Effect of hemodialysis on plasma amino acid concentrations in healthy dogs

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Abstract

Objective - To characterize the effect of maintenance hemodialysis on plasma amino acid concentrations and to quantitate free amino acid losses into the dialysate during hemodialysis in healthy dogs. Animals - 8 healthy adult dogs. Procedure - Five dogs received hemodialysis treatments 3 times per week for 4 weeks. Plasma amino acid concentrations were evaluated once per week for 4 weeks in each of the 5 dogs prior to hemodialysis (time 0), 90 minutes during hemodialysis, and immediately after hemodialysis (180 minutes). Total free amino acid concentrations and plasma amino acid concentrations (time 0, 90 minutes, and 180 minutes) in the dialysate were evaluated in 3 dogs that received 1 hemodialysis treatment. Results - Significant time versus week interactions with any plasma amino acid were not detected; however, significant decreases in all plasma amino acid concentrations measured were detected at the midpoint of dialysis (46 ± 2%) and at the end of each dialysis session (38 ± 2%). Mean (± SEM) total free amino acid loss into the dialysate was 2.7 ± 0.2 g or 0.12 g/kg of body weight. Conclusions and Clinical Relevance - Hemodialysis is associated with significant alterations in plasma amino acid concentrations and loss of free amino acids into the dialysate. Loss of amino acids into the dialysate, coupled with protein calorie malnutrition in uremic patients, may contribute to depletion of amino acid stores.

Original languageEnglish (US)
Pages (from-to)869-873
Number of pages5
JournalAmerican Journal of Veterinary Research
Volume61
Issue number8
StatePublished - Aug 2000

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hemodialysis
Renal Dialysis
Dogs
Amino Acids
amino acids
dogs
Dialysis Solutions
free amino acids
dialysis
protein energy malnutrition
Dialysis
Protein-Energy Malnutrition
body weight
Body Weight
Maintenance

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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title = "Effect of hemodialysis on plasma amino acid concentrations in healthy dogs",
abstract = "Objective - To characterize the effect of maintenance hemodialysis on plasma amino acid concentrations and to quantitate free amino acid losses into the dialysate during hemodialysis in healthy dogs. Animals - 8 healthy adult dogs. Procedure - Five dogs received hemodialysis treatments 3 times per week for 4 weeks. Plasma amino acid concentrations were evaluated once per week for 4 weeks in each of the 5 dogs prior to hemodialysis (time 0), 90 minutes during hemodialysis, and immediately after hemodialysis (180 minutes). Total free amino acid concentrations and plasma amino acid concentrations (time 0, 90 minutes, and 180 minutes) in the dialysate were evaluated in 3 dogs that received 1 hemodialysis treatment. Results - Significant time versus week interactions with any plasma amino acid were not detected; however, significant decreases in all plasma amino acid concentrations measured were detected at the midpoint of dialysis (46 ± 2{\%}) and at the end of each dialysis session (38 ± 2{\%}). Mean (± SEM) total free amino acid loss into the dialysate was 2.7 ± 0.2 g or 0.12 g/kg of body weight. Conclusions and Clinical Relevance - Hemodialysis is associated with significant alterations in plasma amino acid concentrations and loss of free amino acids into the dialysate. Loss of amino acids into the dialysate, coupled with protein calorie malnutrition in uremic patients, may contribute to depletion of amino acid stores.",
author = "Elliott, {Denise A.} and Marks, {Stanley L} and Cowgill, {Larry D} and Kass, {Philip H} and Quinton Rogers",
year = "2000",
month = "8",
language = "English (US)",
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pages = "869--873",
journal = "American Journal of Veterinary Research",
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T1 - Effect of hemodialysis on plasma amino acid concentrations in healthy dogs

AU - Elliott, Denise A.

AU - Marks, Stanley L

AU - Cowgill, Larry D

AU - Kass, Philip H

AU - Rogers, Quinton

PY - 2000/8

Y1 - 2000/8

N2 - Objective - To characterize the effect of maintenance hemodialysis on plasma amino acid concentrations and to quantitate free amino acid losses into the dialysate during hemodialysis in healthy dogs. Animals - 8 healthy adult dogs. Procedure - Five dogs received hemodialysis treatments 3 times per week for 4 weeks. Plasma amino acid concentrations were evaluated once per week for 4 weeks in each of the 5 dogs prior to hemodialysis (time 0), 90 minutes during hemodialysis, and immediately after hemodialysis (180 minutes). Total free amino acid concentrations and plasma amino acid concentrations (time 0, 90 minutes, and 180 minutes) in the dialysate were evaluated in 3 dogs that received 1 hemodialysis treatment. Results - Significant time versus week interactions with any plasma amino acid were not detected; however, significant decreases in all plasma amino acid concentrations measured were detected at the midpoint of dialysis (46 ± 2%) and at the end of each dialysis session (38 ± 2%). Mean (± SEM) total free amino acid loss into the dialysate was 2.7 ± 0.2 g or 0.12 g/kg of body weight. Conclusions and Clinical Relevance - Hemodialysis is associated with significant alterations in plasma amino acid concentrations and loss of free amino acids into the dialysate. Loss of amino acids into the dialysate, coupled with protein calorie malnutrition in uremic patients, may contribute to depletion of amino acid stores.

AB - Objective - To characterize the effect of maintenance hemodialysis on plasma amino acid concentrations and to quantitate free amino acid losses into the dialysate during hemodialysis in healthy dogs. Animals - 8 healthy adult dogs. Procedure - Five dogs received hemodialysis treatments 3 times per week for 4 weeks. Plasma amino acid concentrations were evaluated once per week for 4 weeks in each of the 5 dogs prior to hemodialysis (time 0), 90 minutes during hemodialysis, and immediately after hemodialysis (180 minutes). Total free amino acid concentrations and plasma amino acid concentrations (time 0, 90 minutes, and 180 minutes) in the dialysate were evaluated in 3 dogs that received 1 hemodialysis treatment. Results - Significant time versus week interactions with any plasma amino acid were not detected; however, significant decreases in all plasma amino acid concentrations measured were detected at the midpoint of dialysis (46 ± 2%) and at the end of each dialysis session (38 ± 2%). Mean (± SEM) total free amino acid loss into the dialysate was 2.7 ± 0.2 g or 0.12 g/kg of body weight. Conclusions and Clinical Relevance - Hemodialysis is associated with significant alterations in plasma amino acid concentrations and loss of free amino acids into the dialysate. Loss of amino acids into the dialysate, coupled with protein calorie malnutrition in uremic patients, may contribute to depletion of amino acid stores.

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