeline with and without in-painting. The effect of in-painting was evaluated using FreeSurfer's paired analysis pipeline. Multivariate regression analysis was also performed with field strength and lesion load as additional factors. Overall, the estimated cortical thickness was different with in-painting than without. The effect of in-painting was observed to be region dependent, more significant in the left hemisphere compared to the right, was more prominent at 1.5 T relative to 3 T, and was greater at higher lesion volumes. Our results show that even for data acquired at 1.5 T in patients with high lesion load, the mean cortical thickness difference with and without in-painting is ~2%. Based on these results, it appears that in-painting has only a small effect on the estimated regional and global cortical thickness.

KW - Cortical thickness

KW - FreeSurfer

KW - Lesion in-painting

KW - Multiple sclerosis

KW - Multiple sclerosis lesions

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