Abstract
Six kittens individually housed in stainless steel metabolism cages were fed a control diet containing 3% glutamic acid (Glu) for 2 weeks and then subsequently for 12 weeks were fed a 12% Glu diet. All diets contained 4.4 mg thiamin/kg diet. The 12% Glu diet significantly depressed weight gain during the first 6 weeks and food intake during the 3rd and 4th weeks of dietary regimen as compared to the control period. Plasma levels of Glu increased with the duration of the 12% dietary regimen. On days 0, 14, 28 and 42, the kittens were given a 4 g meal containing 10 μCi of 35S-thiamine. Although the mean excretion of isotope in the feces, calculated as a percentage of the ingested dose, was about 25% greater in the first 2 weeks of the 12% Glu dietary regimen than the control period, the difference was not significant. Urinary excretory rate of 35S-thiamin was depressed during the first 4 weeks of the 12% regimen. When exponential relationships were fitted to the excretion data, the coefficients for the first and second 2-week intervals of the 12% Glu dietary regimen were -0.177 and 0-167, respectively, compared to -0.199 and -0.212 obtained for the control period and the third 2-week interval of the high Glu dietary regimen, respectively.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1580-1585 |
| Number of pages | 6 |
| Journal | Journal of Nutrition |
| Volume | 111 |
| Issue number | 9 |
| State | Published - Dec 1 1981 |
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ASJC Scopus subject areas
- Food Science
- Medicine (miscellaneous)
Cite this
Effect of high dietary glutamic acid on the excretion of 35S-thiamin in kittens. / Deady, J. E.; Rogers, Quinton; Morris, James.
In: Journal of Nutrition, Vol. 111, No. 9, 01.12.1981, p. 1580-1585.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of high dietary glutamic acid on the excretion of 35S-thiamin in kittens
AU - Deady, J. E.
AU - Rogers, Quinton
AU - Morris, James
PY - 1981/12/1
Y1 - 1981/12/1
N2 - Six kittens individually housed in stainless steel metabolism cages were fed a control diet containing 3% glutamic acid (Glu) for 2 weeks and then subsequently for 12 weeks were fed a 12% Glu diet. All diets contained 4.4 mg thiamin/kg diet. The 12% Glu diet significantly depressed weight gain during the first 6 weeks and food intake during the 3rd and 4th weeks of dietary regimen as compared to the control period. Plasma levels of Glu increased with the duration of the 12% dietary regimen. On days 0, 14, 28 and 42, the kittens were given a 4 g meal containing 10 μCi of 35S-thiamine. Although the mean excretion of isotope in the feces, calculated as a percentage of the ingested dose, was about 25% greater in the first 2 weeks of the 12% Glu dietary regimen than the control period, the difference was not significant. Urinary excretory rate of 35S-thiamin was depressed during the first 4 weeks of the 12% regimen. When exponential relationships were fitted to the excretion data, the coefficients for the first and second 2-week intervals of the 12% Glu dietary regimen were -0.177 and 0-167, respectively, compared to -0.199 and -0.212 obtained for the control period and the third 2-week interval of the high Glu dietary regimen, respectively.
AB - Six kittens individually housed in stainless steel metabolism cages were fed a control diet containing 3% glutamic acid (Glu) for 2 weeks and then subsequently for 12 weeks were fed a 12% Glu diet. All diets contained 4.4 mg thiamin/kg diet. The 12% Glu diet significantly depressed weight gain during the first 6 weeks and food intake during the 3rd and 4th weeks of dietary regimen as compared to the control period. Plasma levels of Glu increased with the duration of the 12% dietary regimen. On days 0, 14, 28 and 42, the kittens were given a 4 g meal containing 10 μCi of 35S-thiamine. Although the mean excretion of isotope in the feces, calculated as a percentage of the ingested dose, was about 25% greater in the first 2 weeks of the 12% Glu dietary regimen than the control period, the difference was not significant. Urinary excretory rate of 35S-thiamin was depressed during the first 4 weeks of the 12% regimen. When exponential relationships were fitted to the excretion data, the coefficients for the first and second 2-week intervals of the 12% Glu dietary regimen were -0.177 and 0-167, respectively, compared to -0.199 and -0.212 obtained for the control period and the third 2-week interval of the high Glu dietary regimen, respectively.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019773827&partnerID=8YFLogxK
M3 - Article
C2 - 6115896
AN - SCOPUS:0019773827
VL - 111
SP - 1580
EP - 1585
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 9
ER -