Effect of high dietary glutamic acid on the excretion of 35S-thiamin in kittens

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3 Citations (Scopus)

Abstract

Six kittens individually housed in stainless steel metabolism cages were fed a control diet containing 3% glutamic acid (Glu) for 2 weeks and then subsequently for 12 weeks were fed a 12% Glu diet. All diets contained 4.4 mg thiamin/kg diet. The 12% Glu diet significantly depressed weight gain during the first 6 weeks and food intake during the 3rd and 4th weeks of dietary regimen as compared to the control period. Plasma levels of Glu increased with the duration of the 12% dietary regimen. On days 0, 14, 28 and 42, the kittens were given a 4 g meal containing 10 μCi of 35S-thiamine. Although the mean excretion of isotope in the feces, calculated as a percentage of the ingested dose, was about 25% greater in the first 2 weeks of the 12% Glu dietary regimen than the control period, the difference was not significant. Urinary excretory rate of 35S-thiamin was depressed during the first 4 weeks of the 12% regimen. When exponential relationships were fitted to the excretion data, the coefficients for the first and second 2-week intervals of the 12% Glu dietary regimen were -0.177 and 0-167, respectively, compared to -0.199 and -0.212 obtained for the control period and the third 2-week interval of the high Glu dietary regimen, respectively.

Original languageEnglish (US)
Pages (from-to)1580-1585
Number of pages6
JournalJournal of Nutrition
Volume111
Issue number9
StatePublished - Dec 1 1981

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kittens
Thiamine
thiamin
glutamic acid
Glutamic Acid
excretion
Diet
diet
Stainless Steel
stainless steel
Feces
Isotopes
Weight Gain
Meals
food intake
isotopes
cages
Eating
feces
weight gain

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Effect of high dietary glutamic acid on the excretion of 35S-thiamin in kittens. / Deady, J. E.; Rogers, Quinton; Morris, James.

In: Journal of Nutrition, Vol. 111, No. 9, 01.12.1981, p. 1580-1585.

Research output: Contribution to journalArticle

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abstract = "Six kittens individually housed in stainless steel metabolism cages were fed a control diet containing 3{\%} glutamic acid (Glu) for 2 weeks and then subsequently for 12 weeks were fed a 12{\%} Glu diet. All diets contained 4.4 mg thiamin/kg diet. The 12{\%} Glu diet significantly depressed weight gain during the first 6 weeks and food intake during the 3rd and 4th weeks of dietary regimen as compared to the control period. Plasma levels of Glu increased with the duration of the 12{\%} dietary regimen. On days 0, 14, 28 and 42, the kittens were given a 4 g meal containing 10 μCi of 35S-thiamine. Although the mean excretion of isotope in the feces, calculated as a percentage of the ingested dose, was about 25{\%} greater in the first 2 weeks of the 12{\%} Glu dietary regimen than the control period, the difference was not significant. Urinary excretory rate of 35S-thiamin was depressed during the first 4 weeks of the 12{\%} regimen. When exponential relationships were fitted to the excretion data, the coefficients for the first and second 2-week intervals of the 12{\%} Glu dietary regimen were -0.177 and 0-167, respectively, compared to -0.199 and -0.212 obtained for the control period and the third 2-week interval of the high Glu dietary regimen, respectively.",
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