Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis

H. B. Greenberg, Richard B Pollard, L. I. Lutwick, P. B. Gregory, W. S. Robinson, T. C. Merigan

Research output: Contribution to journalArticle

411 Citations (Scopus)

Abstract

Four patients with chronic hepatitis B infection and chronic active hepatitis were treated with human leukocyte interferon. Three of them had consistently elevated levels of circulating Dane particle markers, including Dane particle associated DNA polymerase activity, hepatitis B core antigen and Dane particle associated DNA. Parenteral interferon administration at a dosage between 6.0 x 10 3 and 17 x 10 4 U per kilogram per day was associated with a rapid and reproducible fall in all Dane particle markers in the three patients. The suppressive effect was transient when the interferon was given for 10 days or less but appeared to be more permanent when administration was prolonged for a month or more. In addition, long term interferon therapy was associated with a marked fall in hepatitis B surface antigen in two of three patients and a disappearance of e antigen in two of two patients. Interferon may be useful in limiting carrier infectivity or eradicating chronic infection.

Original languageEnglish (US)
Pages (from-to)517-522
Number of pages6
JournalNew England Journal of Medicine
Volume295
Issue number10
StatePublished - 1976
Externally publishedYes

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Virus Diseases
Chronic Hepatitis
Hepatitis B virus
Interferon-alpha
Interferons
Hepatitis B Core Antigens
Hepatitis B e Antigens
Chronic Hepatitis B
DNA-Directed DNA Polymerase
Hepatitis B Surface Antigens
Infection
DNA
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Greenberg, H. B., Pollard, R. B., Lutwick, L. I., Gregory, P. B., Robinson, W. S., & Merigan, T. C. (1976). Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis. New England Journal of Medicine, 295(10), 517-522.

Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis. / Greenberg, H. B.; Pollard, Richard B; Lutwick, L. I.; Gregory, P. B.; Robinson, W. S.; Merigan, T. C.

In: New England Journal of Medicine, Vol. 295, No. 10, 1976, p. 517-522.

Research output: Contribution to journalArticle

Greenberg, HB, Pollard, RB, Lutwick, LI, Gregory, PB, Robinson, WS & Merigan, TC 1976, 'Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis', New England Journal of Medicine, vol. 295, no. 10, pp. 517-522.
Greenberg, H. B. ; Pollard, Richard B ; Lutwick, L. I. ; Gregory, P. B. ; Robinson, W. S. ; Merigan, T. C. / Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis. In: New England Journal of Medicine. 1976 ; Vol. 295, No. 10. pp. 517-522.
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